Protein detail
T23O
Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)
Entry name T23O | UniProt ID | EVMP score 0.38 |
Frequency 3 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
- Potential drug targets
- Enzymes
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Ensembl
Entrez Gene Symbol
Gene Synonym
TDOTPH2
Gene Description
Tryptophan 2,3-dioxygenase
Chromosome
4
Position
155854738-155920406
Frequency
3
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificstomach 1Cell SpecificBreast lactating cellsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
- Potential drug targets
- Enzymes
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Cellular Component
Molecular Function
Biological Process
KEGG
Mediation Categories
Clinical-translation mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| TDO2 | IGF1R | P08069 | Y | 146 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
406
Mass
47,872
Sequence
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
3D Structural Models
Turn
141..143; 147..149; 217..220; 298..300
Helix
42..45; 48..51; 58..61; 69..98; 101..103; 105..107; 108..132; 137..140; 144..146; 152..154; 156..165; 169..171; 174..179; 181..183; 186..197; 201..210; 222..242; 248..266; 270..278; 286..297; 302..304; 305..336; 348..352; 357..359; 363..367; 368..371; 375..377; 383..388
Beta Strand
342..345
3D Structure
X-ray crystallography (22)
Domain & Motif Annotations
Protein Families
- Tryptophan 2
- 3-dioxygenase family
Sequence Similarities
Belongs to the tryptophan 2,3-dioxygenase family.
Clinical Relevance
Disease Involvement
Disease variant
Drug Targets
Literature-reported target
Antibody
Interaction Protein
ENSG00000137575ENSG00000151247ENSG00000169093ENSG00000173614
Interaction Count
4
Interaction Dataset
intact_biogrid