Protein detail
IQGA1
Ras GTPase-activating-like protein IQGAP1 (p195)
Entry name IQGA1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Ras GTPase-activating-like protein IQGAP1 (p195)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
HUMORFA01KIAA0051p195SAR1
Gene Description
IQ motif containing GTPase activating protein 1
Chromosome
15
Position
90388242-90502239
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (25)
- GO:0001726 ruffle
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005874 microtubule
- GO:0005884 actin filament
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0005938 cell cortex
- GO:0009898 cytoplasmic side of plasma membrane
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Molecular Function (16)
- GO:0005078 MAP-kinase scaffold activity
- GO:0005095 GTPase inhibitor activity
- GO:0005096 GTPase activator activity
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0005516 calmodulin binding
- GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
- GO:0019901 protein kinase binding
- GO:0019903 protein phosphatase binding
- GO:0019904 protein domain specific binding
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KEGG (4)
Reactome (26)
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-1500931 cell cell communication
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-381676 glucagon like peptide 1 glp1 regulates insulin secretion
- R-hsa-168249 innate immune system
- R-hsa-163685 integration of energy metabolism
- R-hsa-5674135 map2k and mapk activation
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-373753 nephrin family interactions
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Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence29
Enzyme-Mediated Modification (8)
8 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| IQGAP1 | PRKCE | Q02156 | S | 1,443 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15355962SIGNOR:21349850phosphoELM:15355962ProtMapper:15355962ProtMapper:19295129ProtMapper:21349850SIGNOR:15355962SIGNOR:15695813ProtMapper:20495773ProtMapper:15695813 |
| IQGAP1 | PRKCA | P17252 | S | 1,443 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:21349850ProtMapper:25618329ProtMapper:15355962ProtMapper:21349850ProtMapper:25733387SIGNOR:15355962SIGNOR:15695813ProtMapper:15695813 |
| IQGAP1 | SRC | P12931 | Y | 1,510 | phosphorylation | PhosphoSite | |
| IQGAP1 | MET | P08581 | Y | 1,510 | phosphorylation | PhosphoSite | |
| IQGAP1 | MAP4K3 | Q8IVH8 | S | 480 | phosphorylation | PhosphoSite | |
| IQGAP1 | LGR5 | O75473 | S | 1,443 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:28739799 |
| IQGAP1 | EGFR | P00533 | S | 1,443 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:22182509 |
| IQGAP1 | MAPK10 | P53779 | S | 330 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (8)
8 records.
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CDC42CLIP1IQGAP1RAC1STAU1UBC | O95793P0CG48P30622P46940P60953P63000 | 1:1:1:1:1:1 | CompleatCFinder | Compleat:HC4052 | ||
| CDC5LIQGAP1SNW1TSG101UBC | P0CG48P46940Q13573Q99459Q99816 | 1:1:1:1:1 | CompleatCFinder | Compleat:HC4321 | ||
| ACTC1ESYT1IQGAP1MYH10 | P35580P46940P68032Q9BSJ8 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_238 | ||
| IQGAP1 | P46940 | 4 | PDB | PDB:3i6xPDB:5l0o |
Sequence, Structure & Domains11
Sequences
Length
1,657
Mass
189,252
Sequence
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK
3D Structural Models
Turn
87..89; 96..99; 172..174; 206..208; 1010..1013; 1203..1207; 1285..1287; 1636..1638
Helix
31..58; 65..67; 70..72; 76..85; 92..94; 101..105; 110..112; 113..125; 130..132; 136..140; 145..161; 179..190; 199..201; 962..981; 984..991; 1000..1009; 1016..1037; 1043..1046; 1050..1058; 1062..1081; 1091..1106; 1118..1121; 1125..1150; 1151..1155; 1158..1174; 1180..1191; 1192..1196; 1197..1201; 1219..1236; 1246..1248; 1249..1270; 1275..1278; 1299..1311; 1313..1316; 1323..1331; 1565..1571; 1583..1587; 1619..1628; 1643..1652
Beta Strand
1039..1042; 1282..1284; 1290..1292; 1561..1564; 1572..1577; 1589..1593; 1596..1599; 1601..1608; 1615..1617; 1632..1635; 1639..1642
3D Structure
NMR spectroscopy (2); X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
1417..1448; Basic and acidic residues
Domain (CC)
Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of nucleotide-free CDC42 and promotes binding of GTP-bound CDC42. Phosphorylation of Ser-1443 prevents interaction between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free CDC42 on both C1 and C2..
Domain (FT)
44..159; Calponin-homology (CH); 679..712; WW; 745..774; IQ 1; 775..804; IQ 2; 805..834; IQ 3; 835..864; IQ 4; 1020..1269; Ras-GAP
Region
956..1274; C1; 1276..1657; C2; 1410..1448; Disordered
Clinical Relevance4
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 39363010 | Proteomic analysis of plasma-derived extracellular vesicles: pre- and postprandial comparisons. | No abstract available |