Protein detail
TNNI2
Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)
Entry name TNNI2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
AMCD2BDA2BFSSV
Gene Description
Troponin I2, fast skeletal type
Chromosome
11
Position
1838981-1841680
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization1
Function & Pathway7
Protein Function (3)
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence12
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (7)
7 records.
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains12
Sequences
Length
182
Mass
21,339
Sequence
MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48788-1; Sequence=Displayed; Name=2; IsoId=P48788-2; Sequence=VSP_046052
Alternative Sequence
1..5; MGDEE -> MSQCK (in isoform 2)
3D Structural Models
Turn
125..127
Helix
119..124
Beta Strand
106..108
3D Structure
NMR spectroscopy (2)
Domain & Motif Annotations
Region
2..48; Involved in binding TNC; 97..117; Involved in binding TNC and actin
Protein Families
Troponin I family
Sequence Similarities
Belongs to the troponin I family.
Clinical Relevance6
Disease Involvement
Disease variant
Drugs (2)
Interaction Protein (2)
ENSG00000114854ENSG00000173153
Interaction Count
2
Interaction Dataset (2)
intact_biogrid_bioplexintact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38037300 | Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles. | No abstract available |