Protein detail
FHIT
Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Adenosine 5'-monophosphoramidase FHIT) (EC 3.9.1.-) (Adenylylsulfatase) (EC 3.6.2.1) (Adenylylsulfate-ammonia adenylyltransferase) (EC 2.7.7.51) (Diadenosine 5',5'''-P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (Fragile histidine triad protein)
Entry name FHIT | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Cancer-related genesDisease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Adenosine 5'-monophosphoramidase FHIT) (EC 3.9.1.-) (Adenylylsulfatase) (EC 3.6.2.1) (Adenylylsulfate-ammonia adenylyltransferase) (EC 2.7.7.51) (Diadenosine 5',5'''-P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (Fragile histidine triad protein)
Protein Class (7)
Cancer-related genesDisease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (8)
- Human disease related genes:Cancers:Cancers of the lung and pleura
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins:Hydrolases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
AP3AaseFRA3B
Gene Description
Fragile histidine triad diadenosine triphosphatase
Chromosome
3
Position
59747277-61251459
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization4
Cell SpecificEarly spermatidsBlood Cell SpecificneutrophilBlood Lineage Specificdendritic cells
Function & Pathway6
Protein Function (8)
- Human disease related genes:Cancers:Cancers of the lung and pleura
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins:Hydrolases
- Disease related genes
Cellular Component (6)
Molecular Function (8)
- GO:0000166 nucleotide binding
- GO:0005515 protein binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0042802 identical protein binding
- GO:0043530 adenosine 5'-monophosphoramidase activity
- GO:0047352 adenylylsulfate-ammonia adenylyltransferase activity
- GO:0047627 adenylylsulfatase activity
- GO:0047710 bis(5'-adenosyl)-triphosphatase activity
Biological Process (3)
KEGG (4)
Mediation Categories
Clinical-translation mediation
Relations & Evidence14
Enzyme-Mediated Modification (3)
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| FHIT | SRC | P12931 | Y | 114 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDRLIMS-P_ProtMapperdbPTMKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | dbPTM:15007172KEA:15835917ProtMapper:15007172ProtMapper:19086848HPRD:15835917ProtMapper:15835917ProtMapper:23947369KEA:2507541SIGNOR:15835917ProtMapper:17142325ProtMapper:29296239 |
| FHIT | KNG1 | P01042 | Y | 114 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:23947369 |
| FHIT | CSK | P41240 | Y | 114 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:19286306 |
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FHIT | P49789 | CTNB1 | P35222 | Yes | No | Yes | DIPSIGNORIntAct | SIGNOR:18077326DIP:18077326IntAct:18077326 |
| SRC | P12931 | FHIT | P49789 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAHPRDPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperHPRD-phos | dbPTM:15007172KEA:15835917SIGNOR:15835917HPRD-phos:15835917ProtMapper:15007172ProtMapper:19086848HPRD:15835917ProtMapper:15835917ProtMapper:19286306ProtMapper:23947369PhosphoSite:15835917PhosphoSite:19004824KEA:2507541PhosphoSite:15007172ProtMapper:23993961ProtMapper:17142325ProtMapper:29296239 |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ALDH1A1ALDH2FHITHSPD1HSPE1IMMT | P00352P05091P10809P49789P61604Q16891 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7116 | ||
| ALDH2FHITHSPD1HSPE1TSC1 | P05091P10809P49789P61604Q92574 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8760 | ||
| FHIT | P49789 | 4 | PDB | PDB:7p8p |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry [MALDI TOF]Mass spectrometryMass spectrometry [LTQ-FT Ultra]R Sequencing | 1 | 32384937 |
Sequence, Structure & Domains9
Sequences
Length
147
Mass
16,858
Sequence
MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRNDSIYEELQKHDKEDFPASWRSEEEMAAEAAALRVYFQ
3D Structural Models
Turn
120..123
Helix
12..14; 47..49; 52..72; 86..88; 112..119; 132..144
Beta Strand
3..5; 8..10; 15..18; 20..26; 36..42; 76..82; 92..94; 97..102
3D Structure
X-ray crystallography (9)
Domain & Motif Annotations
Motif
94..98; Histidine triad motif
Domain (FT)
2..109; HIT
Clinical Relevance8
Disease Involvement (2)
Cancer-related genesTumor suppressor
Related Diseases
Biomarker
Approved
Interaction Protein
ENSG00000168036
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 32301581 | Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. | Extracellular vesicles (EVs) from human Alzheimer's disease (AD) biospecimens contain amyloid beta (Aβ) peptide and tau. |
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |