Protein detail
AGRE5
Adhesion G protein-coupled receptor E5 (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta]
Protein symbol AGRE5 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 7 | Protein classification CD markersG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Adhesion G protein-coupled receptor E5 (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta]
Protein Class
CD markersG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function
- G-protein coupled receptors:Family 2 (B) receptors
- Transporters
- Predicted intracellular proteins
- CD markers
- Predicted secreted proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
553..572; Helical; Name=1; 582..601; Helical; Name=2; 621..642; Helical; Name=3; 654..674; Helical; Name=4; 692..712; Helical; Name=5; 740..760; Helical; Name=6; 767..789; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
CD97TM7LN1
Gene Description
Adhesion G protein-coupled receptor E5
Chromosome
19
Position
14380501-14408725
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificnon-classical monocyte
Function & Pathway
Protein Function
- G-protein coupled receptors:Family 2 (B) receptors
- Transporters
- Predicted intracellular proteins
- CD markers
- Predicted secreted proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
71 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | UniProt_keyword | No | Yes | Yes | Yes | No |
| tetraspanins | receptor | HPMR | No | Yes | Yes | Yes | No |
| tet3 | receptor | HPMR | No | Yes | Yes | Yes | No |
| gpcr | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| adhesion | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| class_b2_adhesion | receptor | GPCRdb | No | Yes | Yes | Yes | No |
| class_b2_adhesion_adhesion | receptor | GPCRdb | No | Yes | Yes | Yes | No |
| class_b2_adhesion_adhesion_adgre | receptor | GPCRdb | No | Yes | Yes | Yes | No |
| adhesion_gpcr | receptor | ICELLNET | No | Yes | Yes | Yes | No |
| cell_adhesion | receptor | ICELLNET | No | Yes | Yes | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| DAF | P08174 | AGRE5 | P48960 | Yes | Yes | No | iTALKSIGNORHINTCellPhoneDB_CellinkerHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellTalkDBFantom5_LRdbconnectomeDB2020LRdb | HINT:11297558connectomeDB2020:10540231SIGNOR:12417446Cellinker:10540231Cellinker:12417446LRdb:12417446HINT:33992645LRdb:11HPRD:10540231CellTalkDB:12417446connectomeDB2020:12417446CellChatDB:31462748HPMR:12417446 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation；Acoustic trapping | Mass spectrometry | 1 | 27487081 |
Sequence, Structure & Domains
Sequences
Length
835
Mass
91,869
Sequence
MGGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASESGI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=EGF(1,2,3,4,5); IsoId=P48960-1; Sequence=Displayed; Name=2; Synonyms=EGF(1,2,5); IsoId=P48960-2; Sequence=VSP_009411; Name=3; Synonyms=EGF(1,2,3,5); IsoId=P48960-3; Sequence=VSP_009412
Alternative Sequence
116..208; Missing (in isoform 2); 160..208; Missing (in isoform 3)
3D Structural Models
Turn
502..504; 643..645; 688..693; 759..761
Helix
109..111; 273..288; 294..310; 320..342; 386..389; 407..409; 420..430; 533..536; 545..571; 573..575; 578..600; 610..641; 652..673; 675..677; 694..725; 732..749; 751..758; 762..764; 765..776; 778..787; 791..800
Beta Strand
34..38; 41..44; 51..55; 67..71; 80..85; 88..93; 97..102; 106..108; 114..116; 224..228; 230..237; 245..247; 249..251; 347..353; 359..365; 371..374; 376..384; 397..403; 436..438; 445..453; 462..467; 491..501; 505..509; 513..519; 522..529; 605..607; 681..685
3D Structure
Electron microscopy (6); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
814..826; Polar residues
Domain (CC)
The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region.; DOMAIN: Binding to chondroitin sulfate is mediated by the fourth EGF domain.
Domain (FT)
22..63; EGF-like 1; 64..115; EGF-like 2; calcium-binding; 116..159; EGF-like 3; calcium-binding; 160..208; EGF-like 4; calcium-binding; 209..257; EGF-like 5; calcium-binding; 349..543; GAIN-B
Region
495..543; GPS; 814..835; Disordered
Protein Families
- G-protein coupled receptor 2 family
- LN-TM7 subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Clinical Relevance
Drug Targets
Literature-reported target
Antibody