Protein detail
RGS3
Regulator of G-protein signaling 3 (RGP3) (RGS3)
Entry name RGS3 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Regulator of G-protein signaling 3 (RGP3) (RGS3)
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificintestineCell SpecificColonocytesSingle-Nuclei Brain Specificupper-layer intratelencephalicBlood Cell SpecificNK-cellBlood Lineage SpecificNK-cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
4 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometryAntibody arrayWestern blotting | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
1,198
Mass
132,336
Sequence
MPVIPALWEVEMGRSQGQEIETILANRSHSDSTPLPNFLSGSHRPECCTCRLLTASGAQDSLPFGRRLYSGPWRSCEEVCHVSVLSVLSTSCGLSLSLPIFPGWMEWLSPDIALPRRDEWTQTSPARKRITHAKVQGAGQLRLSIDAQDRVLLLHIIEGKGLISKQPGTCDPYVKISLIPEDSRLRHQKTQTVPDCRDPAFHEHFFFPVQEEDDQKRLLVTVWNRASQSRQSGLIGCMSFGVKSLLTPDKEISGWYYLLGEHLGRTKHLKVARRRLRPLRDPLLRMPGGGDTENGKKLKITIPRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWRMVPQVKPGPDGGVLRRASCKSTHDLQSPPNKREKNCTHGVQARPEQRHSCHLVCDSSDGLLLGGWERYTEVAKRGGQHTLPALSRATAPTDPNYIILAPLNPGSQLLRPVYQEDTIPEESGSPSKGKSYTGLGKKSRLMKTVQTMKGHGNYQNCPVVRPHATHSSYGTYVTLAPKVLVFPVFVQPLDLCNPARTLLLSEELLLYEGRNKAAEVTLFAYSDLLLFTKEDEPGRCDVLRNPLYLQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLAASPPDSKMFETEADEKREMALEEGKGPGAEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDPLLTKDLPAIQESPTRDLPPCQDLPPSQVSLPAKALTEDTMSSGDLLAATGDPPAAPRPAFVIPEVRLDSTYSQKAGAEQGCSGDEEDAEEAEEVEEGEEGEEDEDEDTSDDNYGERSEAKRSSMIETGQGAEGGLSLRVQNSLRRRTHSEGSLLQEPRGPCFASDTTLHCSDGEGAASTWGMPSPSTLKKELGRNGGSMHHLSLFFTGHRKMSGADTVGDDDEASRKRKSKNLAKDMKNKLGIFRRRNESPGAPPAGKADKMMKSFKPTSEEALKWGESLEKLLVHKYGLAVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMASKAKKIFAEYIAIQACKEVNLDSYTREHTKDNLQSVTRGCFDLAQKRIFGLMEKDSYPRFLRSDLYLDLINQKKMSPPL
Alternative Products
Event=Alternative splicing; Named isoforms=9; Name=3; IsoId=P49796-3; Sequence=Displayed; Name=1; IsoId=P49796-1; Sequence=VSP_013958; Name=2; Synonyms=RGS3T; IsoId=P49796-2; Sequence=VSP_005662; Name=4; Synonyms=1; IsoId=P49796-4; Sequence=VSP_013959, VSP_013963; Name=5; IsoId=P49796-5; Sequence=VSP_013961, VSP_013962, VSP_013964, VSP_013965; Name=6; Synonyms=C2PA-RGS3; IsoId=P49796-6; Sequence=VSP_013960; Name=7; IsoId=P49796-7; Sequence=VSP_047029; Name=8; Synonyms=RGS3S; IsoId=P49796-8; Sequence=VSP_047029, VSP_053533; Name=9; IsoId=P49796-9; Sequence=VSP_013959, VSP_013963, VSP_054690
Alternative Sequence
1..1027; MPVIPALWEVEMGRSQGQEIETILANRSHSDSTPLPNFLSGSHRPECCTCRLLTASGAQDSLPFGRRLYSGPWRSCEEVCHVSVLSVLSTSCGLSLSLPIFPGWMEWLSPDIALPRRDEWTQTSPARKRITHAKVQGAGQLRLSIDAQDRVLLLHIIEGKGLISKQPGTCDPYVKISLIPEDSRLRHQKTQTVPDCRDPAFHEHFFFPVQEEDDQKRLLVTVWNRASQSRQSGLIGCMSFGVKSLLTPDKEISGWYYLLGEHLGRTKHLKVARRRLRPLRDPLLRMPGGGDTENGKKLKITIPRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWRMVPQVKPGPDGGVLRRASCKSTHDLQSPPNKREKNCTHGVQARPEQRHSCHLVCDSSDGLLLGGWERYTEVAKRGGQHTLPALSRATAPTDPNYIILAPLNPGSQLLRPVYQEDTIPEESGSPSKGKSYTGLGKKSRLMKTVQTMKGHGNYQNCPVVRPHATHSSYGTYVTLAPKVLVFPVFVQPLDLCNPARTLLLSEELLLYEGRNKAAEVTLFAYSDLLLFTKEDEPGRCDVLRNPLYLQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLAASPPDSKMFETEADEKREMALEEGKGPGAEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDPLLTKDLPAIQESPTRDLPPCQDLPPSQVSLPAKALTEDTMSSGDLLAATGDPPAAPRPAFVIPEVRLDSTYSQKAGAEQGCSGDEEDAEEAEEVEEGEEGEEDEDEDTSDDNYGERSEAKRSSMIETGQGAEGGLSLRVQNSLRRRTHSEGSLLQEPRGPCFASDTTLHCSDGEGAASTWGMPSPSTLKKELGRNGGSMHHLSLFFTGHRKMSGADTVGDDDEASRKRKSKNL -> MVTRRPVTNSWDWLPAGAAPEAVPCRHMPLSRLPLRVGQKEFFFPLPLLVPPISWLLLSESQPRLVPGSPVIRPGFQRACVAAACTVAARCPGRGVGDRSQSGASYRPICGPKVGGPTEMLRGMYLTRNGNLQRRHTMKE (in isoform 7 and isoform 8); 1..992; Missing (in isoform 2); 1..679; Missing (in isoform 1); 1..281; Missing (in isoform 4 and isoform 9); 1..112; Missing (in isoform 5); 1..104; Missing (in isoform 6); 113..138; ALPRRDEWTQTSPARKRITHAKVQGA -> MERSLHRVSLGSRRAHPDLSFYLTTF (in isoform 5); 282..299; PLLRMPGGGDTENGKKLK -> MNRFNGLCKVCSERRYRQ (in isoform 4 and isoform 9); 679..1004; Missing (in isoform 9); 680..714; MFETEADEKREMALEEGKGPGAEDSPPSKEPSPGQ -> KLHPFGSLQQEMGPVNSTNATQDRSFTSPGQTLIG (in isoform 5); 715..1198; Missing (in isoform 5); 1198; L -> LDYKDDDDK (in isoform 8)
3D Structural Models
Turn
1157..1160; 1187..1189
Helix
211..213; 229..231; 242..245; 263..265; 329..333; 354..362; 1066..1070; 1074..1078; 1081..1093; 1097..1109; 1115..1129; 1142..1150; 1161..1173; 1175..1181; 1183..1186
Beta Strand
140..161; 166..168; 172..180; 200..208; 216..224; 233..241; 252..257; 299..303; 310..314; 316..318; 320..324; 340..344; 365..374
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
679..697; Basic and acidic residues; 739..751; Polar residues; 753..773; Pro residues; 877..906; Acidic residues; 907..917; Basic and acidic residues
Domain (FT)
137..256; C2; 299..376; PDZ; 1073..1198; RGS
Region
669..933; Disordered; 1007..1026; Disordered; 1032..1056; Disordered