Protein detail
CX3C1
CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Beta chemokine receptor-like 1) (CMK-BRL-1) (CMK-BRL1) (Fractalkine receptor) (G-protein coupled receptor 13) (V28)
Protein symbol CX3C1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 7 | Protein classification Disease related genesG-protein coupled receptorsHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Beta chemokine receptor-like 1) (CMK-BRL-1) (CMK-BRL1) (Fractalkine receptor) (G-protein coupled receptor 13) (V28)
Protein Class
Disease related genesG-protein coupled receptorsHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteins
Protein Function
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Potential drug targets
- G-protein coupled receptors:GPCRs excl olfactory receptors
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Transmembrane
32..59; Helical; Name=1; 70..90; Helical; Name=2; 104..125; Helical; Name=3; 143..167; Helical; Name=4; 196..215; Helical; Name=5; 232..256; Helical; Name=6; 274..297; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
CCRL1CMKBRL1CMKDR1GPR13V28
Gene Description
C-X3-C motif chemokine receptor 1
Chromosome
3
Position
39263495-39281735
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecifictestisCell SpecificLate spermatidsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function
Function & Pathway
Protein Function
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Potential drug targets
- G-protein coupled receptors:GPCRs excl olfactory receptors
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component
Molecular Function
- GO:0004930 G protein-coupled receptor activity
- GO:0004950 chemokine receptor activity
- GO:0005515 protein binding
- GO:0008528 G protein-coupled peptide receptor activity
- GO:0016493 C-C chemokine receptor activity
- GO:0016495 C-X3-C chemokine receptor activity
- GO:0019957 C-C chemokine binding
- GO:0019960 C-X3-C chemokine binding
- GO:0031737 CX3C chemokine receptor binding
Biological Process
KEGG
Reactome
- R-hsa-380108 chemokine receptors bind chemokines
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-418594 g alpha i signalling events
- R-hsa-5663205 infectious disease
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-9820952 respiratory syncytial virus infection pathway
- R-hsa-9820960 respiratory syncytial virus rsv attachment and entry
- R-hsa-9833110 rsv host interactions
- R-hsa-372790 signaling by gpcr
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
67 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
| receptor | receptor | Cellinker | No | Yes | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | CellCall | No | Yes | No | Yes | No |
| receptor | receptor | iTALK | No | Yes | No | Yes | No |
| cytokine | receptor | iTALK | No | Yes | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| X3CL1 | P78423 | CX3C1 | P49238 | Yes | Yes | No | iTALKKirouac2010KEGG-MEDICUSGuide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDDLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdb | Cellinker:11432858Cellinker:9390561LRdb:10699158SPIKE_LC:16189514connectomeDB2020:9931005scConnect:14607932connectomeDB2020:9390561SIGNOR:11432858HINT:9931005Cellinker:14607932HPRD:9390561HPRD:9931005HPMR:11432858InnateDB:9931005HINT:23125415Guide2Pharma:14607932connectomeDB2020:11432858ICELLNET:22633458Cellinker:9931005InnateDB:9390561Lit-BM-17:10488147DIP:10488147Lit-BM-17:9931005connectomeDB2020:14607932Cellinker:28389721 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
355
Mass
40,396
Sequence
MDQFPESVTENFEYDDLAEACYIGDIVVFGTVFLSIFYSVIFAIGLVGNLLVVFALTNSKKPKSVTDIYLLNLALSDLLFVATLPFWTHYLINEKGLHNAMCKFTTAFFFIGFFGSIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAAPQFMFTKQKENECLGDYPEVLQEIWPVLRNVETNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKAKAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFPSCDMRKDLRLALSVTETVAFSHCCLNPLIYAFAGEKFRRYLYHLYGKCLAVLCGRSVHVDFSSSESQRSRHGSVLSSNFTYHTSDGDALLLL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P49238-1; Sequence=Displayed; Name=2; IsoId=P49238-2; Sequence=VSP_009681; Name=3; IsoId=P49238-3; Sequence=VSP_009682; Name=4; IsoId=P49238-4; Sequence=VSP_044595
Alternative Sequence
1; M -> MREPLEALKLADLDFRKSSLASGWRMASGAFTM (in isoform 2); 1; M -> MASGAFTM (in isoform 3); 1; M -> MREPLEAFKLADLDFRKSSLASGWRMASGAFTM (in isoform 4)
3D Structural Models
Turn
142..144; 165..167; 224..226; 289..291
Helix
31..56; 65..91; 99..131; 134..139; 146..161; 162..164; 181..184; 187..200; 202..220; 228..258; 267..288; 292..296; 298..309
Beta Strand
58..61; 172..176
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
Age-related macular degeneration