Protein detail

SC6A9

Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9)

Protein symbol SC6A9	UniProt ID P48067	EVMP score 0.25
Frequency 1	Transmembrane count 12	Protein classification Disease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9)

Protein Class

Disease related genesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Predicted intracellular proteins
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism

Transmembrane

109..129; Helical; Name=1; 136..156; Helical; Name=2; 188..208; Helical; Name=3; 286..306; Helical; Name=4; 315..335; Helical; Name=5; 360..380; Helical; Name=6; 407..427; Helical; Name=7; 450..470; Helical; Name=8; 506..526; Helical; Name=9; 530..550; Helical; Name=10; 570..590; Helical; Name=11; 610..630; Helical; Name=12

Transmembrane Count

Ensembl

ENSG00000196517

Entrez Gene Symbol

SLC6A9

Gene Synonym

GlyT-1GLYT1

Gene Description

Solute carrier family 6 member 9

Chromosome

Position

43991500-44031467

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificmedium spiny neuronBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Predicted intracellular proteins
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

15 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SLC6A9	PRKCB	P05771	T	590	phosphorylation	SIGNOR	SIGNOR:21864610
SLC6A9	PRKCB	P05771	T	276	phosphorylation	SIGNOR	SIGNOR:21864610
SLC6A9	PRKCB	P05771	S	625	phosphorylation	SIGNOR	SIGNOR:21864610
SLC6A9	PRKCB	P05771	T	19	phosphorylation	SIGNOR	SIGNOR:21864610
SLC6A9	PRKCB	P05771	S	239	phosphorylation	SIGNOR	SIGNOR:21864610
SLC6A9	PRKCA	P17252	T	276	phosphorylation	KEASIGNOR	KEA:7595479 SIGNOR:21864610
SLC6A9	PRKCA	P17252	S	239	phosphorylation	KEASIGNOR	KEA:7595479 SIGNOR:21864610
SLC6A9	PRKCA	P17252	S	625	phosphorylation	KEASIGNOR	KEA:7595479 SIGNOR:21864610
SLC6A9	PRKCA	P17252	T	590	phosphorylation	KEASIGNOR	KEA:7595479 SIGNOR:21864610
SLC6A9	PRKCA	P17252	T	19	phosphorylation	KEASIGNOR	KEA:7595479 SIGNOR:21864610

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Ligand-Receptor Signaling

28 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	DGIdb	No	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_surface_ligand	cell_surface_ligand	CellPhoneDB	Yes	No	No	No	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCB	P05771	SC6A9	P48067	Yes	No	Yes	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:21864610 SIGNOR:21864610
KPCA	P17252	SC6A9	P48067	Yes	No	Yes	PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper	ProtMapper:21864610 HPRD:7595479 SIGNOR:21864610 ProtMapper:7595479 KEA:7595479

Protein Complex Composition

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
Glycine_bySHMT1_and_SLC6A9	SHMT1 SLC6A9	P34896 P48067	1:1	CellPhoneDBCellChatDB	CellPhoneDB:Glycine_bySHMT1_and_SLC6A9
Glycine_bySHMT2_and_SLC6A9	SHMT2 SLC6A9	P34897 P48067	1:1	CellPhoneDBCellChatDB	CellPhoneDB:Glycine_bySHMT2_and_SLC6A9
	LSM2 LSM4 LSM6 LSM7 LSM8 MEPCE PRPF3 PRPF4 SART3 SLC6A9 SLTM SNRPD2	O43172 O43395 O95777 P48067 P62312 P62316 Q15020 Q7L2J0 Q9NWH9 Q9UK45 Q9Y333 Q9Y4Z0	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7587

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	30550287

Sequence, Structure & Domains

Sequences

Length

706

Mass

78,260

Sequence

MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=GlyT-1C; IsoId=P48067-1; Sequence=Displayed; Name=GlyT-1A; IsoId=P48067-2; Sequence=VSP_006270; Name=GlyT-1B; IsoId=P48067-3; Sequence=VSP_006271

Alternative Sequence

1..83; MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLLPQLMAQHSLAMAQ -> MVGKGAKGML (in isoform GlyT-1A); 29..82; Missing (in isoform GlyT-1B)

3D Structural Models

Turn

103..105; 272..274; 373..375; 550..552; 597..601; 633..636; 663..665

Helix

106..117; 120..123; 125..132; 135..137; 139..148; 150..164; 170..173; 176..179; 180..209; 264..271; 288..306; 309..311; 313..319; 322..334; 340..348; 358..372; 378..383; 392..425; 439..448; 454..488; 491..494; 497..512; 513..516; 520..530; 535..549; 553..564; 570..593; 607..621; 623..632; 640..648; 659..661

Beta Strand

212..214; 218..220; 258..260; 278..281; 335..339; 354..357; 429..433; 435..437; 451..453; 532..534; 655..657

3D Structure

Electron microscopy (7); X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

7..18; Low complexity

Region

1..26; Disordered; 695..706; Essential for interaction with EXOC1

Protein Families

Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
SLC6A9 subfamily

Sequence Similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.

Clinical Relevance

Disease Involvement

Disease variant

Related Diseases

Dementia Psychotic disorder Schizophrenia

Biomarker

Investigative; Phase 2; Phase 3

Drugs

PF-03463275 ORG-25935 ORGANON BITOPERTIN (R)-NFPS CHEMBL:CHEMBL59821 METHAMPHETAMINE SSR-103800

Antibody

HPA013977