Protein detail

TUB

Tubby protein homolog

Entry name TUB	UniProt ID P50607	EVMP confidence score 0.38
Supporting publications (n) 6	Transmembrane count	Protein classification Disease related genesPredicted intracellular proteins

Basic Information

Protein Names

Tubby protein homolog

Protein Class (2)

Disease related genesPredicted intracellular proteins

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000166402

Entrez Gene Symbol

TUB

Gene Synonym

rd5

Gene Description

TUB bipartite transcription factor

Chromosome

Position

8019244-8106243

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization

Cell SpecificMicrogliaSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

Mediation Categories (3)

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence188

Ligand-Receptor Signaling (17)

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted
plasma_membrane	plasma_membrane	OmniPath			Yes
secreted	secreted	UniProt_keyword			Yes
secreted	secreted	UniProt_location			Yes
secreted	secreted	OmniPath			Yes
ligand	ligand	CellChatDB	Yes		Yes
ligand	ligand	OmniPath	Yes		Yes
receptor	receptor	CellCellInteractions		Yes	Yes

Page 2 of 2Previous

Protein Complex Composition (170)

170 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ACTB MZT1 TUBG1 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6	P23258 P60709 Q08AG7 Q96CW5 Q96RT7 Q96RT8 Q9BSJ2 Q9UGJ1	14:1:2:6:2:1:5:2	PDB	PDB:8vrdPDB:9i8hPDB:9i8gPDB:7qj9PDB:7as4PDB:7qj6
TUBA1B TUBG1	P23258 P68363	2:2	PDB	PDB:8va2
MZT1 MZT2A MZT2B NEDD1 NME7 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6	P23258 Q08AG7 Q6NZ67 Q6P582 Q8NHV4 Q96CW5 Q96RT7 Q96RT8 Q9BSJ2 Q9NRH3 Q9UGJ1 Q9Y5B8	0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
MZT1 MZT2A MZT2B NEDD1 NME7 TUBG1 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6	P23258 Q08AG7 Q6NZ67 Q6P582 Q8NHV4 Q96CW5 Q96RT7 Q96RT8 Q9BSJ2 Q9UGJ1 Q9Y5B8	0:0:0:0:0:0:0:0:0:0:0	hu.MAP
MZT1 MZT2A MZT2B TUBG1 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6	P23258 Q08AG7 Q6NZ67 Q6P582 Q96CW5 Q96RT7 Q96RT8 Q9BSJ2 Q9UGJ1	0:0:0:0:0:0:0:0:0	hu.MAP2
MZT1 MZT2A MZT2B NME7 TUBG1 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6	P23258 Q08AG7 Q6NZ67 Q6P582 Q96CW5 Q96RT7 Q96RT8 Q9BSJ2 Q9UGJ1 Q9Y5B8	0:0:0:0:0:0:0:0:0:0	hu.MAP2
MZT1 TUBG1 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6	P23258 Q08AG7 Q96CW5 Q96RT7 Q96RT8 Q9BSJ2 Q9UGJ1	6:2:2:1:2:1:2	PDB	PDB:7qj0PDB:7qj2PDB:7qjdPDB:7qj1PDB:7qj3PDB:7qj4
CDC5L H2BC26 SNW1 TUBG1 TUBGCP2 TUBGCP3 TUBGCP4	P23258 Q13573 Q8N257 Q96CW5 Q99459 Q9BSJ2 Q9UGJ1	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6126
CDC5L SNW1 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4	P23258 Q13573 Q96CW5 Q99459 Q9BSJ2 Q9NRH3 Q9UGJ1	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9436
CIZ1 EIF4H HECW2 MRPL1 MRPL18 MRPL23 MRPL58 MRPS30 TUBG1	P23258 Q14197 Q15056 Q16540 Q9BYD6 Q9H0U6 Q9NP92 Q9P2P5 Q9ULV3	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7128

Page 12 of 17Previous Next

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	3	38343172 40222457 40595564

Sequence, Structure & Domains

Sequences

Length

506

Mass

55,651

Sequence

MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50607-1; Sequence=Displayed; Name=2; IsoId=P50607-2; Sequence=VSP_023030

Alternative Sequence

1..13; MTSKPHSDWIPYS -> MGARTPLPSFWVSFFAETGILFPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIAR (in isoform 2)

3D Structural Models

Turn

355..357; 434..437

Helix

251..255; 276..278; 318..322; 406..408; 410..415; 488..500

Beta Strand

265..272; 283..289; 295..303; 311..316; 329..334; 338..348; 358..363; 366..372; 385..390; 421..427; 431..433; 438..440; 455..459; 467..474; 477..482

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

70..87; Low complexity; 101..116; Low complexity; 196..206; Acidic residues; 207..221; Low complexity; 230..243; Low complexity

Region

36..244; Disordered

Protein Families

TUB family

Sequence Similarities

Belongs to the TUB family.

Clinical Relevance

Disease Involvement

Obesity

Related Diseases (12)

Obesity Bladder cancer Brain cancer Breast cancer Central nervous system disease Epidermal dysplasias Gout Immune system disease Ovarian cancer Pancreatic cancer Sarcoma Solid tumour/cancer

Biomarker

Discontinued in Phase 3; Phase 1; Approved; Investigative; Discontinued in Phase 1; Phase 3; Phase 2

Drugs (17)

VINORELBINE COLCHICINE LISAVANBULIN NULL CRYPTOPHYCIN 52 INDIBULIN SOBLIDOTIN ERIBULIN MESYLATE E-7974 DOLASTATIN-10 BMS-184476 IXABEPILONE BMS-275183 BMS-188797 CABAZITAXEL MILATAXEL DOCETAXEL ANHYDROUS

Antibody (2)

HPA017997 HPA049019

Supporting Publications6

PMID	Title	Related sentences
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No related sentences available
35111156	Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response.	No related sentences available
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No related sentences available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No related sentences available
39290459	Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.	No related sentences available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No related sentences available