Protein detail
RPIA
Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase)
Entry name RPIA | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 4 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (6)
- ENZYME proteins:Isomerase
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of nucleotide metabolism
- Potential drug targets
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Description
Ribose 5-phosphate isomerase A
Chromosome
2
Position
88691673-88750929
Supporting publications (n)
4
EVMP confidence score
0.38
Fluorescence & Localization3
Tissue SpecifictestisCell SpecificChoroid plexus epithelial cells
Function & Pathway7
Protein Function (6)
- ENZYME proteins:Isomerase
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of nucleotide metabolism
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
KEGG (4)
Reactome (4)
Mediation Categories (2)
Clinical-translation mediationMetabolism mediation
Relations & Evidence7
Ligand-Receptor Signaling (3)
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (3)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains7
Sequences
Length
311
Mass
33,269
Sequence
MQRPGPFSTLYGRVLAPLPGRAGGAASGGGGNSWDLPGSHVRLPGRAQSGTRGGAGNTSTSCGDSNSICPAPSTMSKAEEAKKLAGRAAVENHVRNNQVLGIGSGSTIVHAVQRIAERVKQENLNLVCIPTSFQARQLILQYGLTLSDLDRHPEIDLAIDGADEVDADLNLIKGGGGCLTQEKIVAGYASRFIVIADFRKDSKNLGDQWHKGIPIEVIPMAYVPVSRAVSQKFGGVVELRMAVNKAGPVVTDNGNFILDWKFDRVHKWSEVNTAIKMIPGVVDTGLFINMAERVYFGMQDGSVNMREKPFC
Domain & Motif Annotations
Compositional Bias
22..32; Gly residues; 57..67; Polar residues
Region
22..67; Disordered
Protein Families
Ribose 5-phosphate isomerase family
Sequence Similarities
Belongs to the ribose 5-phosphate isomerase family.
Clinical Relevance5
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No abstract available |
| 36982312 | Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |
| 38716512 | Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics. | No abstract available |