Protein detail

AGRE5

Adhesion G protein-coupled receptor E5 (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta]

Protein symbol AGRE5	UniProt ID P48960	EVMP score 0.50
Frequency 1	Transmembrane count 7	Protein classification CD markersG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Class

CD markersG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters

Protein Function

G-protein coupled receptors:Family 2 (B) receptors
Transporters
Predicted intracellular proteins
CD markers
Predicted secreted proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

553..572; Helical; Name=1; 582..601; Helical; Name=2; 621..642; Helical; Name=3; 654..674; Helical; Name=4; 692..712; Helical; Name=5; 740..760; Helical; Name=6; 767..789; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000123146

Entrez Gene Symbol

ADGRE5

Gene Synonym

CD97TM7LN1

Gene Description

Adhesion G protein-coupled receptor E5

Chromosome

Position

14380501-14408725

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificnon-classical monocyte

Function & Pathway

Protein Function

G-protein coupled receptors:Family 2 (B) receptors
Transporters
Predicted intracellular proteins
CD markers
Predicted secreted proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

Molecular Function

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

71 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane_predicted	Phobius	No	No	Yes	Yes	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
DAF	P08174	AGRE5	P48960	Yes	Yes	No	iTALKSIGNORHINTCellPhoneDB_CellinkerHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	HINT:11297558 connectomeDB2020:10540231 SIGNOR:12417446 Cellinker:10540231 Cellinker:12417446 LRdb:12417446 HINT:33992645LRdb:11HPRD:10540231 CellTalkDB:12417446 connectomeDB2020:12417446 CellChatDB:31462748 HPMR:12417446

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
ADGRE2 ADGRE5 DRAM2 NNT TPST1	O60507 P48960 Q13423 Q6UX65 Q9UHX3	0:0:0:0:0	hu.MAP2
ADGRE5 GPRC5B	P48960 Q9NZH0	0:0	hu.MAP
ADGRE2 ADGRE5	P48960 Q9UHX3	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation；Acoustic trapping	Mass spectrometry	1	27487081

Sequence, Structure & Domains

Sequences

Length

835

Mass

91,869

Sequence

MGGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASESGI

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=EGF(1,2,3,4,5); IsoId=P48960-1; Sequence=Displayed; Name=2; Synonyms=EGF(1,2,5); IsoId=P48960-2; Sequence=VSP_009411; Name=3; Synonyms=EGF(1,2,3,5); IsoId=P48960-3; Sequence=VSP_009412

Alternative Sequence

116..208; Missing (in isoform 2); 160..208; Missing (in isoform 3)

3D Structural Models

Turn

502..504; 643..645; 688..693; 759..761

Helix

109..111; 273..288; 294..310; 320..342; 386..389; 407..409; 420..430; 533..536; 545..571; 573..575; 578..600; 610..641; 652..673; 675..677; 694..725; 732..749; 751..758; 762..764; 765..776; 778..787; 791..800

Beta Strand

34..38; 41..44; 51..55; 67..71; 80..85; 88..93; 97..102; 106..108; 114..116; 224..228; 230..237; 245..247; 249..251; 347..353; 359..365; 371..374; 376..384; 397..403; 436..438; 445..453; 462..467; 491..501; 505..509; 513..519; 522..529; 605..607; 681..685

3D Structure

Electron microscopy (6); X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

814..826; Polar residues

Domain (CC)

The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region.; DOMAIN: Binding to chondroitin sulfate is mediated by the fourth EGF domain.

Domain (FT)

22..63; EGF-like 1; 64..115; EGF-like 2; calcium-binding; 116..159; EGF-like 3; calcium-binding; 160..208; EGF-like 4; calcium-binding; 209..257; EGF-like 5; calcium-binding; 349..543; GAIN-B

Region

495..543; GPS; 814..835; Disordered

Protein Families

G-protein coupled receptor 2 family
LN-TM7 subfamily

Sequence Similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Clinical Relevance

Drug Targets

Literature-reported target

Antibody

HPA013707