Protein detail
MK09
Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)
Protein symbol MK09 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification EnzymesPredicted intracellular proteinsRAS pathway related proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)
Protein Class
EnzymesPredicted intracellular proteinsRAS pathway related proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- RAS pathway related proteins
- Enzymes
- Kinases:CMGC Ser/Thr protein kinases
Ensembl
Entrez Gene Symbol
Gene Synonym
JNK2p54aPRKM9SAPK
Gene Description
Mitogen-activated protein kinase 9
Chromosome
5
Position
180233143-180292099
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificCone photoreceptor cells
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- RAS pathway related proteins
- Enzymes
- Kinases:CMGC Ser/Thr protein kinases
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa01522 Endocrine resistance
- KEGG:hsa04010 MAPK signaling pathway
- KEGG:hsa04012 ErbB signaling pathway
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04068 FoxO signaling pathway
- KEGG:hsa04071 Sphingolipid signaling pathway
- KEGG:hsa04137 Mitophagy - animal
- KEGG:hsa04140 Autophagy - animal
- KEGG:hsa04141 Protein processing in endoplasmic reticulum
- KEGG:hsa04210 Apoptosis
- KEGG:hsa04215 Apoptosis - multiple species
- KEGG:hsa04217 Necroptosis
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04530 Tight junction
- KEGG:hsa04620 Toll-like receptor signaling pathway
- KEGG:hsa04621 NOD-like receptor signaling pathway
- KEGG:hsa04622 RIG-I-like receptor signaling pathway
- KEGG:hsa04625 C-type lectin receptor signaling pathway
- KEGG:hsa04657 IL-17 signaling pathway
- KEGG:hsa04658 Th1 and Th2 cell differentiation
- KEGG:hsa04659 Th17 cell differentiation
- KEGG:hsa04660 T cell receptor signaling pathway
- KEGG:hsa04664 Fc epsilon RI signaling pathway
- KEGG:hsa04668 TNF signaling pathway
- KEGG:hsa04722 Neurotrophin signaling pathway
- KEGG:hsa04723 Retrograde endocannabinoid signaling
- KEGG:hsa04728 Dopaminergic synapse
- KEGG:hsa04750 Inflammatory mediator regulation of TRP channels
- KEGG:hsa04910 Insulin signaling pathway
- KEGG:hsa04912 GnRH signaling pathway
- KEGG:hsa04914 Progesterone-mediated oocyte maturation
- KEGG:hsa04917 Prolactin signaling pathway
- KEGG:hsa04920 Adipocytokine signaling pathway
- KEGG:hsa04926 Relaxin signaling pathway
- KEGG:hsa04930 Type II diabetes mellitus
- KEGG:hsa04931 Insulin resistance
- KEGG:hsa04932 Non-alcoholic fatty liver disease
- KEGG:hsa04933 AGE-RAGE signaling pathway in diabetic complications
- KEGG:hsa04935 Growth hormone synthesis, secretion and action
- KEGG:hsa04936 Alcoholic liver disease
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05012 Parkinson disease
- KEGG:hsa05016 Huntington disease
- KEGG:hsa05017 Spinocerebellar ataxia
- KEGG:hsa05020 Prion disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05120 Epithelial cell signaling in Helicobacter pylori infection
- KEGG:hsa05130 Pathogenic Escherichia coli infection
- KEGG:hsa05131 Shigellosis
- KEGG:hsa05132 Salmonella infection
- KEGG:hsa05133 Pertussis
- KEGG:hsa05135 Yersinia infection
- KEGG:hsa05142 Chagas disease
- KEGG:hsa05145 Toxoplasmosis
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05161 Hepatitis B
- KEGG:hsa05162 Measles
- KEGG:hsa05166 Human T-cell leukemia virus 1 infection
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
- KEGG:hsa05169 Epstein-Barr virus infection
- KEGG:hsa05170 Human immunodeficiency virus 1 infection
- KEGG:hsa05171 Coronavirus disease
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05208 Chemical carcinogenesis - reactive oxygen species
- KEGG:hsa05210 Colorectal cancer
- KEGG:hsa05212 Pancreatic cancer
- KEGG:hsa05231 Choline metabolism in cancer
- KEGG:hsa05415 Diabetic cardiomyopathy
- KEGG:hsa05417 Lipid and atherosclerosis
- KEGG:hsa05418 Fluid shear stress and atherosclerosis
Reactome
- R-hsa-450341 activation of the ap 1 family of transcription factors
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-2559583 cellular senescence
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-2871796 fceri mediated mapk activation
- R-hsa-2454202 fc epsilon receptor fceri signaling
- R-hsa-168249 innate immune system
- R-hsa-448424 interleukin 17 signaling
- R-hsa-450321 jnk c jun kinases phosphorylation and activation mediated by activated human tak1
- R-hsa-450282 mapk targets nuclear events mediated by map kinases
- R-hsa-166166 myd88 independent tlr4 cascade
- R-hsa-2559580 oxidative stress induced senescence
- R-hsa-9700206 signaling by alk in cancer
- R-hsa-449147 signaling by interleukins
- R-hsa-168138 toll like receptor 9 tlr9 cascade
- R-hsa-168898 toll like receptor cascades
- R-hsa-168179 toll like receptor tlr1 tlr2 cascade
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
30 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MAPK9 | CHKA | P35790 | Y | 185 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25404879 |
