Protein detail

TNNI2

Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)

Protein symbol
TNNI2
UniProt ID
P48788
EVMP score
0.38
Frequency
1
Transmembrane count
Protein classification
Disease related genesHuman disease related genesPredicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function
  • Disease related genes
  • Human disease related genes:Congenital malformations:Other congenital malformations
  • Predicted intracellular proteins
Ensembl
ENSG00000130598
Entrez Gene Symbol
TNNI2
Gene Synonym
AMCD2BDA2BFSSV
Gene Description
Troponin I2, fast skeletal type
Chromosome
11
Position
1838981-1841680
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
  • Disease related genes
  • Human disease related genes:Congenital malformations:Other congenital malformations
  • Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Other mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Regulatory Interaction Network

0 records.

Protein Complex Composition

7 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
troponin complexTNNC1TNNC2TNNI1TNNI2TNNI3TNNT1TNNT2TNNT3P02585P13805P19237P19429P45378P45379P48788P633161:1:1:1:1:1:1:1CompleatCompleat:HC1693121868601719469118032382108062051566537810850966
ACO2ACTBACTN2ALDOACSGCN1GPD2H1-5MYH2NDUFS4TNNI2TPM2ZFP36O43181O75390P04075P07951P16401P26651P35609P43304P48788P60709Q92616Q99798Q9UKX21:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC4461
ACO2ACTBACTN2ALDOACKMCSGCN1H1-5MYH2MYH8NTPCRTNNI2TNNT3TPM1ZFP36O75390P04075P06732P09493P13535P16401P26651P35609P45378P48788P60709Q92616Q99798Q9BSD7Q9UKX21:1:1:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC7462
ACO2ACTBACTN2ALDOACSGPD2H1-5MYH7MYLK2TNNI2TPM1YWHAZZFP36O75390P04075P09493P12883P16401P26651P35609P43304P48788P60709P63104Q99798Q9H1R31:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC4547
TNNC1TNNI1TNNI2TNNI3TNNT1TRIM63P13805P19237P19429P48788P63316Q969Q11:1:1:1:1:1CompleatCFinderCompleat:HC7232
TNNC1TNNI2P48788P633161:1hu.MAP2PDBPDB:2mkp
NUCB2TNNC1TNNI2P48788P63316P803030:0:0hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Protein Organic Solvent PrecipitationMass spectrometry132384937
Sequence, Structure & Domains

Sequences

Length
182
Mass
21,339
Sequence
MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48788-1; Sequence=Displayed; Name=2; IsoId=P48788-2; Sequence=VSP_046052
Alternative Sequence
1..5; MGDEE -> MSQCK (in isoform 2)

3D Structural Models

Turn
125..127
Helix
119..124
Beta Strand
106..108
3D Structure
NMR spectroscopy (2)

Domain & Motif Annotations

Region
2..48; Involved in binding TNC; 97..117; Involved in binding TNC and actin
Protein Families
Troponin I family
Sequence Similarities
Belongs to the troponin I family.
Clinical Relevance
Disease Involvement
Disease variant
Drugs
TIRASEMTIVRELDESEMTIV
Antibody
CAB018697HPA055938
Interaction Protein
ENSG00000114854ENSG00000173153
Interaction Count
2
Interaction Dataset
intact_biogrid_bioplexintact_biogrid