Protein detail

CXCR3

C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)

Entry name CXCR3	UniProt ID P49682	EVMP confidence score 0.25
Supporting publications (n) 3	Transmembrane count 7	Protein classification CD markersG-protein coupled receptorsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)

Protein Class (3)

CD markersG-protein coupled receptorsPredicted membrane proteins

Protein Function (3)

G-protein coupled receptors:Chemokines and chemotactic factors receptors
CD markers
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

54..80; Helical; Name=1; 90..110; Helical; Name=2; 126..147; Helical; Name=3; 170..189; Helical; Name=4; 213..233; Helical; Name=5; 256..277; Helical; Name=6; 299..321; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000186810

Entrez Gene Symbol

CXCR3

Gene Synonym (6)

CD183CKR-L2CMKAR3GPR9IP10-RMigR

Gene Description

C-X-C motif chemokine receptor 3

Chromosome

Position

71615916-71618511

Supporting publications (n)

EVMP confidence score

0.25

Function & Pathway7

Protein Function (3)

G-protein coupled receptors:Chemokines and chemotactic factors receptors
CD markers
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (4)

Molecular Function (8)

Biological Process (3)

KEGG (3)

Reactome (7)

Mediation Categories (5)

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence70

Ligand-Receptor Signaling (66)

66 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
receptor	receptor	EMBRACE	No	Yes	No	Yes	No
gpcr	receptor	GPCRdb	No	Yes	No	Yes	No
cxc_chemokine	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	HGNC	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CXCL9	Q07325	CXCR3	P49682	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerUniProt_LRdbDIPHPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDRamilowski2015_Baccin2019DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE	SPIKE_LC:9660793 Cellinker:12884299 HINT:12782716 LRdb:10699158 HPRD:12782716 scConnect:9660793 BioGRID:9660793 scConnect:15761110 BioGRID:12782716 Guide2Pharma:15761110 SIGNOR:12750173 connectomeDB2020:9660793 Baccin2019:12884299 DIP:9625760 SPIKE:9660793 connectomeDB2020:15761110 Baccin2019:12782716 Cellinker:12782716 HPRD:9660793 connectomeDB2020:12884299 DIP:11259614 Cellinker:15761110 Guide2Pharma:9660793 Baccin2019:9660793 Cellinker:9660793 connectomeDB2020:12782716 Baccin2019:15761110 HINT:9660793 ICELLNET:12884299 DIP:9660793
CXL10	P02778	CXCR3	P49682	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerUniProt_LRdbDIPHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDRamilowski2015_Baccin2019DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE	Cellinker:12884299 SPIKE_LC:10233762 HINT:12782716 Baccin2019:12571234 LRdb:10699158 SPIKE_LC:16189514 Baccin2019:10233762 scConnect:9660793 connectomeDB2020:10233762 SPIKE_LC:12571234 scConnect:15761110 HPRD:10233762 Guide2Pharma:15761110 HINT:38012179 SIGNOR:12750173 connectomeDB2020:9660793 Baccin2019:15761110 Baccin2019:12884299 DIP:9625760 SPIKE:12571234 connectomeDB2020:9064356 connectomeDB2020:12571234 HPMR:9064356 SPIKE:10233762 connectomeDB2020:12884299 Cellinker:9064356 Cellinker:10233762 HPRD:12571234 Cellinker:15761110 Guide2Pharma:9660793 Baccin2019:9660793 Cellinker:9660793 Cellinker:12571234 connectomeDB2020:15761110 ICELLNET:12884299 DIP:9660793 Baccin2019:9064356
CXL11	O14625	CXCR3	P49682	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerUniProt_LRdbDIPHPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDDLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE	Cellinker:15273303 Cellinker:12884299 Cellinker:9625760 HINT:12782716 LRdb:10699158 SPIKE:16189514 scConnect:15761110 Guide2Pharma:15761110 SIGNOR:12750173 connectomeDB2020:9625760 DIP:9625760 HPRD:9625760 HPRD:15273303 connectomeDB2020:15273303 HINT:38177682 connectomeDB2020:12884299 DIP:11259614 Cellinker:15761110 connectomeDB2020:15761110 ICELLNET:12884299 SPIKE_LC:16189514

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	37576973 40222457

Sequence, Structure & Domains13

Sequences

Length

368

Mass

40,660

Sequence

MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CXCR3-A; IsoId=P49682-1; Sequence=Displayed; Name=2; Synonyms=CXCR3-B; IsoId=P49682-2; Sequence=VSP_015684; Name=3; Synonyms=CXCR3-alt; IsoId=P49682-3; Sequence=VSP_015685

Alternative Sequence

1..4; MVLE -> MELRKYGPGRLAGTVIGGAAQSKSQTKSDSITKEFLPGLYTAPSSPFPPSQ (in isoform 2); 210..368; VGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL -> GSSSGSGCGCCSCAWAAPTREGSRGSHRLPAGIHPGLRPQRPPTRACEAGIRAPLSPI (in isoform 3)

3D Structural Models

Turn

81..83; 196..199; 282..284; 319..321

Helix

61..80; 88..114; 122..154; 156..162; 169..183; 187..189; 209..244; 249..281; 290..318; 323..334

Beta Strand

190..193; 202..205

3D Structure

Electron microscopy (12)

Domain & Motif Annotations

Compositional Bias

357..368; Low complexity

Region

342..368; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance4

Related Diseases (4)

Hepatic fibrosis/cirrhosis Postoperative inflammation Psoriasis Solid tumour/cancer

Biomarker

Preclinical; Discontinued in Phase 1; Discontinued in Phase 2

Drugs (6)

DDO-3055 IOX1 IOX2 COMPOUND 6EE [PMID: 22364528]ENARODUSTAT VADADUSTAT

Antibody

HPA045942

Supporting Publications3

PMID	Title	Abstract
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
38698420	Single-sEV profiling identifies the TACSTD2 + sEV subpopulation as a factor of tumor susceptibility in the elderly.	No abstract available