Protein detail

SC6A8

Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8)

Entry name SC6A8	UniProt ID P48029	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 12	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8)

Protein Function (5)

Predicted intracellular proteins
Transporters:Electrochemical Potential-driven transporters
Disease related genes
FDA approved drug targets:Small molecule drugs
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism

Transmembrane

61..81; Helical; 88..108; Helical; 139..159; Helical; 231..251; Helical; 270..290; Helical; 305..325; Helical; 342..362; Helical; 395..415; Helical; 445..465; Helical; 480..500; Helical; 521..541; Helical; 561..581; Helical

Transmembrane Count

Ensembl

ENSG00000130821

Entrez Gene Symbol

SLC6A8

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization5

Tissue SpecificintestineCell SpecificEnterocytesSingle-Nuclei Brain Specifichippocampal CA4Secretome LocationIntracellular and membraneSecretome FunctionNo annotated function

Function & Pathway6

Protein Function (5)

Predicted intracellular proteins
Transporters:Electrochemical Potential-driven transporters
Disease related genes
FDA approved drug targets:Small molecule drugs
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism

Cellular Component (3)

Molecular Function (4)

Biological Process (3)

Reactome (2)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence28

Ligand-Receptor Signaling (25)

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	Yes	No	No
cell_surface_ligand	cell_surface_ligand	CellPhoneDB	Yes	No	Yes	No	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	Yes	No	No
transporter	transporter	Surfaceome	No	Yes	Yes	No	No
slc6	transporter	Surfaceome	No	Yes	Yes	No	No
slc	transporter	Surfaceome	No	Yes	Yes	No	No
transporter	transporter	OmniPath	No	Yes	Yes	No	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	No	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	Yes	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
JAK2	O60674	SC6A8	P48029	Yes	No	Yes	SIGNOR	SIGNOR:22407360

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
GABA_byGAD2_and_SLC6A8	GAD2 SLC6A8	P48029 Q05329	1:1	CellPhoneDBCellChatDB	CellPhoneDB:GABA_byGAD2_and_SLC6A8

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingMORPHELISA	4	38113368 28680152 36497184 33592500

Sequence, Structure & Domains9

Sequences

Length

635

Mass

70,523

Sequence

MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=CRT1; IsoId=P48029-1; Sequence=Displayed; Name=2; Synonyms=CRT2, SLC6A8B; IsoId=P48029-2; Sequence=VSP_043917, VSP_043918, VSP_043919, VSP_043920; Name=3; Synonyms=SLC6A8C; IsoId=P48029-3; Sequence=VSP_043916; Name=4; IsoId=P48029-4; Sequence=VSP_046316

Alternative Sequence

1..365; Missing (in isoform 3); 1..259; MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGK -> MLPTLQIQGPAAFAPGDRGPGRHCPFPVPITPTGALLPVSDSCDSLVDLVWPSVTYLALGTQSRVWPHPLGAPGQAGESPEQRRQCLELWDMASSLGDKVPRAACGKRGQTVWQLHLACLCLAQFHSPPAQPPPLSRRGGGPDPDPISRSLPGPPTPALPTHSYSSHSPRAPRLLSPLRRAPRGSPAPHRHASLQTNEAPRELPHCTWPGLPGRSLAPSFLWREPWLGGQWGPLNIPARKGDRRRWEWGCEGGGATASAEQPGPQ (in isoform 2); 1..115; Missing (in isoform 4); 417; S -> SQVCMGLWDREPGGGRREGCRQGKGWRRCGDRPELPWP (in isoform 2); 464; D -> DVSGVGGLPVTSGGRLPSSLTGLCPQ (in isoform 2); 498; Y -> YGRSWLRAGLGDGGGEGRSPAWPSRLTSPQ (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (3)

Domain & Motif Annotations

Region

1..28; Disordered

Protein Families (2)

Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
SLC6A8 subfamily

Sequence Similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily.

Clinical Relevance5

Related Diseases

Malignant digestive organ neoplasm

Biomarker

Phase 1

Interaction Protein

ENSG00000127022

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications2

PMID	Title	Abstract
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available