Protein detail
GBRA2
Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2) (GABAAR subunit alpha-2)
Protein symbol GBRA2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 4 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2) (GABAAR subunit alpha-2)
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
250..270; Helical; 281..300; Helical; 312..332; Helical; 421..441; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0005886 plasma membrane
- GO:0030424 axon
- GO:0030672 synaptic vesicle membrane
- GO:0032590 dendrite membrane
- GO:0034707 chloride channel complex
- GO:0043005 neuron projection
- GO:0043025 neuronal cell body
- GO:0045202 synapse
- GO:0060077 inhibitory synapse
- GO:0098794 postsynapse
- GO:0098982 GABA-ergic synapse
- GO:0099634 postsynaptic specialization membrane
- GO:1902495 transmembrane transporter complex
- GO:1902711 GABA-A receptor complex
Molecular Function
- GO:0004890 GABA-A receptor activity
- GO:0005254 chloride channel activity
- GO:0005515 protein binding
- GO:0008503 benzodiazepine receptor activity
- GO:0022851 GABA-gated chloride ion channel activity
- GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
- GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process
KEGG
Reactome
Canonical Pathways
M66 Pid myc activ pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
34 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ion_channel | ion_channel | DGIdb | No | Yes | No | Yes | No |
| ion_channel | ion_channel | Almen2009 | No | Yes | No | Yes | No |
| ligand_gated | ion_channel | Almen2009 | No | Yes | No | Yes | No |
| ligand_gated | ion_channel | Surfaceome | No | Yes | No | Yes | No |
| transporter | transporter | OmniPath | No | Yes | No | Yes | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PCD19 | Q8TAB3 | GBRA2 | P47869 | Yes | Yes | No | SIGNOR | SIGNOR:29360992 |
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GABA-A (a2-b1-g2) receptor | GABRA2GABRB1GABRG2 | P18505P18507P47869 | 2:1:2 | SIGNORComplexPortal | SIGNOR:SIGNOR-C331intact:EBI-48439579 | 3535502029950725344179301475529218790874 |
| GABA-A receptoralpha2-beta2-gamma2 | GABRA2GABRB2GABRG2 | P18507P47869P47870 | 1:2:2 | ComplexPortal | intact:EBI-48423915 | 3535502029950725344179301475529218790874 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureMicrofluidics-Based Methods | Western blotting|FACSWestern blottingMass spectrometrySmall R sequencing (Illumi HiSeq 2000 (Solexa) | 8 | 2146547236062905366350603700501537084607376039873764703337812687 |
Sequence, Structure & Domains
Sequences
Length
451
Mass
51,326
Sequence
MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P47869-1; Sequence=Displayed; Name=2; IsoId=P47869-2; Sequence=VSP_054277, VSP_054278
Alternative Sequence
1..85; MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDM -> MRLKITLPSLREFLTDFWMVTIIGLDQDWE (in isoform 2); 353; K -> KSPSIKAEGITLTYNSVKAILQGAKLIWSKYIAFSWPSLFQEKTLEYLEKWMDCLTFKQSS (in isoform 2)
3D Structural Models
Turn
50..52; 59..63; 82..85; 191..193
Helix
39..49; 115..118; 170..172; 203..205; 251..256; 258..268; 269..273; 279..300; 314..337; 416..439
Beta Strand
66..77; 86..98; 109..113; 119..121; 126..128; 131..133; 139..141; 144..153; 156..165; 179..188; 194..200; 206..208; 216..232; 235..248; 302..304
3D Structure
Electron microscopy (8)
Domain & Motif Annotations
Domain (CC)
The extracellular domain contributes to synaptic contact formation.; DOMAIN: The GABA-binding pockets are located at the interface between neighboring alpha and beta subunits.; DOMAIN: GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.
Protein Families
- Ligand-gated ion channel (TC 1.A.9) family
- Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
- GABRA2 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
Clinical Relevance
Related Diseases
Biomarker
Discontinued in Phase 2; Phase 2; Approved; Investigative; Terminated
Drugs
GLUTETHIMIDEBREXANOLONETEMAZEPAMMIDAZOLAM HYDROCHLORIDEDIMDAZENILESZOPICLONESECOBARBITAL SODIUMPROPOFOLBUTALBITALETHCHLORVYNOLISOFLURANEDIAZEPAMGANAXOLONECLONAZEPAMTALBUTALTRIAZOLAMQUAZEPAMMEPHOBARBITALFLUMAZENILPAGOCLONEFLUDIAZEPAMAZD7325ADINAZOLAMCLORAZEPATEBUTABARBITAL SODIUMCENOBAMATEZOPICLONEBUTABARBITALALPRAZOLAMMETHAQUALONE HYDROCHLORIDEHALAZEPAMESTAZOLAMFLURAZEPAMMEPROBAMATEPENTOBARBITAL SODIUMCHLORDIAZEPOXIDEACAMPROSATE CALCIUMNITRAZEPAMMETHOHEXITAL SODIUMCHLORDIAZEPOXIDE HYDROCHLORIDELORAZEPAMCINOLAZEPAMHEXOBARBITALPRAZEPAMTHIOPENTAL SODIUMFLURAZEPAM HYDROCHLORIDETHIAMYLAL SODIUMBUTOBARBITALTETRAZEPAMOXAZEPAMNORCLOBAZAMCLOBAZAMTRICLOFOS SODIUMGABOXADOLMETHARBITALMETHYPRYLONCLORAZEPATE DIPOTASSIUMHALOTHANEFLUNITRAZEPAMCOCAINEDESFLURANEBROMAZEPAMSECOBARBITALZOLPIDEM TARTRATETOPIRAMATEAZD6280CHLORMETHIAZOLEREMIMAZOLAMPRIMIDONELOREDIPLONETOMIDATEOCINAPLONTHIOPENTALENFLURANE[3H]AZIETOMIDATEMETHOXYFLURANEADIPIPLONREMIMAZOLAM BESYLATEABP-700ZURANOLONECLOTIAZEPAMRESEQUINILMETHAQUALONESEVOFLURANEETAZOLATEPHENOBARBITALCIPEPOFOLDARIGABATPADSEVONILNULLETIFOXINE
Interaction Protein
ENSG00000146648
Interaction Count
1
Interaction Dataset
intact_biogrid