| MAPK9 | CHKA | P35790 | T | 183 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25404879 |
| MAPK9 | LIPG | Q9Y5X9 | T | 183 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:29234693 |
| MAPK9 | TOR1A | O14656 | T | 183 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:29234691 |
| MAPK9 | JUN | P05412 | T | 183 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:26569339 |
| MAPK9 | CXXC1 | Q9P0U4 | T | 183 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:29147012 |
| MAPK9 | MAP3K4 | Q9Y6R4 | T | 183 | phosphorylation | KEA | KEA:11062067 |
| MAPK9 | MAP3K4 | Q9Y6R4 | Y | 185 | phosphorylation | KEA | KEA:11062067 |
| MAPK9 | PRKCA | P17252 | T | 404 | phosphorylation | KEA | KEA:17570479 |
| MAPK9 | PRKCB | P05771 | S | 129 | phosphorylation | KEA | KEA:16061178 |
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Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
55 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MK09 | P45984 | BAZ1B | Q9UIG0 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper | ProtMapper:19776015SIGNOR:19776015 |
| MK09 | P45984 | 1433S | P31947 | Yes | No | Yes | iPTMnetSIGNORProtMapperACSNSIGNOR_ProtMapper | SIGNOR:15071501ProtMapper:15071501ACSN:15071501 |
| MK09 | P45984 | B2L11 | O43521 | Yes | Yes | Yes | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEANCI-PID_ProtMapperHPRDWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperACSNHPRD-phos | KEA:14555991phosphoELM:12591950ACSN:12591950HPRD-phos:18691976KEA:15486195SIGNOR:12818176KEA:12818176ProtMapper:15470142KEA:12591950HPRD-phos:12818176ProtMapper:12818176ProtMapper:18174237ProtMapper:18691976SIGNOR:18174237HPRD:12818176 |
| MK09 | P45984 | IRS1 | P35568 | Yes | No | Yes | WangSparser_ProtMapperiPTMnetSIGNORPhosphoPointProtMapperHPRDRLIMS-P_ProtMapperSIGNOR_ProtMapper | ProtMapper:14579029SIGNOR:14579029ProtMapper:9335553ProtMapper:11160134ProtMapper:23050932SIGNOR:9335553HPRD:12417588 |
| MK09 | P45984 | ELK3 | P41970 | Yes | No | Yes | phosphoELM_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEA | KEA:11042694HPRD:11042694SIGNOR:11042694ProtMapper:11042694 |
| RAC1 | P63000 | MK09 | P45984 | Yes | Yes | No | KEGG-MEDICUSNCI-PID_ProtMapperSIGNORProtMapperWang | ProtMapper:18426980ProtMapper:18423204SIGNOR:18423204 |
| MK09 | P45984 | EGLN2 | Q96KS0 | Yes | Yes | No | REACH_ProtMapperSIGNORProtMapper | SIGNOR:27263528ProtMapper:27263528 |
| MK09 | P45984 | BID | P55957 | Yes | Yes | No | iPTMnetSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_ProtMapper | SIGNOR:25077544ProtMapper:25077544 |
| MK09 | P45984 | SRC | P12931 | Yes | Yes | No | SIGNOR | SIGNOR:25377781 |
| MK09 | P45984 | AT2A2 | P16615 | Yes | Yes | No | SIGNOR | SIGNOR:33334123 |
Protein Complex Composition
13 records.
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30550287 |
Sequence, Structure & Domains
Sequences
Length
424
Mass
48,139
Sequence
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=Alpha-2; IsoId=P45984-1; Sequence=Displayed; Name=Alpha-1; IsoId=P45984-2; Sequence=VSP_004835; Name=Beta-1; IsoId=P45984-3; Sequence=VSP_004834, VSP_004835; Name=Beta-2; IsoId=P45984-4; Sequence=VSP_004834; Name=5; IsoId=P45984-5; Sequence=VSP_041908, VSP_041909
Alternative Sequence
216..230; GELVKGCVIFQGTDH -> AEMVLHKVLFPGRDY (in isoform Beta-1 and isoform Beta-2); 230..242; HIDQWNKVIEQLG -> RILPRDLGPAMLS (in isoform 5); 243..424; Missing (in isoform 5); 378..424; DAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR -> AQMQQ (in isoform Alpha-1 and isoform Beta-1)
3D Structural Models
Turn
6..8; 46..49; 60..62; 98..100; 176..178; 306..308
Helix
64..79; 115..118; 119..121; 125..144; 154..156; 189..191; 194..197; 206..220; 230..241; 246..250; 254..262; 271..274; 277..279; 285..301; 312..316; 319..322; 327..330; 349..361
Beta Strand
11..23; 26..35; 38..45; 50..59; 88..92; 103..109; 112..114; 157..159; 165..167; 179..181; 342..344
3D Structure
X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
388..417; Low complexity
Motif
183..185; TXY
Domain (CC)
The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Domain (FT)
26..321; Protein kinase
Region
368..424; Disordered
Protein Families
- Protein kinase superfamily
- CMGC Ser/Thr protein kinase family
- MAP kinase subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Clinical Relevance
Drugs
BENTAMAPIMODGO-6976SB203580GW441756XSB220025CC-401SP-600125CP-547632PD-0166285CARDAMOMINNVP-TAE684PP2PALBOCICLIBPAZOPANIBPF-562271OXIDOPAMINETAMATINIBDORAMAPIMODSORAFENIBSB202190JNK INHIBITOR VIIIR-1487RG-1530CAMPTOTHECINCHEMBL:CHEMBL1997335LINIFANIBTAK-715BRIMAPITIDEGEFITINIBCYC-116TANZISERTIBCENISERTIB
Interaction Protein
ENSG00000065559ENSG00000072201ENSG00000075702ENSG00000107643ENSG00000111266ENSG00000115966ENSG00000120875ENSG00000137486ENSG00000139517ENSG00000143507ENSG00000146648ENSG00000189325ENSG00000270885
Interaction Count
13
Interaction Dataset
intact_biogrid_opencellintact_biogrid