Protein detail
PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)
Entry name PI42A | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 5 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)
Protein Class (4)
EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
PIP5K2APIP5KIIAPIP5KIIalpha
Gene Description
Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
Chromosome
10
Position
22534854-22714578
Supporting publications (n)
5
EVMP confidence score
0.38
Fluorescence & Localization3
Tissue SpecifictestisCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificependymal cell
Function & Pathway8
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Cellular Component (7)
Molecular Function (5)
Biological Process (3)
KEGG (4)
Reactome (11)
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-556833 metabolism of lipids
- R-hsa-199418 negative regulation of the pi3k akt network
- R-hsa-1483257 phospholipid metabolism
- R-hsa-6811555 pi5p regulates tp53 acetylation
- R-hsa-1483255 pi metabolism
- R-hsa-5633007 regulation of tp53 activity
- R-hsa-6804758 regulation of tp53 activity through acetylation
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-1660499 synthesis of pips at the plasma membrane
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Canonical Pathways
M67 Pid arf6 trafficking pathway
Mediation Categories (4)
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence21
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PIP4K2A | CSNK2A1 | P68400 | S | 304 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:10508590ProtMapper:10508590SIGNOR:10508590phosphoELM:10508590 |
| PIP4K2A | PRKD1 | Q15139 | T | 376 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16563698SIGNOR:16563698 |
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCD1 | Q15139 | PI42A | P48426 | Yes | No | Yes | PhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper | ProtMapper:16563698SIGNOR:16563698 |
| CSK21 | P68400 | PI42A | P48426 | Yes | Yes | No | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:10508590phosphoELM:10508590KEA:10508590PhosphoSite:10508590SIGNOR:10508590 |
| ARF6 | P62330 | PI42A | P48426 | Yes | Yes | No | SIGNOR | SIGNOR:14565977 |
Protein Complex Composition (7)
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster272 | PIP4K2APIP4K2BPIP4K2CTMEM205TSR3 | P48426P78356Q6UW68Q8TBX8Q9UJK0 | 1:1:1:1:1 | Compleat | Compleat:HC2153 | 22036573 |
| PIP4K2APIP4K2BPIP4K2CZRANB2 | O95218P48426P78356Q8TBX8 | 0:0:0:0 | hu.MAPhu.MAP2 | |||
| GTF2BGTF2E1GTF2E2GTF2F1GTF2F2HMGB1HSPA8PIP4K2APOLR2APOLR2CPOLR2JTAF1TBPTCEA1TOX2 | P09429P11142P13984P19387P20226P21675P23193P24928P29083P29084P35269P48426P52435Q00403Q96NM4 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC3720 | ||
| PIP4K2A | P48426 | 2 | PDB | PDB:6ospPDB:6ym3PDB:6ux9PDB:6ym4PDB:2ybxPDB:6ym5 | ||
| MEX3BPIP4K2APIP4K2BPIP4K2C | P48426P78356Q6ZN04Q8TBX8 | 0:0:0:0 | hu.MAP2 | |||
| PIP4K2APIP4K2BPIP4K2C | P48426P78356Q8TBX8 | 0:0:0 | hu.MAP | |||
| EAF1PIP4K2APIP4K2BPIP4K2C | P48426P78356Q8TBX8Q96JC9 | 0:0:0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains12
Sequences
Length
406
Mass
46,225
Sequence
MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48426-1; Sequence=Displayed; Name=2; IsoId=P48426-2; Sequence=VSP_056458
Alternative Sequence
1..59; Missing (in isoform 2)
3D Structural Models
Turn
81..83; 169..171; 334..336
Helix
36..52; 63..67; 95..104; 109..117; 149..168; 223..227; 235..240; 249..268; 283..287; 364..366; 390..404
Beta Strand
69..80; 86..94; 122..124; 134..136; 140..147; 178..186; 189..197; 202..204; 207..212; 215..217; 228..230; 232..234; 271..273; 275..282; 340..342; 351..358
3D Structure
X-ray crystallography (15)
Domain & Motif Annotations
Compositional Bias
289..304; Acidic residues
Domain (FT)
33..405; PIPK
Region
59..65; Required for interaction with PIP5K1A; 288..329; Disordered
Clinical Relevance5
Drugs (5)
Interaction Protein (3)
ENSG00000118046ENSG00000166908ENSG00000276293
Interaction Count
3
Interaction Dataset (2)
biogrid_bioplexbiogrid_opencell_bioplex
Supporting Publications5
| PMID | Title | Abstract |
|---|---|---|
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No abstract available |
| 36064647 | Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 40465195 | Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome. | No abstract available |