Protein detail
TUB
Tubby protein homolog
Protein symbol TUB | UniProt ID | EVMP score 0.50 |
Frequency 6 | Transmembrane count | Protein classification Disease related genesPredicted intracellular proteins |
Basic Information
Protein Names
Tubby protein homolog
Protein Class
Disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
rd5
Gene Description
TUB bipartite transcription factor
Chromosome
11
Position
8019244-8106243
Frequency
6
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificMicrogliaSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| ligand | ligand | CellChatDB | Yes | No | Yes | No | No |
| ligand | ligand | OmniPath | Yes | No | Yes | No | No |
| receptor | receptor | CellCellInteractions | No | Yes | Yes | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
170 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| SVBPTUBA1BVASH2 | P68363Q86V25Q8N300 | 1:1:1 | PDB | PDB:6j4v | ||
| SVBPTUBA1BTUBB2BVASH2 | P68363Q86V25Q8N300Q9BVA1 | 2:1:1:4 | PDB | PDB:7zcw | ||
| TUBA1BTUBB2B | P68363Q9BVA1 | 1:1 | PDB | PDB:6e7c | ||
| TUBA4ATUBB2B | P68366Q9BVA1 | 0:0 | hu.MAP | |||
| TUBA1ATUBB4B | P68371Q71U36 | 1:1 | hu.MAPPDB | PDB:8sh7 | ||
| DTWD2NAAATUBB8 | Q02083Q3ZCM7Q8NBA8 | 0:0:0 | hu.MAP2 | |||
| MZT1TUBGCP3TUBGCP6 | Q08AG7Q96CW5Q96RT7 | 2:1:1 | PDB | PDB:6x0u | ||
| MZT1TUBGCP6 | Q08AG7Q96RT7 | 1:1 | PDB | PDB:6m33 | ||
| MZT1TUBGCP5 | Q08AG7Q96RT8 | 2:2 | PDB | PDB:6l81 | ||
| DLGAP5TUBB3 | Q13509Q15398 | 0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
506
Mass
55,651
Sequence
MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50607-1; Sequence=Displayed; Name=2; IsoId=P50607-2; Sequence=VSP_023030
Alternative Sequence
1..13; MTSKPHSDWIPYS -> MGARTPLPSFWVSFFAETGILFPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIAR (in isoform 2)
3D Structural Models
Turn
355..357; 434..437
Helix
251..255; 276..278; 318..322; 406..408; 410..415; 488..500
Beta Strand
265..272; 283..289; 295..303; 311..316; 329..334; 338..348; 358..363; 366..372; 385..390; 421..427; 431..433; 438..440; 455..459; 467..474; 477..482
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
70..87; Low complexity; 101..116; Low complexity; 196..206; Acidic residues; 207..221; Low complexity; 230..243; Low complexity
Region
36..244; Disordered
Protein Families
TUB family
Sequence Similarities
Belongs to the TUB family.
Clinical Relevance
Disease Involvement
Obesity
Related Diseases
Biomarker
Discontinued in Phase 3; Phase 1; Approved; Investigative; Discontinued in Phase 1; Phase 3; Phase 2
Drugs