Protein detail
IQGA1
Ras GTPase-activating-like protein IQGAP1 (p195)
Protein symbol IQGA1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ras GTPase-activating-like protein IQGAP1 (p195)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
HUMORFA01KIAA0051p195SAR1
Gene Description
IQ motif containing GTPase activating protein 1
Chromosome
15
Position
90388242-90502239
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
- GO:0001726 ruffle
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005874 microtubule
- GO:0005884 actin filament
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0005938 cell cortex
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0015629 actin cytoskeleton
- GO:0015630 microtubule cytoskeleton
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0016328 lateral plasma membrane
- GO:0030424 axon
- GO:0030426 growth cone
- GO:0030496 midbody
- GO:0030667 secretory granule membrane
- GO:0030864 cortical actin cytoskeleton
- GO:0036057 slit diaphragm
- GO:0036464 cytoplasmic ribonucleoprotein granule
- GO:0043005 neuron projection
- GO:0070062 extracellular exosome
- GO:1990904 ribonucleoprotein complex
Molecular Function
- GO:0005078 MAP-kinase scaffold activity
- GO:0005095 GTPase inhibitor activity
- GO:0005096 GTPase activator activity
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0005516 calmodulin binding
- GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
- GO:0019901 protein kinase binding
- GO:0019903 protein phosphatase binding
- GO:0019904 protein domain specific binding
- GO:0031267 small GTPase binding
- GO:0043539 protein serine/threonine kinase activator activity
- GO:0044548 S100 protein binding
- GO:0045296 cadherin binding
- GO:0051015 actin filament binding
- GO:0060090 molecular adaptor activity
KEGG
Reactome
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-1500931 cell cell communication
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-381676 glucagon like peptide 1 glp1 regulates insulin secretion
- R-hsa-168249 innate immune system
- R-hsa-163685 integration of energy metabolism
- R-hsa-5674135 map2k and mapk activation
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-373753 nephrin family interactions
- R-hsa-6798695 neutrophil degranulation
- R-hsa-6802957 oncogenic mapk signaling
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-9013404 rac2 gtpase cycle
- R-hsa-422356 regulation of insulin secretion
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9013406 rhoq gtpase cycle
- R-hsa-9013420 rhou gtpase cycle
- R-hsa-9013424 rhov gtpase cycle
- R-hsa-5626467 rho gtpases activate iqgaps
- R-hsa-9012999 rho gtpase cycle
- R-hsa-195258 rho gtpase effectors
- R-hsa-6802952 signaling by braf and raf1 fusions
- R-hsa-6802946 signaling by moderate kinase activity braf mutants
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
8 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| IQGAP1 | PRKCE | Q02156 | S | 1,443 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15355962SIGNOR:21349850phosphoELM:15355962ProtMapper:15355962ProtMapper:19295129ProtMapper:21349850SIGNOR:15355962SIGNOR:15695813ProtMapper:20495773ProtMapper:15695813 |
| IQGAP1 | PRKCA | P17252 | S | 1,443 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:21349850ProtMapper:25618329ProtMapper:15355962ProtMapper:21349850ProtMapper:25733387SIGNOR:15355962SIGNOR:15695813ProtMapper:15695813 |
| IQGAP1 | SRC | P12931 | Y | 1,510 | phosphorylation | PhosphoSite | |
| IQGAP1 | MET | P08581 | Y | 1,510 | phosphorylation | PhosphoSite | |
| IQGAP1 | MAP4K3 | Q8IVH8 | S | 480 | phosphorylation | PhosphoSite | |
| IQGAP1 | LGR5 | O75473 | S | 1,443 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:28739799 |
| IQGAP1 | EGFR | P00533 | S | 1,443 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:22182509 |
| IQGAP1 | MAPK10 | P53779 | S | 330 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
8 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CDC42CLIP1IQGAP1RAC1STAU1UBC | O95793P0CG48P30622P46940P60953P63000 | 1:1:1:1:1:1 | CompleatCFinder | Compleat:HC4052 | ||
| CDC5LIQGAP1SNW1TSG101UBC | P0CG48P46940Q13573Q99459Q99816 | 1:1:1:1:1 | CompleatCFinder | Compleat:HC4321 | ||
| ACTC1ESYT1IQGAP1MYH10 | P35580P46940P68032Q9BSJ8 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_238 | ||
| IQGAP1 | P46940 | 4 | PDB | PDB:3i6xPDB:5l0o |
Sequence, Structure & Domains
Sequences
Length
1,657
Mass
189,252
Sequence
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK
3D Structural Models
Turn
87..89; 96..99; 172..174; 206..208; 1010..1013; 1203..1207; 1285..1287; 1636..1638
Helix
31..58; 65..67; 70..72; 76..85; 92..94; 101..105; 110..112; 113..125; 130..132; 136..140; 145..161; 179..190; 199..201; 962..981; 984..991; 1000..1009; 1016..1037; 1043..1046; 1050..1058; 1062..1081; 1091..1106; 1118..1121; 1125..1150; 1151..1155; 1158..1174; 1180..1191; 1192..1196; 1197..1201; 1219..1236; 1246..1248; 1249..1270; 1275..1278; 1299..1311; 1313..1316; 1323..1331; 1565..1571; 1583..1587; 1619..1628; 1643..1652
Beta Strand
1039..1042; 1282..1284; 1290..1292; 1561..1564; 1572..1577; 1589..1593; 1596..1599; 1601..1608; 1615..1617; 1632..1635; 1639..1642
3D Structure
NMR spectroscopy (2); X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
1417..1448; Basic and acidic residues
Domain (CC)
Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of nucleotide-free CDC42 and promotes binding of GTP-bound CDC42. Phosphorylation of Ser-1443 prevents interaction between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free CDC42 on both C1 and C2..
Domain (FT)
44..159; Calponin-homology (CH); 679..712; WW; 745..774; IQ 1; 775..804; IQ 2; 805..834; IQ 3; 835..864; IQ 4; 1020..1269; Ras-GAP
Region
956..1274; C1; 1276..1657; C2; 1410..1448; Disordered