Protein detail

UBE2A

Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)

Protein symbol
UBE2A
UniProt ID
P49459
EVMP score
0.38
Frequency
1
Transmembrane count
Protein classification
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)
Protein Function
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Enzymes
  • Disease related genes
Ensembl
ENSG00000077721
Entrez Gene Symbol
UBE2A
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Enzymes
  • Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
hsa04120 Ubiquitin mediated proteolysis
Reactome
Canonical Pathways
  • M5887 Naba basement membranes
  • M3008 Naba ecm glycoproteins
  • M5884 Naba core matrisome
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence

Enzyme-Mediated Modification

12 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
UBE2ACDK1P06493S120phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:11953320KEA:11953320ProtMapper:11953320HPRD:11953320phosphoELM:11953320
UBE2ACDK1P06493S90phosphorylationHPRDKEAHPRD:11953320KEA:11953320
UBE2ACDK1P06493S45phosphorylationKEAKEA:11953320
UBE2ACDK2P24941S120phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:11953320KEA:11953320ProtMapper:11953320KEA:17570479HPRD:11953320phosphoELM:11953320
UBE2ACDK2P24941S90phosphorylationHPRDKEAHPRD:11953320KEA:11953320
UBE2ACDK2P24941S45phosphorylationKEAKEA:11953320
UBE2ACDK5Q00535S120phosphorylationPhosphoNetworks
UBE2AGSK3BP49841S120phosphorylationPhosphoNetworksKEAKEA:17570479
UBE2AMAPK1P28482S120phosphorylationPhosphoNetworks
UBE2AMAPK8P45983S120phosphorylationPhosphoNetworks
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Ligand-Receptor Signaling

5 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Regulatory Interaction Network

12 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
COMPLEX:A0AVT1_P62987UBE2AP49459YesYesNoSIGNORSIGNOR:34199813
CDK2P24941UBE2AP49459YesYesNophosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_ProtMapperHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phosNetworKIN_KEASIGNOR:11953320HPRD-phos:11953320KEA:11953320ProtMapper:11953320KEA:17570479HPRD:11953320phosphoELM:11953320
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Protein Complex Composition

11 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
RAD6A-KCMF1-UBR4 complexKCMF1UBE2AUBR4P49459Q5T4S7Q9P0J70:0:0CORUMCORUM:678025582440
Ub:E2UBBUBE2AP0CG47P494590:0SIGNORSIGNOR:SIGNOR-C497
Ub:E2UBCUBE2AP0CG48P494590:0SIGNORSIGNOR:SIGNOR-C497
Ub:E2RPS27AUBE2AP49459P629790:0SIGNORSIGNOR:SIGNOR-C497
Ub:E2UBA52UBE2AP49459P629870:0SIGNORSIGNOR:SIGNOR-C497
POMPPSMA1PSMA2PSMA4PSMA6PSMA7PSMB1PSMB2PSMB3PSMB4PSMB5PSMB6PSMB7UBE2AUBR1O14818P20618P25786P25787P25789P28070P28072P28074P49459P49720P49721P60900Q8IWV7Q99436Q9Y2441:1:1:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC9345
POMPUBE2AUBE2V1UGDHULK4O60701P49459Q13404Q96C45Q9Y2440:0:0:0:0Havugimana2012Havugimana2012:C_489
CSE1LTWF1UBE2AUNC45AUSP1WDR5ZBED1ZWILCHO94782O96006P49459P55060P61964Q12792Q9H3U1Q9H9000:0:0:0:0:0:0:0Havugimana2012Havugimana2012:C_551
UBE2AUBR4P49459Q5T4S72:1PDBPDB:8btl
RAD18SLF1SLF2UBE2AP49459Q8IX21Q9BQI6Q9NS910:0:0:0hu.MAP2
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Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry438731868337095103849095833580572
Sequence, Structure & Domains

Sequences

Length
152
Mass
17,315
Sequence
MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWRDC
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P49459-1; Sequence=Displayed; Name=2; IsoId=P49459-2; Sequence=VSP_043852; Name=3; IsoId=P49459-3; Sequence=VSP_043851
Alternative Sequence
1..75; Missing (in isoform 3); 51..80; Missing (in isoform 2)

3D Structural Models

Turn
47..50; 61..64
Helix
4..18; 90..93; 102..114; 124..132; 134..148
Beta Strand
24..28; 35..42; 52..58; 69..72; 85..87
3D Structure
Electron microscopy (1); X-ray crystallography (3)

Domain & Motif Annotations

Domain (FT)
4..150; UBC core
Protein Families
Ubiquitin-conjugating enzyme family
Sequence Similarities
Belongs to the ubiquitin-conjugating enzyme family.
Clinical Relevance
Interaction Protein
ENSG00000070950ENSG00000103549ENSG00000155827
Interaction Count
3
Interaction Dataset
intact_biogridbiogrid_opencell