Protein detail

SL9A3

Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3)

Entry name SL9A3	UniProt ID P48764	EVMP score 0.50
Frequency 1	Transmembrane count 13	Protein classification Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3)

Protein Class

Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Digestive system diseases:Gastrointestinal diseases
FDA approved drug targets:Small molecule drugs

Transmembrane

52..74; Helical; Name=1; 83..102; Helical; Name=2; 112..129; Helical; Name=3; 133..168; Helical; Name=4; 182..203; Helical; Name=5; 206..237; Helical; Name=6; 245..279; Helical; Name=7; 282..304; Helical; Name=8; 307..323; Helical; Name=9; 331..359; Helical; Name=10; 368..389; Helical; Name=11; 403..426; Helical; Name=12; 434..467; Helical; Name=13

Transmembrane Count

Ensembl

ENSG00000066230

Entrez Gene Symbol

SLC9A3

Gene Synonym

NHE-3NHE3

Gene Description

Solute carrier family 9 member A3

Chromosome

Position

470456-524449

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificintestineCell SpecificEnterocytes

Function & Pathway

Protein Function

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Digestive system diseases:Gastrointestinal diseases
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SLC9A3	SGK1	O00141	S	663	phosphorylation	RLIMS-P_ProtMapperdbPTMREACH_ProtMapperProtMapper	ProtMapper:15888551 ProtMapper:27517916dbPTM:-
SLC9A3	RPS6KA3	P51812	S	663	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
SLC9A3	GAST	P01350	S	555	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:23275470

Ligand-Receptor Signaling

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transporter	transporter	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
apical_cell_membrane	plasma_membrane	UniProt_location	No	No	No	No	No

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
	COMPLEX:O43741_P54619_P54646_Q13131_Q9UGI9_Q9UGJ0_Q9Y478	SL9A3	P48764	Yes	No	Yes	SIGNOR	SIGNOR:38047302
SGK1	O00141	SL9A3	P48764	Yes	Yes	No	Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperdbPTMREACH_ProtMapper	ProtMapper:15888551 ProtMapper:27517916 SIGNOR:21054167 ProtMapper:21054167
MAST2	Q6P0Q8	SL9A3	P48764	Yes	Yes	Yes	DOMINOWangSIGNORHPRDSPIKE_LCLit-BM-17	Lit-BM-17:16159897 DOMINO:16159897 SPIKE_LC:16159897 SIGNOR:16159897 HPRD:16159897

Protein Complex Composition

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Sodium/proton exchanger complexNHE3-CHP1 variant	CHP1 SLC9A3	P48764 Q99653	2:2	ComplexPortalPDB	intact:EBI-63256098PDB:7X2UPDB:7x2u	35613257 14755292
Sodium/proton exchanger complexNHE3-CHP2 variant	CHP2 SLC9A3	O43745 P48764	2:2	ComplexPortal	intact:EBI-63466163	35613257 14755292
Sodium/proton exchanger complexNHE3-CHP3 variant	SLC9A3 TESC	P48764 Q96BS2	2:2	ComplexPortal	intact:EBI-63466200	35613257 14755292

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

834

Mass

92,855

Sequence

MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIALWILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKRLESFKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGETVVPSQRARTQIPYSPGTFCRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48764-1; Sequence=Displayed; Name=2; IsoId=P48764-2; Sequence=VSP_053989

Alternative Sequence

452..460; Missing (in isoform 2)

3D Structural Models

Turn

49..51; 116..119; 201..203; 239..241; 318..325; 361..363; 428..430; 661..664

Helix

54..72; 76..79; 84..101; 105..107; 112..115; 120..129; 133..138; 140..147; 149..167; 178..188; 193..196; 197..200; 207..237; 244..275; 276..278; 286..303; 308..317; 329..359; 368..394; 403..410; 417..424; 434..463; 475..494; 501..513; 515..519; 522..536; 618..623; 628..630; 646..660

Beta Strand

637..639

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Compositional Bias

679..691; Basic residues; 717..728; Acidic residues

Domain (CC)

The C-terminal intracellular domain is subject to extensive post-translational modifications and binding partner interactions which regulate transporter activity, scaffolding functions, downstream events and localization.

Region

575..589; Interaction with EZR; 590..667; Interaction with NHERF4; 591..695; Interaction with AHCYL1; 679..728; Disordered; 814..834; Disordered

Protein Families

Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

Sequence Similarities

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

Clinical Relevance

Disease Involvement

Disease variantFDA approved drug targets

Related Diseases

Angina pectoris Breathing abnormality Cardiac arrhythmia Chronic kidney disease Genetic cardiac arrhythmia Irritable bowel syndrome Urinary system disease

Biomarker

Discontinued in Phase 2; Phase 2; Terminated; Approved

Drug Targets

FDA approved drug targets

Drugs

TENAPANOR THERAPEUTIC GLUCOCORTICOID TENAPANOR HYDROCHLORIDE SQUALAMINE LACTATE

Antibody

HPA036493 HPA036669

Interaction Protein

ENSG00000187446

Interaction Count

Interaction Dataset

intact_biogrid