Protein detail

GALR1

Galanin receptor type 1 (GAL1-R) (GALR-1)

Entry name GALR1	UniProt ID P47211	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Galanin receptor type 1 (GAL1-R) (GALR-1)

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

37..57; Helical; Name=1; 71..91; Helical; Name=2; 110..131; Helical; Name=3; 152..172; Helical; Name=4; 201..221; Helical; Name=5; 249..269; Helical; Name=6; 272..292; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000166573

Entrez Gene Symbol

GALR1

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificAstrocytes

Function & Pathway7

Protein Function

G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (2)

Molecular Function (5)

Biological Process (3)

KEGG

hsa04080 Neuroactive ligand-receptor interaction

Reactome (5)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence58

Ligand-Receptor Signaling (53)

53 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	Cellinker	No	Yes	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
receptor	receptor	EMBRACE	No	Yes	No	Yes	No
gpcr	receptor	GPCRdb	No	Yes	No	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GALR1	P47211	GNAO	P09471	Yes	Yes	No	HINTSIGNOR	HINT:35594396 SIGNOR:31160049
GALR1	P47211	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
GALR1	P47211	GNAI1	P63096	Yes	Yes	No	SIGNOR	SIGNOR:31160049

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
GALR1	GALR1 GPR151	P47211 Q8TDV0	1:1	CellPhoneDB	CellPhoneDB:GALR1

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	ELISA	1	40784529

Sequence, Structure & Domains9

Sequences

Length

349

Mass

38,953

Sequence

MELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV

3D Structural Models

Turn

139..142

Helix

33..60; 69..97; 104..138; 143..146; 149..166; 168..173; 194..208; 210..230; 236..259; 261..271; 279..302; 308..317

Beta Strand

98..100; 175..177; 186..188; 303..307

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance1

Drugs (2)

TESTOSTERONE BUPROPION HYDROCHLORIDE

Supporting Publications1

PMID	Title	Abstract
37353784	m6A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma.	IGF2BP2 was preferentially secreted by exosomes in the LUAD_IGF2BP2 subpopulation, which was absorbed by the En_IGF2BP2 subpopulation in the tumor microenvironment.