Protein detail
VASP
Vasodilator-stimulated phosphoprotein (VASP)
Entry name VASP | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 9 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Vasodilator-stimulated phosphoprotein (VASP)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
Vasodilator stimulated phosphoprotein
Chromosome
19
Position
45506579-45526989
Supporting publications (n)
9
EVMP confidence score
0.63
Fluorescence & Localization5
Cell SpecificLymphatic endothelial cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificNK-cellBlood Lineage SpecificNK-cells
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (10)
Molecular Function (4)
Biological Process (3)
KEGG (8)
Reactome (8)
- R-hsa-1280218 adaptive immune system
- R-hsa-1500931 cell cell communication
- R-hsa-446353 cell extracellular matrix interactions
- R-hsa-446728 cell junction organization
- R-hsa-202433 generation of second messenger molecules
- R-hsa-9675108 nervous system development
- R-hsa-376176 signaling by robo receptors
- R-hsa-202403 tcr signaling
Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence99
Enzyme-Mediated Modification (69)
69 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| VASP | PRKAA2 | P54646 | T | 278 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:17082196ProtMapper:17082196 |
| VASP | PRKAA2 | P54646 | S | 322 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:21945940SIGNOR:21945940 |
| VASP | PRKG1 | Q13976 | S | 157 | phosphorylation | BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:10851246ProtMapper:15212693HPRD:12576312KEA:10922374HPRD:20058876KEA:8182057KEA:94237860ProtMapper:14679200KEA:9685341SIGNOR:14679200KEA:14679200KEA:7925440KEA:12576312 |
| VASP | PRKG1 | Q13976 | T | 278 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:94237860ProtMapper:12576312SIGNOR:12576312KEA:8182057 |
| VASP | PRKG1 | Q13976 | S | 239 | phosphorylation | BEL-Large-Corpus_ProtMapperSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDRLIMS-P_ProtMapperKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:10851246ProtMapper:21702043ProtMapper:15212693KEA:12576312ProtMapper:23867907HPRD:12576312KEA:10922374KEA:8182057KEA:94237860ProtMapper:14679200HPRD:17287340SIGNOR:14679200KEA:14679200ProtMapper:20483741HPRD:20166139 |
| VASP | RPS6KA1 | Q15418 | T | 278 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:24097826ProtMapper:21423205SIGNOR:21423205 |
| VASP | PRKACA | P17612 | T | 278 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:94237860ProtMapper:8182057SIGNOR:8182057KEA:8182057 |
| VASP | PRKACA | P17612 | S | 239 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:12576312KEA:10851246KEA:12576312HPRD:12576312KEA:10922374KEA:8182057KEA:94237860ProtMapper:12576312HPRD:17287340KEA:14679200HPRD:20166139 |
| VASP | PRKACA | P17612 | S | 157 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:12576312KEA:10851246ProtMapper:16197368SIGNOR:16197368HPRD:12576312KEA:10922374HPRD:20058876KEA:8182057KEA:94237860ProtMapper:12576312KEA:9685341KEA:14679200KEA:7925440KEA:12576312 |
| VASP | PRKAB2 | O43741 | S | 322 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:21945940SIGNOR:21945940 |
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Ligand-Receptor Signaling (16)
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| actin_regulation_adhesome | intracellular_intercellular_related | Adhesome | Yes | No | Yes | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | Yes | No | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | Yes | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | No | No |
| secreted | secreted | connectomeDB2020 | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
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Regulatory Interaction Network (11)
11 records.
Page 1 of 2Next
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometryMass spectrometry [LTQ-FT Ultra]Western blotting | 1 | 32384937 |
Sequence, Structure & Domains16
Sequences
Length
380
Mass
39,830
Sequence
MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVVINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEGGGPPPPPALPTWSVPNGPSPEEVEQQKRQQPGPSEHIERRVSNAGGPPAPPAGGPPPPPGPPPPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPAAQGPGGGGAGAPGLAAAIAGAKLRKVSKQEEASGGPTAPKAESGRSGGGGLMEEMNAMLARRRKATQVGEKTPKDESANQEEPEARVPAQSESVRRPWEKNSTTLPRMKSSSSVTTSETQPCTPSSSDYSDLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKRGSP
3D Structural Models
Turn
18..20; 42..45
Helix
96..114; 226..231; 341..376
Beta Strand
5..12; 14..16; 25..27; 34..41; 46..55; 60..66; 79..86; 88..95
3D Structure
Electron microscopy (3); NMR spectroscopy (1); X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
162..192; Pro residues; 224..233; Low complexity; 312..342; Polar residues
Repeat
344..358; 1; 359..373; 2
Motif
234..237; KLKR
Coiled Coil
337..373
Domain (CC)
The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.; DOMAIN: The WH1 domain mediates interaction with XIRP1.
Domain (FT)
2..113; WH1
Region
111..343; Disordered; 225..377; EVH2; 225..245; EVH2 block A; 259..278; EVH2 block B; 343..377; EVH2 block C; 344..373; 2 X 15 AA tandem repeats of L-[EQ]-[KR]-[MV]-K-[EQ]-E-[IL]-[IL]-E-[AEV]-[FV]-[KRV]-[KQ]-E
Protein Families
Ena/VASP family
Sequence Similarities
Belongs to the Ena/VASP family.
Clinical Relevance5
Drugs
Interaction Protein (11)
ENSG00000075624ENSG00000100505ENSG00000108518ENSG00000109971ENSG00000138443ENSG00000154380ENSG00000159840ENSG00000168334ENSG00000184009ENSG00000196405ENSG00000213066
Interaction Count
11
Interaction Dataset (3)
biogrid_opencellintact_biogridintact_biogrid_opencell
Supporting Publications9
| PMID | Title | Abstract |
|---|---|---|
| 25776846 | Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens. | No abstract available |
| 28211531 | Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer. | No abstract available |
| 28240915 | Quantitative Proteomic Analysis of Serum Exosomes from Patients with Locally Advanced Pancreatic Cancer Undergoing Chemoradiotherapy. | No abstract available |
| 29441425 | Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins. | No abstract available |
| 31414377 | Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics. | No abstract available |
| 32331267 | Mass Spectrometry-Based Proteomic Characterization of Cutaneous Melanoma Ectosomes Reveals the Presence of Cancer-Related Molecules. | No abstract available |
| 33017416 | Proteomic analysis of plasma exosomes from Cystic Echinococcosis patients provides in vivo support for distinct immune response profiles in active vs inactive infection and suggests potential biomarkers. | No abstract available |
| 33169421 | A novel method of high-purity extracellular vesicle enrichment from microliter-scale human serum for proteomic analysis. | No abstract available |
| 34202855 | Proteomic Profiling of Ectosomes Derived from Paired Urothelial Bladder Cancer and Normal Cells Reveals the Presence of Biologically-Relevant Molecules. | No abstract available |