Protein detail
AFAM
Afamin (Alpha-albumin) (Alpha-Alb)
Entry name AFAM | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Plasma proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Afamin (Alpha-albumin) (Alpha-Alb)
Protein Class (2)
Plasma proteinsPredicted secreted proteins
Protein Function
Predicted secreted proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
ALB2ALBA
Gene Description
Afamin
Chromosome
4
Position
73481745-73504001
Supporting publications (n)
3
EVMP confidence score
0.38
Fluorescence & Localization2
Cell SpecificProstatic glandular cellsBlood Cell Specificplasmacytoid DC
Function & Pathway4
Protein Function
Predicted secreted proteins
Cellular Component (5)
Molecular Function (2)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence11
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | Yes | No | No |
| ecm | ecm | OmniPath | Yes | No | Yes | No | No |
| extracellular | extracellular | LOCATE | No | No | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | HPA_secretome | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 37427430 |
Sequence, Structure & Domains12
Sequences
Length
599
Mass
69,069
Sequence
MKLLKLTGFIFFLFFLTESLTLPTQPRDIENFNSTQKFIEDNIEYITIIAFAQYVQEATFEEMEKLVKDMVEYKDRCMADKTLPECSKLPNNVLQEKICAMEGLPQKHNFSHCCSKVDAQRRLCFFYNKKSDVGFLPPFPTLDPEEKCQAYESNRESLLNHFLYEVARRNPFVFAPTLLTVAVHFEEVAKSCCEEQNKVNCLQTRAIPVTQYLKAFSSYQKHVCGALLKFGTKVVHFIYIAILSQKFPKIEFKELISLVEDVSSNYDGCCEGDVVQCIRDTSKVMNHICSKQDSISSKIKECCEKKIPERGQCIINSNKDDRPKDLSLREGKFTDSENVCQERDADPDTFFAKFTFEYSRRHPDLSIPELLRIVQIYKDLLRNCCNTENPPGCYRYAEDKFNETTEKSLKMVQQECKHFQNLGKDGLKYHYLIRLTKIAPQLSTEELVSLGEKMVTAFTTCCTLSEEFACVDNLADLVFGELCGVNENRTINPAVDHCCKTNFAFRRPCFESLKADKTYVPPPFSQDLFTFHADMCQSQNEELQRKTDRFLVNLVKLKHELTDEELQSLFTNFANVVDKCCKAESPEVCFNEESPKIGN
3D Structural Models
Turn
55..57; 293..295; 300..304; 331..335; 558..560
Helix
34..41; 43..54; 60..79; 84..87; 90..99; 104..107; 111..114; 118..127; 144..153; 155..169; 175..192; 198..230; 232..235; 237..246; 252..271; 274..289; 309..316; 339..345; 347..360; 367..384; 390..394; 397..438; 444..461; 467..483; 493..500; 506..511; 526..529; 533..535; 542..557; 563..581; 586..593
Beta Strand
195..197; 485..487; 583..585
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Domain (CC)
The second albumin domain forms a deep binding pocket that contains palmitoleic acid (in vitro) (PubMed:29153507). Palmitoleic acid is most likely not the physiological ligand. Instead, this pocket may accomodate the covalently bound lipid moiety of Wnt family members (Probable).
Domain (FT)
22..210; Albumin 1; 211..403; Albumin 2; 404..599; Albumin 3
Region
215..319; Binding pocket for hydrophobic ligands
Protein Families
ALB/AFP/VDB family
Sequence Similarities
Belongs to the ALB/AFP/VDB family.
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 38037300 | Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles. | No abstract available |
| 40596376 | Proteomic profiling of plasma extracellular vesicles identifies signatures of innate immunity, coagulation, and endothelial activation in septic patients. | No abstract available |
| 40689422 | Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles. | No abstract available |