EV MemProt Atlas

Basic Information

Protein Names

Vasodilator-stimulated phosphoprotein (VASP)

Protein Class

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000125753

Entrez Gene Symbol

VASP

Gene Description

Vasodilator stimulated phosphoprotein

Chromosome

19

Position

45506579-45526989

Frequency

9

EVMP Score

0.63

Fluorescence & Localization

Cell SpecificLymphatic endothelial cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificNK-cellBlood Lineage SpecificNK-cells

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

69 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
VASP	PRKAG2	Q9UGJ0	S	322	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:21945940 SIGNOR:21945940
VASP	PRKD1	Q15139	S	157	phosphorylation	Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:28051168 ProtMapper:23846685
VASP	PRKD1	Q15139	S	322	phosphorylation	Sparser_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:23846685
VASP	PRKD1	Q15139	S	324	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:28051168
VASP	PRKD2	Q9BZL6	S	239	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
VASP	PRKD2	Q9BZL6	S	157	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
VASP	PRKD2	Q9BZL6	S	322	phosphorylation	Sparser_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:26336132
VASP	PRKCA	P17252	S	157	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:14706852
VASP	ALK	Q9UM73	Y	39	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
VASP	PRKX	P51817	S	157	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP

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Ligand-Receptor Signaling

16 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	OmniPath	No	No	Yes	No	No
intracellular	intracellular	LOCATE	No	No	Yes	No	No
intracellular	intracellular	ComPPI	No	No	Yes	No	No
intracellular	intracellular	GO_Intercell	No	No	Yes	No	No
intracellular	intracellular	UniProt_location	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	Yes	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	Yes	No	No
tight_junction	tight_junction	GO_Intercell	Yes	Yes	Yes	No	No
tight_junction	tight_junction	OmniPath	Yes	Yes	Yes	No	No

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Regulatory Interaction Network

11 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ALK	Q9UM73	VASP	P50552	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:18845790

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Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ACAT2 AMOT CPNE3 VASP	O75131 P50552 Q4VCS5 Q9BWD1	0:0:0:0	Havugimana2012	Havugimana2012:C_277
	VASP	P50552	4	PDB	PDB:8yvl

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometryMass spectrometry [LTQ-FT Ultra]Western blotting	1	32384937

Sequence, Structure & Domains

Sequences

Length

380

Mass

39,830

Sequence

MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVVINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEGGGPPPPPALPTWSVPNGPSPEEVEQQKRQQPGPSEHIERRVSNAGGPPAPPAGGPPPPPGPPPPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPAAQGPGGGGAGAPGLAAAIAGAKLRKVSKQEEASGGPTAPKAESGRSGGGGLMEEMNAMLARRRKATQVGEKTPKDESANQEEPEARVPAQSESVRRPWEKNSTTLPRMKSSSSVTTSETQPCTPSSSDYSDLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKRGSP

3D Structural Models

Turn

18..20; 42..45

Helix

96..114; 226..231; 341..376

Beta Strand

5..12; 14..16; 25..27; 34..41; 46..55; 60..66; 79..86; 88..95

3D Structure

Electron microscopy (3); NMR spectroscopy (1); X-ray crystallography (5)

Domain & Motif Annotations

Compositional Bias

162..192; Pro residues; 224..233; Low complexity; 312..342; Polar residues

Repeat

344..358; 1; 359..373; 2

Motif

234..237; KLKR

Coiled Coil

337..373

Domain (CC)

The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization.; DOMAIN: The WH1 domain mediates interaction with XIRP1.

Domain (FT)

2..113; WH1

Region

111..343; Disordered; 225..377; EVH2; 225..245; EVH2 block A; 259..278; EVH2 block B; 343..377; EVH2 block C; 344..373; 2 X 15 AA tandem repeats of L-[EQ]-[KR]-[MV]-K-[EQ]-E-[IL]-[IL]-E-[AEV]-[FV]-[KRV]-[KQ]-E

Protein Families

Ena/VASP family

Sequence Similarities

Belongs to the Ena/VASP family.

Clinical Relevance

Drugs

HYDROCHLOROTHIAZIDE

Antibody

CAB004612 HPA005724

Interaction Protein

ENSG00000075624ENSG00000100505ENSG00000108518ENSG00000109971ENSG00000138443ENSG00000154380ENSG00000159840ENSG00000168334ENSG00000184009ENSG00000196405ENSG00000213066

Interaction Count

11

Interaction Dataset

biogrid_opencellintact_biogridintact_biogrid_opencell

Protein symbol VASP	UniProt ID P50552	EVMP score 0.63
Frequency 9	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins