Protein detail
NUMB
Protein numb homolog (h-Numb) (Protein S171)
Entry name NUMB | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 13 | Transmembrane count | Protein classification Cancer-related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Protein numb homolog (h-Numb) (Protein S171)
Protein Class (2)
Cancer-related genesPredicted intracellular proteins
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
C14orf41
Gene Description
NUMB endocytic adaptor protein
Chromosome
14
Position
73275107-73458617
Supporting publications (n)
13
EVMP confidence score
0.60
Fluorescence & Localization
Cell SpecificMyonuclei
Function & Pathway
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Cellular Component (11)
- GO:0005737 cytoplasm
- GO:0005769 early endosome
- GO:0005886 plasma membrane
- GO:0005905 clathrin-coated pit
- GO:0005925 focal adhesion
- GO:0010008 endosome membrane
- GO:0016323 basolateral plasma membrane
- GO:0030136 clathrin-coated vesicle
- GO:0031410 cytoplasmic vesicle
- GO:0045177 apical part of cell
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Molecular Function (4)
Biological Process (3)
Reactome (13)
- R-hsa-2122948 activated notch1 transmits signal to the nucleus
- R-hsa-5610780 degradation of gli1 by the proteasome
- R-hsa-9734767 developmental cell lineages
- R-hsa-9734779 developmental cell lineages of the integumentary system
- R-hsa-9725554 differentiation of keratinocytes in interfollicular epidermis in mammalian skin
- R-hsa-5610787 hedgehog off state
- R-hsa-5632684 hedgehog on state
- R-hsa-373760 l1cam interactions
- R-hsa-9675108 nervous system development
- R-hsa-437239 recycling pathway of l1
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Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence38
Enzyme-Mediated Modification (11)
11 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| NUMB | AAK1 | Q2M2I8 | T | 102 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPSIGNORProtMapperphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:18657069ProtMapper:25904845phosphoELM:18657069ProtMapper:18657069 |
| NUMB | CAMK1 | Q14012 | S | 276 | phosphorylation | SIGNOR_ProtMapperPhosphoSiteSIGNORProtMapper | ProtMapper:17022975SIGNOR:17022975 |
| NUMB | PRKCZ | Q05513 | S | 295 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPHPRDKEA | HPRD:18767875KEA:17203073HPRD:17203073 |
| NUMB | PRKCZ | Q05513 | S | 7 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPKEAPhosphoSite | KEA:17203073 |
| NUMB | PRKCZ | Q05513 | S | 284 | phosphorylation | PhosphoSite | |
| NUMB | PRKCZ | Q05513 | S | 265 | phosphorylation | PhosphoSite | |
| NUMB | PRKCI | P41743 | S | 295 | phosphorylation | PhosphoSite | |
| NUMB | PRKCI | P41743 | S | 7 | phosphorylation | PhosphoSite | |
| NUMB | PRKCI | P41743 | S | 276 | phosphorylation | PhosphoSite | |
| NUMB | CAMK4 | Q16566 | S | 276 | phosphorylation | PhosphoSite |
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Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (15)
15 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SIAH1 | Q8IUQ4 | NUMB | P49757 | Yes | Yes | HPRDHINTSIGNORSPIKE_LC | HINT:11752454HPRD:11752454SPIKE_LC:16713569SIGNOR:11752454 | |
| NUMB | P49757 | P53 | P04637 | Yes | Yes | SIGNORBioGRIDIntActDIPWang | BioGRID:23881403DIP:18172499SIGNOR:18492217IntAct:18172499 | |
| KPCI | P41743 | NUMB | P49757 | Yes | Yes | PhosphoSite_norefSIGNORProtMapperWangPhosphoSite_ProtMapper | SIGNOR:17609107 | |
| MSI1H | O43347 | NUMB | P49757 | Yes | Yes | SIGNOR | SIGNOR:20477901 | |
| KPCZ | Q05513 | NUMB | P49757 | Yes | WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperHPRDKEAIntActSPIKE_LCPhosphoSiteHPRD-phosHPRD_KEA | ProtMapper:18767875KEA:17203073SPIKE_LC:17203073HPRD-phos:17203073HPRD:17203073PhosphoSite:21775625IntAct:17203073HPRD-phos:18767875ProtMapper:17203073 |
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Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Lnx1-Jam4-Numb complex | IGSF5LNX1NUMB | P49757Q8TBB1Q9NSI5 | 1:1:1 | Compleat | Compleat:HC1827 | 16832352 |
| NUMB-ITCH | ITCHNUMB | P49757Q96J02 | 0:0 | SPIKE | ||
| NUMB-TP53-MDM2 complex | MDM2NUMBTP53 | P04637P49757Q00987 | 1:1:1 | CompleatCORUM | Compleat:HC2860CORUM:3172 | 18172499 |
| NUMB | P49757 | 4 | PDB | PDB:5njkPDB:5njj |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry [LTQ-FT Ultra] | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
651
Mass
70,804
Sequence
MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL
Alternative Products
Event=Alternative splicing; Named isoforms=9; Name=1; Synonyms=p72; IsoId=P49757-1; Sequence=Displayed; Name=2; Synonyms=p66; IsoId=P49757-2; Sequence=VSP_004349; Name=3; Synonyms=p71; IsoId=P49757-3; Sequence=VSP_004348; Name=4; Synonyms=p65; IsoId=P49757-4; Sequence=VSP_004348, VSP_004349; Name=5; IsoId=P49757-5; Sequence=VSP_047756, VSP_004349; Name=6; IsoId=P49757-6; Sequence=VSP_004348, VSP_047756, VSP_004349; Name=7; IsoId=P49757-7; Sequence=VSP_047756, VSP_053763, VSP_004349; Name=8; IsoId=P49757-8; Sequence=VSP_004348, VSP_047756, VSP_053763, VSP_004349; Name=9; IsoId=P49757-9; Sequence=VSP_053745, VSP_004349
Alternative Sequence
1..254; Missing (in isoform 9); 68..78; Missing (in isoform 3, isoform 4, isoform 6 and isoform 8); 219..316; Missing (in isoform 5, isoform 6, isoform 7 and isoform 8); 317..365; Missing (in isoform 7 and isoform 8); 366..413; Missing (in isoform 2, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9)
3D Structural Models
Turn
72..74; 100..102; 134..137
Helix
28..33; 55..71; 77..79; 111..113; 151..168
Beta Strand
38..48; 50..53; 84..90; 92..99; 105..110; 114..119; 126..133; 138..149
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
235..252; Low complexity; 436..449; Basic and acidic residues; 453..466; Low complexity; 630..644; Polar residues
Domain (FT)
33..193; PID
Region
228..255; Disordered; 419..483; Disordered; 623..651; Disordered
Clinical Relevance
Disease Involvement
Cancer-related genes
Interaction Protein (11)
ENSG00000006125ENSG00000072201ENSG00000085832ENSG00000108953ENSG00000122705ENSG00000135679ENSG00000141510ENSG00000146648ENSG00000164924ENSG00000166913ENSG00000170027
Interaction Count
11
Interaction Dataset (2)
biogrid_opencellintact_biogrid
Supporting Publications13
| PMID | Title | Related sentences |
|---|---|---|
| 28590090 | Motile hepatocellular carcinoma cells preferentially secret sugar metabolism regulatory proteins via exosomes. | No related sentences available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No related sentences available |
| 29148239 | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | No related sentences available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 30950185 | Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer. | No related sentences available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No related sentences available |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No related sentences available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No related sentences available |
| 36398564 | Differential ultracentrifugation enables deep plasma proteomics through enrichment of extracellular vesicles. | No related sentences available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No related sentences available |
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