Protein detail
MAOX
NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1)
Protein symbol MAOX | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1)
Protein Class
EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
- Enzymes
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
Malic enzyme 1
Chromosome
6
Position
83210402-83431051
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Enzymes
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0000287 magnesium ion binding
- GO:0004470 malic enzyme activity
- GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity
- GO:0005515 protein binding
- GO:0008948 oxaloacetate decarboxylase activity
- GO:0009055 electron transfer activity
- GO:0030145 manganese ion binding
- GO:0042802 identical protein binding
- GO:0043531 ADP binding
- GO:0050661 NADP binding
- GO:0051287 NAD binding
Biological Process
KEGG
Reactome
- R-hsa-1428517 aerobic respiration and respiratory electron transport
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9711123 cellular response to chemical stress
- R-hsa-9755511 keap1 nfe2l2 pathway
- R-hsa-556833 metabolism of lipids
- R-hsa-9759194 nuclear events mediated by nfe2l2
- R-hsa-70268 pyruvate metabolism
- R-hsa-400206 regulation of lipid metabolism by pparalpha
- R-hsa-9861718 regulation of pyruvate metabolism
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ME1 | NEK1 | Q96PY6 | S | 336 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NEK1 | Q96PY6 | MAOX | P48163 | Yes | No | Yes | SIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:31735643ProtMapper:31735643SIGNOR:31735643 |
| SIR6 | Q8N6T7 | MAOX | P48163 | Yes | No | Yes | SIGNOR | SIGNOR:31735643 |
| PGAM5 | Q96HS1 | MAOX | P48163 | Yes | Yes | No | SIGNOR | SIGNOR:31735643 |
| THIL | P24752 | MAOX | P48163 | Yes | Yes | No | SIGNOR | SIGNOR:31735643 |
Protein Complex Composition
51 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| BRME1HSF2BP | O75031Q0VDD7 | 1:1 | PDB | PDB:8a51 | ||
| CA2CTSOLYPLA1NME1 | O75608P00918P15531P43234 | 0:0:0:0 | hu.MAP2 | |||
| FBXO7POMPPSMB10PSMB3PSMB9PSME1PSME2PSME4PSMF1PSMG1PSMG2PSMG3PSMG4 | O95456P28065P40306P49720Q06323Q14997Q5JS54Q92530Q969U7Q9BT73Q9UL46Q9Y244Q9Y3I1 | 0:0:0:0:0:0:0:0:0:0:0:0:0 | hu.MAP | |||
| NME1NME2SOD1UROD | P00441P06132P15531P22392 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_201 | ||
| NME1RGNSOD1 | P00441P15531Q15493 | 0:0:0 | hu.MAP | |||
| CA2NME1 | P00918P15531 | 0:0 | hu.MAP2 | |||
| CA2IDI1NME1 | P00918P15531Q13907 | 0:0:0 | hu.MAP2 | |||
| CA2IDI1NAXDNME1PDCD6IP | P00918P15531Q13907Q8IW45Q8WUM4 | 0:0:0:0:0 | hu.MAP2 | |||
| CSTBNUDCPPME1TJAP1 | P04080Q5JTD0Q9Y266Q9Y570 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_339 | ||
| ALDH2ME1NUTF2PGM1 | P05091P36871P48163P61970 | 0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 37330168 |
Sequence, Structure & Domains
Sequences
Length
572
Mass
64,150
Sequence
MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFVRSQMYSTDYDQILPDCYSWPEEVQKIQTKVDQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48163-1; Sequence=Displayed; Name=2; IsoId=P48163-2; Sequence=VSP_057051
Alternative Sequence
1..75; Missing (in isoform 2)
3D Structural Models
Turn
22..24; 41..43; 157..159; 260..262; 268..270; 424..426
Helix
16..19; 27..29; 32..37; 51..64; 68..79; 83..91; 94..101; 105..111; 113..116; 127..129; 133..137; 163..167; 168..181; 185..187; 200..204; 218..236; 249..259; 271..288; 292..294; 304..319; 324..329; 349..352; 364..371; 388..397; 410..412; 417..423; 454..456; 458..468; 475..487; 491..495; 503..505; 506..523; 536..541; 561..564
Beta Strand
122..126; 147..151; 153..156; 188..194; 240..244; 263..267; 297..301; 331..335; 374..378; 402..405; 429..434; 529..531
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Protein Families
Malic enzymes family
Sequence Similarities
Belongs to the malic enzymes family.
Clinical Relevance
Antibody