Protein detail
CRK
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Entry name CRK | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
CRK proto-oncogene, adaptor protein
Chromosome
17
Position
1420689-1463162
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0001784 phosphotyrosine residue binding
- GO:0005159 insulin-like growth factor receptor binding
- GO:0005515 protein binding
- GO:0008092 cytoskeletal protein binding
- GO:0017124 SH3 domain binding
- GO:0019900 kinase binding
- GO:0030159 signaling receptor complex adaptor activity
- GO:0030971 receptor tyrosine kinase binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0035591 signaling adaptor activity
- GO:0042169 SH2 domain binding
- GO:0045309 protein phosphorylated amino acid binding
- GO:0046875 ephrin receptor binding
- GO:0097110 scaffold protein binding
- GO:1990782 protein tyrosine kinase binding
Biological Process
KEGG
- hsa04010 MAPK signaling pathway
- KEGG:hsa04012 ErbB signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04148 Efferocytosis
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa04722 Neurotrophin signaling pathway
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04910 Insulin signaling pathway
- KEGG:hsa04935 Growth hormone synthesis, secretion and action
- KEGG:hsa05100 Bacterial invasion of epithelial cells
- KEGG:hsa05131 Shigellosis
- KEGG:hsa05135 Yersinia infection
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05170 Human immunodeficiency virus 1 infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05206 MicroRNAs in cancer
- KEGG:hsa05211 Renal cell carcinoma
- KEGG:hsa05220 Chronic myeloid leukemia
Reactome
- R-hsa-170984 arms mediated activation
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-186763 downstream signal transduction
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-109582 hemostasis
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-354192 integrin signaling
- R-hsa-512988 interleukin 3 interleukin 5 and gm csf signaling
- R-hsa-9658195 leishmania infection
- R-hsa-8875555 met activates rap1 and rac1
- R-hsa-8875878 met promotes cell motility
- R-hsa-8875656 met receptor recycling
- R-hsa-372708 p130cas linkage to mapk signaling for integrins
- R-hsa-9664407 parasite infection
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-76009 platelet aggregation plug formation
- R-hsa-169893 prolonged erk activation events
- R-hsa-8849471 ptk6 regulates rho gtpases ras gtpase and map kinases
- R-hsa-912631 regulation of signaling by cbl
- R-hsa-449147 signaling by interleukins
- R-hsa-6806834 signaling by met
- R-hsa-166520 signaling by ntrks
- R-hsa-186797 signaling by pdgf
- R-hsa-8848021 signaling by ptk6
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-194138 signaling by vegf
- R-hsa-187687 signalling to erks
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
36 records.
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Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| adhesion_cytoskeleton_adaptor | intracellular_intercellular_related | Adhesome | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
19 records.
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Protein Complex Composition
14 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CRKII-C3G complex | CRKRAPGEF1 | P46108Q13905 | 1:1 | CompleatCORUM | CORUM:5444Compleat:HC3214 | 9564038 |
| Cbl-Crkl-Rapgef1 complex | CBLCRKCRKLRAPGEF1 | P22681P46108P46109Q13905 | 1:1:1:1 | Compleat | Compleat:HC3199 | 10608804 |
| ELMO1-DOCK1-CRKII complex | CRKDOCK1ELMO1 | P46108Q14185Q92556 | 1:1:1 | CompleatCORUM | CORUM:5343Compleat:HC1884 | 16025104 |
| HT_DM_Cluster496 | CRKCRKLSEC14L4TTPA | P46108P46109P49638Q9UDX3 | 1:1:1:1 | Compleat | Compleat:HC3095 | 22036573 |
| AHSA1CRKGALE | O95433P46108Q14376 | 0:0:0 | hu.MAP2 | |||
| ABL1CRKSHC1SP1UBC | P00519P08047P0CG48P29353P46108 | 1:1:1:1:1 | CompleatCFinder | Compleat:HC6722 | ||
| CBLCRKCRKL | P22681P46108P46109 | 0:0:0 | KEGG-MEDICUS | |||
| CRKPPIA | P46108P62937 | 1:1 | PDB | PDB:2ms4 | ||
| CRKFKBP4 | P46108Q02790 | 0:0 | hu.MAP2 | |||
| CRKDOCK1 | P46108Q14185 | 0:0 | hu.MAP |
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Sequence, Structure & Domains
Sequences
Length
304
Mass
33,831
Sequence
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=Crk-II; IsoId=P46108-1; Sequence=Displayed; Name=Crk-I; IsoId=P46108-2; Sequence=VSP_041153, VSP_041154
Alternative Sequence
204; N -> R (in isoform Crk-I); 205..304; Missing (in isoform Crk-I)
3D Structural Models
Turn
78..80
Helix
20..27; 97..106; 126..128; 184..186; 288..290
Beta Strand
7..13; 14..16; 30..33; 34..39; 41..43; 46..52; 54..56; 57..63; 66..69; 70..77; 87..89; 92..96; 109..112; 116..118; 120..123; 135..141; 146..150; 158..163; 165..173; 179..183; 187..190; 208..210; 224..227; 229..231; 239..242; 253..255; 260..269; 273..279; 282..287
3D Structure
NMR spectroscopy (8); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
67..82; Pro residues
Domain (CC)
The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation.; DOMAIN: The SH2 domain mediates interaction with tyrosine phosphorylated proteins. Mediates interaction with SHB.
Domain (FT)
13..118; SH2; 132..192; SH3 1; 235..296; SH3 2
Region
61..85; Disordered; 201..229; Disordered
Protein Families
CRK family
Sequence Similarities
Belongs to the CRK family.
Clinical Relevance
Disease Involvement
Proto-oncogene
Interaction Protein
ENSG00000012983ENSG00000050820ENSG00000088179ENSG00000088280ENSG00000097007ENSG00000100485ENSG00000100519ENSG00000100599ENSG00000102048ENSG00000104814ENSG00000107263ENSG00000107643ENSG00000110395ENSG00000114423ENSG00000115904ENSG00000117461ENSG00000121570ENSG00000123154ENSG00000124788ENSG00000134909ENSG00000141441ENSG00000143322ENSG00000145390ENSG00000146648ENSG00000147459ENSG00000150760ENSG00000153317ENSG00000157404ENSG00000166387ENSG00000169398ENSG00000169679
Interaction Count
31
Interaction Dataset
intact_biogrid