Protein detail
MRP
MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS)
Entry name MRP | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
F52MacMARCKSMLPMLP1
Gene Description
MARCKS like 1
Chromosome
1
Position
32333839-32336233
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificInnate lymphoid cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellBlood Lineage SpecificT-cellsSecretome LocationSecreted to bloodSecretome FunctionCytokine
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M243 Pid arf 3pathway
- M86 Pid arf6 pathway
- M141 Pid pi3kci pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MARCKSL1 | ATR | Q13535 | S | 71 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper | KEA:18077418 |
| MARCKSL1 | PKM | P14618 | S | 104 | phosphorylation | KEA | KEA:8132675 |
| MARCKSL1 | PKM | P14618 | S | 93 | phosphorylation | KEA | KEA:8132675 |
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ProTalpha C2 complex | ACTBMARCKSL1PTMASET | P06454P49006P60709Q01105 | 0:0:0:0 | CORUM | CORUM:6984 | 29106904 |
| MARCKSL1MRPL30RALBZBTB43 | O43298P11234P49006Q8TCC3 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_214 | ||
| EEF1B2EIF5BHUWE1MARCKSL1PTMA | O60841P06454P24534P49006Q7Z6Z7 | 0:0:0:0:0 | hu.MAP2 | |||
| HNRNPA0HNRNPABMARCKSL1 | P49006Q13151Q99729 | 0:0:0 | hu.MAP | |||
| HNRNPABHNRNPDMARCKSL1 | P49006Q14103Q99729 | 0:0:0 | hu.MAP | |||
| HNRNPABMARCKSL1 | P49006Q99729 | 0:0 | hu.MAP |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometryWestern blottingFlow cytometryMORPH | 6 | 377869183481790628986585383215353208974333709510 |
Sequence, Structure & Domains
Sequences
Length
195
Mass
19,529
Sequence
MGSQSSKAPRGDVTAEEAAGASPAKANGQENGHVKSNGDLSPKGEGESPPVNGTDEAAGATGDAIEPAPPSQGAEAKGEVPPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEIGACSDEGTAQEGKAAATPESQEPQAKGAEASAASEEEAGPQATEPSTPSGPESGPTPASAEQNE
3D Structural Models
Domain & Motif Annotations
Compositional Bias
16..26; Low complexity; 53..64; Low complexity; 76..85; Basic and acidic residues; 86..98; Basic residues; 153..195; Low complexity
Region
1..195; Disordered; 87..110; Effector domain involved in lipid-binding and calmodulin-binding
Protein Families
MARCKS family
Sequence Similarities
Belongs to the MARCKS family.