Protein detail
GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q)
Entry name GNAQ | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Predicted intracellular proteins
- Cancer-related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
G-ALPHA-qGAQ
Gene Description
G protein subunit alpha q
Chromosome
9
Position
77716097-78031811
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificCardiomyocytes
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Predicted intracellular proteins
- Cancer-related genes
Cellular Component
Molecular Function
- GO:0001664 G protein-coupled receptor binding
- GO:0003924 GTPase activity
- GO:0003925 G protein activity
- GO:0005096 GTPase activator activity
- GO:0005515 protein binding
- GO:0005525 GTP binding
- GO:0030234 enzyme regulator activity
- GO:0031683 G-protein beta/gamma-subunit complex binding
- GO:0046872 metal ion binding
Biological Process
KEGG
- hsa04015 Rap1 signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04071 Sphingolipid signaling pathway
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04082 Neuroactive ligand signaling
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04270 Vascular smooth muscle contraction
- KEGG:hsa04371 Apelin signaling pathway
- KEGG:hsa04540 Gap junction
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04713 Circadian entrainment
- KEGG:hsa04720 Long-term potentiation
- KEGG:hsa04723 Retrograde endocannabinoid signaling
- KEGG:hsa04724 Glutamatergic synapse
- KEGG:hsa04725 Cholinergic synapse
- KEGG:hsa04726 Serotonergic synapse
- KEGG:hsa04728 Dopaminergic synapse
- KEGG:hsa04730 Long-term depression
- KEGG:hsa04750 Inflammatory mediator regulation of TRP channels
- KEGG:hsa04911 Insulin secretion
- KEGG:hsa04912 GnRH signaling pathway
- KEGG:hsa04915 Estrogen signaling pathway
- KEGG:hsa04916 Melanogenesis
- KEGG:hsa04918 Thyroid hormone synthesis
- KEGG:hsa04921 Oxytocin signaling pathway
- KEGG:hsa04922 Glucagon signaling pathway
- KEGG:hsa04924 Renin secretion
- KEGG:hsa04925 Aldosterone synthesis and secretion
- KEGG:hsa04927 Cortisol synthesis and secretion
- KEGG:hsa04928 Parathyroid hormone synthesis, secretion and action
- KEGG:hsa04929 GnRH secretion
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa04935 Growth hormone synthesis, secretion and action
- KEGG:hsa04961 Endocrine and other factor-regulated calcium reabsorption
- KEGG:hsa04970 Salivary secretion
- KEGG:hsa04971 Gastric acid secretion
- KEGG:hsa04972 Pancreatic secretion
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05016 Huntington disease
- KEGG:hsa05017 Spinocerebellar ataxia
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05135 Yersinia infection
- KEGG:hsa05142 Chagas disease
- KEGG:hsa05143 African trypanosomiasis
- KEGG:hsa05146 Amoebiasis
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05170 Human immunodeficiency virus 1 infection
- KEGG:hsa05200 Pathways in cancer
Reactome
- R-hsa-399997 acetylcholine regulates insulin secretion
- R-hsa-418592 adp signalling through p2y purinoceptor 1
- R-hsa-9855142 cellular responses to mechanical stimuli
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-6814122 cooperation of pdcl phlp1 and tric cct in g protein beta folding
- R-hsa-434316 fatty acids bound to gpr40 ffar1 regulate insulin secretion
- R-hsa-400451 free fatty acids regulate insulin secretion
- R-hsa-418594 g alpha i signalling events
- R-hsa-416476 g alpha q signalling events
- R-hsa-202040 g protein activation
- R-hsa-112040 g protein mediated events
- R-hsa-109582 hemostasis
- R-hsa-9856530 high laminar flow shear stress activates signaling by piezo1 and pecam1 cdh5 kdr in endothelial cells
- R-hsa-163685 integration of energy metabolism
- R-hsa-111885 opioid signalling
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-391251 protein folding
- R-hsa-422356 regulation of insulin secretion
- R-hsa-372790 signaling by gpcr
- R-hsa-392518 signal amplification
- R-hsa-456926 thrombin signalling through proteinase activated receptors pars
- R-hsa-428930 thromboxane signalling through tp receptor
- R-hsa-9860927 turbulent oscillatory disturbed flow shear stress activates signaling by piezo1 and integrins in endothelial cells
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GNAQ | CDK5 | Q00535 | S | 53 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
97 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GNAQ | P50148 | PLCE1 | Q9P212 | Yes | Yes | No | SIGNOR | SIGNOR:17251915 |
| EDNRA | P25101 | GNAQ | P50148 | Yes | Yes | No | WangSIGNOR | SIGNOR:15475516SIGNOR:31160049 |
| PAR1 | P25116 | GNAQ | P50148 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| GNAQ | P50148 | TARA | Q9H2D6 | Yes | Yes | No | SIGNOR | SIGNOR:17606614 |
| AA2BR | P29275 | GNAQ | P50148 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| PI2R | P43119 | GNAQ | P50148 | Yes | Yes | No | HPRDHINTSIGNOR | SIGNOR:31160049HINT:11443126HPRD:11443126HPRD:10446129HINT:10446129 |
| MTLR | O43193 | GNAQ | P50148 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| GNAQ | P50148 | ARHGC | Q9NZN5 | Yes | Yes | No | KEGG-MEDICUSSIGNOR | SIGNOR:12024019 |
| TA2R | P21731 | GNAQ | P50148 | Yes | Yes | No | SIGNORHPRDHINTBioGRIDLit-BM-17 | BioGRID:12726995Lit-BM-17:15134434SIGNOR:31160049HPRD:9152406Lit-BM-17:20590159Lit-BM-17:12399457HPRD:12193606HINT:15782186HINT:20590159BioGRID:23962128Lit-BM-17:21940795Lit-BM-17:23962128Lit-BM-17:12726995Lit-BM-17:15782186HINT:12399457 |
| V1BR | P47901 | GNAQ | P50148 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DUSP1GNAQMAP2K3MAP2K6MAP3K5MAPK12MAPK14MAPK3PLCB2TAOK2 | P27361P28562P46734P50148P52564P53778Q00722Q16539Q99683Q9UL54 | 1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8505 | ||
| GNAQPLCB3 | P50148Q01970 | 1:1 | PDB | PDB:8uqn |
Isolation & Detection Technology
0 records.
Sequence, Structure & Domains
Sequences
Length
359
Mass
42,142
Sequence
MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAYLPTQQDVLRVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
3D Structural Models
Turn
118..120; 147..150; 239..243; 283..285; 355..357
Helix
25..36; 52..62; 69..96; 104..115; 126..137; 139..146; 157..162; 164..168; 176..181; 213..215; 217..220; 232..234; 247..252; 255..259; 262..264; 276..282; 288..291; 293..295; 304..314; 336..354
Beta Strand
41..45; 48..50; 169..171; 190..195; 197..205; 224..231; 268..274; 299..301; 319..321; 324..328
3D Structure
Electron microscopy (28)
Domain & Motif Annotations
Domain (FT)
38..359; G-alpha
Region
41..54; G1 motif; 178..186; G2 motif; 201..210; G3 motif; 270..277; G4 motif; 329..334; G5 motif
Protein Families
- G-alpha family
- G(q) subfamily
Sequence Similarities
Belongs to the G-alpha family. G(q) subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variant
Interaction Protein
ENSG00000078369
Interaction Count
1
Interaction Dataset
biogrid_opencell