Protein detail
S6A11
Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11)
Protein symbol S6A11 | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11)
Protein Class
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
59..79; Helical; Name=1; 87..106; Helical; Name=2; 131..151; Helical; Name=3; 226..244; Helical; Name=4; 253..270; Helical; Name=5; 306..323; Helical; Name=6; 335..356; Helical; Name=7; 389..408; Helical; Name=8; 438..456; Helical; Name=9; 473..493; Helical; Name=10; 514..533; Helical; Name=11; 553..571; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
GAT3
Gene Description
Solute carrier family 6 member 11
Chromosome
3
Position
10816201-10940714
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-71288 creatine metabolism
- R-hsa-888590 gaba synthesis release reuptake and degradation
- R-hsa-71291 metabolism of amino acids and derivatives
- R-hsa-112316 neuronal system
- R-hsa-112310 neurotransmitter release cycle
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-442660 slc mediated transport of neurotransmitters
- R-hsa-112315 transmission across chemical synapses
- R-hsa-382551 transport of small molecules
Canonical Pathways
- M231 Pid kit pathway
- M195 Pid cmyb pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | DGIdb | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | No | No | No | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| slc6 | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38942343 |
Sequence, Structure & Domains
Sequences
Length
632
Mass
70,606
Sequence
MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48066-1; Sequence=Displayed; Name=2; IsoId=P48066-2; Sequence=VSP_056539
Alternative Sequence
209..632; Missing (in isoform 2)
3D Structural Models
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Region
1..41; Disordered
Protein Families
- Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
- SLC6A11 subfamily
Sequence Similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily.