Protein detail
AGTR2
Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2 receptor)
Protein symbol AGTR2 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 7 | Protein classification |
Basic Information
Protein Names
Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2 receptor)
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
46..70; Helical; Name=1; 81..104; Helical; Name=2; 115..140; Helical; Name=3; 160..181; Helical; Name=4; 207..232; Helical; Name=5; 258..281; Helical; Name=6; 295..320; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecifictestisCell SpecificDifferentiating spermatogoniaSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
M53 Pid integrin3 pathway
Mediation Categories
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
63 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| angiotensin | receptor | HGNC | No | Yes | No | Yes | No |
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| AGTR2 | P50052 | GNAQ | P50148 | Yes | Yes | No | SIGNOR | SIGNOR:11313903 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | ELISA | 1 | 40784529 |
Sequence, Structure & Domains
Sequences
Length
363
Mass
41,184
Sequence
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
3D Structural Models
Turn
39..42; 106..108; 188..190; 319..321
Helix
43..45; 46..71; 79..94; 97..105; 113..147; 149..151; 159..174; 176..181; 201..203; 205..219; 221..240; 246..283; 290..318; 322..333; 335..339
Beta Strand
153..155; 182..186; 193..197
3D Structure
X-ray crystallography (7)
Domain & Motif Annotations
Domain (CC)
Helix VIII may act as a gatekeeper for either suppression or activation of the receptor, depending on post-translational modifications and interactions with various receptor partners (PubMed:28379944). Helix VIII is found in a non-canonical position, stabilizing the active-like state, but at the same time preventing the recruitment of G-proteins or beta-arrestins (PubMed:28379944). Upon switching to a membrane-bound conformation, helix VIII can support the recruitment of G proteins and beta-arrestins (PubMed:28379944).
Region
324..333; Helix VIII
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Related Diseases
Biomarker
Approved; Phase 2
Drugs
Interaction Protein
ENSG00000100234
Interaction Count
1
Interaction Dataset
intact_biogrid