Protein detail
FAS
Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]
Protein symbol FAS | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification Cancer-related genesEnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]
Protein Class
Cancer-related genesEnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- ENZYME proteins:Lyases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym
FASSDR27X1
Gene Description
Fatty acid synthase
Chromosome
17
Position
82078338-82098294
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificAdipocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cellSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion
Function & Pathway
Protein Function
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- ENZYME proteins:Lyases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
- GO:0003723 RNA binding
- GO:0004312 fatty acid synthase activity
- GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity
- GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity
- GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
- GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
- GO:0005515 protein binding
- GO:0016297 fatty acyl-[ACP] hydrolase activity
- GO:0019171 (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
- GO:0031177 phosphopantetheine binding
- GO:0045296 cadherin binding
- GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity
Biological Process
KEGG
Reactome
- R-hsa-2426168 activation of gene expression by srebf srebp
- R-hsa-163765 chrebp activates metabolic gene expression
- R-hsa-9918487 dengue virus genome translation and replication
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-8978868 fatty acid metabolism
- R-hsa-75105 fatty acyl coa biosynthesis
- R-hsa-5663205 infectious disease
- R-hsa-163685 integration of energy metabolism
- R-hsa-556833 metabolism of lipids
- R-hsa-8957322 metabolism of steroids
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-196849 metabolism of water soluble vitamins and cofactors
- R-hsa-9024446 nr1h2 and nr1h3 mediated signaling
- R-hsa-9029558 nr1h2 nr1h3 regulate gene expression linked to lipogenesis
- R-hsa-1655829 regulation of cholesterol biosynthesis by srebp srebf
- R-hsa-9006931 signaling by nuclear receptors
- R-hsa-9824446 viral infection pathways
- R-hsa-199220 vitamin b5 pantothenate metabolism
Mediation Categories
Clinical-translation mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| FASN | AASDHPPT | Q9NRN7 | S | 2,156 | phosphorylation | Reactome_ProtMapperProtMapper |
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
8 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| RO52 | P19474 | FAS | P49327 | Yes | No | Yes | SIGNOR | SIGNOR:27758890 |
| ERBB2 | P04626 | FAS | P49327 | Yes | Yes | No | SIGNOR | SIGNOR:27692180 |
| HACD4 | Q5VWC8 | FAS | P49327 | Yes | Yes | No | SIGNOR | SIGNOR:18554506 |
| KAT8 | Q9H7Z6 | FAS | P49327 | Yes | No | Yes | SIGNOR | SIGNOR:27758890 |
| HACD1 | B0YJ81 | FAS | P49327 | Yes | Yes | No | SIGNOR | SIGNOR:18554506 |
| HDAC3 | O15379 | FAS | P49327 | Yes | Yes | No | SIGNOR | SIGNOR:27758890 |
| HACD2 | Q6Y1H2 | FAS | P49327 | Yes | Yes | No | SIGNOR | SIGNOR:18554506 |
| HACD3 | Q9P035 | FAS | P49327 | Yes | Yes | No | SIGNOR | SIGNOR:18554506 |
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CADFASN | P27708P49327 | 0:0 | hu.MAP2 | |||
| FASN | P49327 | 2 | PDB | PDB:9b80PDB:8vloPDB:8vmcPDB:8vmdPDB:8vm7PDB:9b7zPDB:3hhdPDB:4pivPDB:8vm0PDB:8zevPDB:8vg4PDB:8vlpPDB:8vm5PDB:8gkcPDB:8eykPDB:6nnaPDB:8vlePDB:9mj9PDB:2jfdPDB:8vf7PDB:4w9nPDB:8g7xPDB:4z49PDB:1xktPDB:8eyiPDB:5c37PDB:2px6PDB:2jfkPDB:8vm6PDB:4w82 | ||
| CCT2DNAJC19FASNPTGR2 | P49327P78371Q8N8N7Q96DA6 | 0:0:0:0 | hu.MAP | |||
| ARMH3FASNPTGR2 | P49327Q5T2E6Q8N8N7 | 0:0:0 | hu.MAP | |||
| FASNPTGR2 | P49327Q8N8N7 | 0:0 | hu.MAP | |||
| AASDHPPTFASN | P49327Q9NRN7 | 1:1 | PDB | PDB:2cg5 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryWestern blotting | 1 | 37886648 |
Sequence, Structure & Domains
Sequences
Length
2,511
Mass
273,427
Sequence
MEEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSRFDASFFGVHPKQAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEALSRDPETLVGYSMVGCQRAMMANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKPNTSVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTKKSLARRVYATILNAGTNTDGFKEQGVTFPSGDIQEQLIRSLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITRALCATRQEPLLIGSTKSNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPRLLRASGRTPEAVQKLLEQGLRHSQDLAFLSMLNDIAAVPATAMPFRGYAVLGGERGGPEVQQVPAGERPLWFICSGMGTQWRGMGLSLMRLDRFRDSILRSDEAVKPFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQIGLIDLLSCMGLRPDGIVGHSLGEVACGYADGCLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGLSWEECKQRCPPGVVPACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKKVIREPKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAVLKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPLISPLIKWDHSLAWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLARALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDNWVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAGGVHISGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEELQLCKGLVQALQTKVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQLELAQVLAQERPKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVVEVLAGHGHLYSRIPGLLSPHPLLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAALGDPASALSNMVAALREGGFLLLHTLLRGHPLGDIVAFLTSTEPQYGQGILSQDAWESLFSRVSLRLVGLKKSFYGSTLFLCRRPTPQDSPIFLPVDDTSFRWVESLKGILADEDSSRPVWLKAINCATSGVVGLVNCLRREPGGNRLRCVLLSNLSSTSHVPEVDPGSAELQKVLQGDLVMNVYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEEPEAVLKGAKPKLMSAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAGQSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVSGTLPQRMASCLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHNRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG
3D Structural Models
Turn
62..66; 124..126; 370..372; 444..446; 462..464; 528..531; 543..547; 667..669; 686..690; 699..701; 745..748; 939..942; 1082..1085; 1128..1130; 1213..1217; 1253..1255; 1317..1319; 1559..1561; 1660..1663; 1736..1738; 1747..1751; 1784..1788; 1801..1803; 1891..1893; 2068..2070; 2140..2142; 2149..2153; 2294..2296; 2459..2463
Helix
19..28; 44..46; 69..73; 77..92; 97..100; 115..119; 130..135; 139..148; 160..162; 163..176; 194..202; 236..238; 266..280; 284..286; 300..311; 326..329; 333..335; 336..350; 367..369; 416..419; 431..443; 448..456; 508..511; 514..527; 534..539; 549..569; 582..591; 596..612; 627..633; 655..666; 691..698; 719..721; 732..739; 749..751; 768..774; 792..806; 812..814; 831..833; 847..849; 873..877; 888..903; 907..909; 966..969; 987..996; 1003..1005; 1026..1039; 1059..1065; 1132..1149; 1173..1175; 1177..1187; 1195..1199; 1200..1205; 1206..1211; 1218..1220; 1222..1233; 1247..1250; 1256..1260; 1277..1283; 1284..1289; 1305..1307; 1325..1334; 1352..1360; 1365..1369; 1374..1383; 1420..1423; 1424..1433; 1453..1460; 1466..1468; 1491..1499; 1541..1543; 1550..1553; 1573..1579; 1585..1587; 1589..1592; 1630..1632; 1642..1645; 1649..1659; 1679..1690; 1702..1711; 1717..1719; 1728..1735; 1753..1757; 1772..1775; 1796..1799; 1805..1819; 1833..1835; 1836..1845; 1895..1906; 1923..1934; 1949..1962; 1980..1982; 1985..2009; 2022..2025; 2032..2050; 2088..2099; 2127..2134; 2159..2169; 2176..2180; 2184..2192; 2219..2222; 2255..2257; 2258..2263; 2282..2293; 2309..2325; 2343..2352; 2360..2375; 2380..2387; 2393..2407; 2413..2432; 2464..2466; 2483..2485; 2487..2499
Beta Strand
4..13; 16..18; 38..40; 57..59; 101..103; 106..110; 154..158; 181..189; 216..218; 227..235; 243..253; 261..263; 287..291; 313..315; 320..323; 360..362; 373..376; 385..393; 397..406; 422..430; 467..477; 481..484; 492..496; 504..507; 575..579; 592..594; 622..624; 639..643; 645..647; 649..653; 672..675; 677..679; 683..685; 702..704; 710..713; 715..717; 724..729; 757..764; 780..782; 858..865; 867..870; 878..880; 883..885; 912..919; 927..938; 943..948; 951..960; 975..977; 981..983; 984..986; 999..1001; 1008..1012; 1015..1021; 1047..1057; 1070..1072; 1074..1081; 1086..1089; 1092..1101; 1113..1127; 1190..1192; 1236..1246; 1263..1265; 1267..1276; 1293..1296; 1299..1301; 1309..1316; 1336..1347; 1348..1351; 1387..1394; 1397..1404; 1413..1416; 1441..1445; 1469..1474; 1479..1482; 1488..1490; 1502..1507; 1510..1518; 1525..1529; 1531..1537; 1544..1548; 1556..1558; 1562..1570; 1581..1583; 1594..1596; 1602..1606; 1612..1616; 1622..1628; 1633..1635; 1638..1640; 1670..1675; 1676..1678; 1694..1701; 1720..1722; 1723..1726; 1741..1746; 1760..1769; 1779..1781; 1790..1794; 1828..1832; 1849..1857; 1861..1863; 1873..1876; 1885..1890; 1911..1915; 1938..1942; 1946..1948; 1963..1970; 2015..2021; 2056..2060; 2062..2064; 2065..2067; 2075..2077; 2081..2084; 2104..2111; 2230..2233; 2239..2241; 2244..2247; 2268..2271; 2303..2307; 2333..2338; 2390..2392; 2443..2447; 2453..2458; 2468..2470; 2472..2476
3D Structure
Electron microscopy (17); X-ray crystallography (17)
Domain & Motif Annotations
Domain (FT)
1..406; Ketosynthase family 3 (KS3); 838..1108; PKS/mFAS DH; 2121..2198; Carrier
Region
429..817; Acyl and malonyl transferases; 838..966; N-terminal hotdog fold; 981..1108; C-terminal hotdog fold; 1635..1863; Enoyl reductase; 1864..2118; Beta-ketoacyl reductase; 2207..2511; Thioesterase
Clinical Relevance
Disease Involvement
Cancer-related genes
Related Diseases
Biomarker
Phase 2; Approved; Preclinical; Investigative; Phase 3; Phase 1
Drug Targets
Successful target
Drugs
ADRIAMYCINPRETOMANIDPYROGALLOL REDHEXACHLOROPHENELIOTHYRONINECLOZAPINEPACLITAXELGT 389-255GSK2194069CHEMBL:CHEMBL578883CHEMBL:CHEMBL604664ORLISTATCHEMBL:CHEMBL585030EPIGALLOCATECHIN GALLATEDNQXCERULENINSELENIUMRISPERIDONECHEMBL:CHEMBL586937PENTABROMOPHENOLCHEMBL:CHEMBL1255647LORGLUMIDE SODIUMCHEMBL:CHEMBL523200NULLFENTICLORCHEMBL:CHEMBL577862DENIFANSTATANTINEOPLASTIC AGENT
Interaction Protein
ENSG00000100644ENSG00000142208
Interaction Count
2
Interaction Dataset
intact_biogrid