Protein detail
SO1A2
Solute carrier organic anion transporter family member 1A2 (OATP1A2) (OATP-A) (Organic anion-transporting polypeptide 1) (OATP-1) (Sodium-independent organic anion transporter) (Solute carrier family 21 member 3)
Entry name SO1A2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 12 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Solute carrier organic anion transporter family member 1A2 (OATP1A2) (OATP-A) (Organic anion-transporting polypeptide 1) (OATP-1) (Sodium-independent organic anion transporter) (Solute carrier family 21 member 3)
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Transmembrane
21..40; Helical; Name=1; 60..80; Helical; Name=2; 87..111; Helical; Name=3; 156..184; Helical; Name=4; 204..224; Helical; Name=5; 243..267; Helical; Name=6; 312..333; Helical; Name=7; 354..377; Helical; Name=8; 382..405; Helical; Name=9; 514..536; Helical; Name=10; 546..571; Helical; Name=11; 606..623; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization2
Cell SpecificmonocytesSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway7
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Cellular Component (4)
Molecular Function (5)
Biological Process (3)
Reactome (10)
- R-hsa-194068 bile acid and bile salt metabolism
- R-hsa-9793528 ciprofloxacin adme
- R-hsa-9748784 drug adme
- R-hsa-556833 metabolism of lipids
- R-hsa-8957322 metabolism of steroids
- R-hsa-879518 organic anion transport by slco transporters
- R-hsa-159418 recycling of bile acids and salts
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9955298 slc mediated transport of organic anions
- R-hsa-382551 transport of small molecules
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence21
Ligand-Receptor Signaling (20)
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| mfs | transporter | Surfaceome | No | Yes | No | No | No |
| slco | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
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Sequence, Structure & Domains9
Sequences
Length
670
Mass
74,145
Sequence
MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRKCHLPGENASSGTELIETKVKGKENECKDIYQKSTVLKDDELKTKL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=OATP1a; IsoId=P46721-1; Sequence=Displayed; Name=OATP1b; IsoId=P46721-2; Sequence=VSP_006130, VSP_006131, VSP_006132
Alternative Sequence
1..19; MGETEKRIETHRIRCLSKL -> MFLTKNCKQEQERVESA (in isoform OATP1b); 559..581; AGIPAPIYFGALMDSTCLHWGTL -> GKNSYFFPHPIRTILLLLFFITL (in isoform OATP1b); 582..670; Missing (in isoform OATP1b)
Domain & Motif Annotations
Domain (CC)
A conserved histidine residue in the third TMD (His-107) may play an essential role in the pH sensitivity of SLCO1A2/OATP1A2-mediated substrate transport.
Domain (FT)
433..488; Kazal-like
Protein Families
Organo anion transporter (TC 2.A.60) family
Sequence Similarities
Belongs to the organo anion transporter (TC 2.A.60) family.
Clinical Relevance1
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |