Protein detail
UBE2A
Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)
Protein symbol UBE2A | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-983168 antigen processing ubiquitination proteasome degradation
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-8866654 e3 ubiquitin ligases ubiquitinate target proteins
- R-hsa-597592 post translational protein modification
- R-hsa-8852135 protein ubiquitination
- R-hsa-8866652 synthesis of active ubiquitin roles of e1 and e2 enzymes
Canonical Pathways
- M5887 Naba basement membranes
- M3008 Naba ecm glycoproteins
- M5884 Naba core matrisome
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
12 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| UBE2A | CDK9 | P50750 | S | 120 | phosphorylation | RLIMS-P_ProtMapperREACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:22722497 |
| UBE2A | MAPK14 | Q16539 | S | 120 | phosphorylation | KEA | KEA:17570479 |
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Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
12 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CDK1 | P06493 | UBE2A | P49459 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper | SIGNOR:11953320HPRD-phos:11953320KEA:11953320PhosphoSite:11953320ProtMapper:11953320HPRD:11953320phosphoELM:11953320 |
| CDK9 | P50750 | UBE2A | P49459 | Yes | Yes | No | Sparser_ProtMapperSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapper | ProtMapper:22722497ProtMapper:33281625SIGNOR:22722497 |
| UBE2A | P49459 | PCNA | P12004 | Yes | Yes | No | SIGNORACSN | ACSN:10722742ACSN:19396164ACSN:16611994ACSN:18196958ACSN:19258535ACSN:18006823ACSN:10884424ACSN:12820959ACSN:17652783ACSN:20675655SIGNOR:19706603ACSN:15280666ACSN:20129063ACSN:15340381ACSN:19459846ACSN:18363965ACSN:15169778ACSN:15147722ACSN:18498753ACSN:10721693ACSN:19440234SIGNOR:12226657ACSN:18157158ACSN:19013543 |
| COMPLEX:P22314_P62979 | UBE2A | P49459 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P22314_P62987 | UBE2A | P49459 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG47_P22314 | UBE2A | P49459 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG48_P22314 | UBE2A | P49459 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:A0AVT1_P0CG47 | UBE2A | P49459 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:A0AVT1_P62979 | UBE2A | P49459 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:A0AVT1_P0CG48 | UBE2A | P49459 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 |
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Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
152
Mass
17,315
Sequence
MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWRDC
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P49459-1; Sequence=Displayed; Name=2; IsoId=P49459-2; Sequence=VSP_043852; Name=3; IsoId=P49459-3; Sequence=VSP_043851
Alternative Sequence
1..75; Missing (in isoform 3); 51..80; Missing (in isoform 2)
3D Structural Models
Turn
47..50; 61..64
Helix
4..18; 90..93; 102..114; 124..132; 134..148
Beta Strand
24..28; 35..42; 52..58; 69..72; 85..87
3D Structure
Electron microscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Domain (FT)
4..150; UBC core
Protein Families
Ubiquitin-conjugating enzyme family
Sequence Similarities
Belongs to the ubiquitin-conjugating enzyme family.
Clinical Relevance
Interaction Protein
ENSG00000070950ENSG00000103549ENSG00000155827
Interaction Count
3
Interaction Dataset
intact_biogridbiogrid_opencell