Protein detail

MAP2

Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M)

Entry name MAP2	UniProt ID P50579	EVMP confidence score 0.60
Supporting publications (n) 11	Transmembrane count	Protein classification EnzymesEssential proteinsPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M)

Protein Class (4)

EnzymesEssential proteinsPlasma proteinsPredicted intracellular proteins

Protein Function (4)

Peptidases:Metallopeptidases
Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Ensembl

ENSG00000111142

Entrez Gene Symbol

METAP2

Gene Synonym (3)

MAP2MNPEPp67

Gene Description

Methionyl aminopeptidase 2

Chromosome

Position

95473520-95515839

Supporting publications (n)

EVMP confidence score

0.60

Fluorescence & Localization2

Cell SpecificChoroid plexus epithelial cells

Function & Pathway7

Protein Function (4)

Peptidases:Metallopeptidases
Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Cellular Component (3)

Molecular Function (7)

Biological Process (3)

Reactome (3)

Canonical Pathways (3)

M5880 Naba ecm affiliated
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories (2)

Clinical-translation mediationMetabolism mediation

Relations & Evidence13

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Protein Complex Composition (6)

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CDC123 EIF2S1 EIF2S2 EIF2S3 METAP2 PRMT7	O75794 P05198 P20042 P41091 P50579 Q9NVM4	0:0:0:0:0:0	hu.MAP2
CDC123 EIF2S2 EIF2S3 METAP2 PLIN5 PYM1	O75794 P20042 P41091 P50579 Q00G26 Q9BRP8	0:0:0:0:0:0	hu.MAP2
METAP2 NAA10 NAA15 RPL19 RPL23A RPL26 RPL28 RPL35 RPL38 RPL4 RPL6	P36578 P41227 P42766 P46779 P50579 P61254 P62750 P63173 P84098 Q02878 Q9BXJ9	1:1:1:1:1:1:1:1:1:1:1	PDB	PDB:9fpz
METAP2 RPL19 RPL23A RPL26 RPL35 RPL38	P42766 P50579 P61254 P62750 P63173 P84098	1:1:1:1:1:1	PDB	PDB:8ony
METAP2	P50579	2	PDB	PDB:8oxg
METAP2 PLIN5	P50579 Q00G26	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27894104

Sequence, Structure & Domains13

Sequences

Length

478

Mass

52,892

Sequence

MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P50579-1; Sequence=Displayed; Name=2; IsoId=P50579-2; Sequence=VSP_055467, VSP_055468; Name=3; IsoId=P50579-3; Sequence=VSP_057353

Alternative Sequence

50; Missing (in isoform 2); 87..109; DGDGDGDGATGKKKKKKKKKRGP -> A (in isoform 2); 109..132; PKVQTDPPSVPICDLYPNGVFPKG -> R (in isoform 3)

3D Structural Models

Turn

410..412; 422..424

Helix

120..123; 147..151; 153..160; 163..186; 193..208; 212..214; 271..273; 274..290; 297..309; 397..409; 417..421; 429..437

Beta Strand

124..127; 133..135; 141..143; 215..225; 228..231; 248..256; 259..267; 312..315; 318..321; 330..334; 337..339; 346..349; 360..370; 382..385; 440..444; 455..464; 469..471

3D Structure

Electron microscopy (2); X-ray crystallography (38)

Domain & Motif Annotations

Compositional Bias

36..46; Basic residues; 55..79; Basic and acidic residues; 80..92; Acidic residues; 97..109; Basic residues

Region

1..122; Disordered

Protein Families (2)

Peptidase M24A family
Methionine aminopeptidase eukaryotic type 2 subfamily

Sequence Similarities

Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.

Clinical Relevance8

Related Diseases (4)

Diabetes mellitus Obesity Solid tumour/cancer Type 2 diabetes mellitus

Biomarker

Phase 1; Phase 3; Phase 2

Drug Targets

Clinical trial target

Drugs (8)

D-METHIONINE FUMAGILLIN-DERIVED POLYMER CONJUGATE XMT-1107 M8891 ACLIMOSTAT PPI-2458 EVEXOMOSTAT BELORANIB TOSEDOSTAT

Antibody (2)

CAB013025 HPA019095

Interaction Protein (2)

ENSG00000124214ENSG00000166226

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications11

PMID	Title	Abstract
26826536	[Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles].	No abstract available
31805958	Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.	No abstract available
32560723	T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.	No abstract available
34064677	Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells.	No abstract available
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No abstract available
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
37926756	Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available

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