Protein detail
TUB
Tubby protein homolog
Entry name TUB | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 6 | Transmembrane count | Protein classification Disease related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Tubby protein homolog
Protein Class (2)
Disease related genesPredicted intracellular proteins
Protein Function (2)
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
rd5
Gene Description
TUB bipartite transcription factor
Chromosome
11
Position
8019244-8106243
Supporting publications (n)
6
EVMP confidence score
0.38
Fluorescence & Localization
Cell SpecificMicrogliaSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function (2)
- Disease related genes
- Predicted intracellular proteins
Cellular Component (6)
Molecular Function (3)
Biological Process (3)
Mediation Categories (3)
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence188
Ligand-Receptor Signaling (17)
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | Yes | |||
| ecm | ecm | MatrixDB | Yes | Yes | |||
| ecm | ecm | OmniPath | Yes | Yes | |||
| extracellular | extracellular | OmniPath | Yes | ||||
| intracellular | intracellular | LOCATE | Yes | ||||
| intracellular | intracellular | ComPPI | Yes | ||||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | UniProt_location | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | Yes |
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Protein Complex Composition (170)
170 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| MZT2BTUBGCP2 | Q6NZ67Q9BSJ2 | 0:0 | hu.MAP2 | |||
| EML6TUBB2B | Q6ZMW3Q9BVA1 | 0:0 | hu.MAP | |||
| SVBPTUBA1AVASH1 | Q71U36Q7L8A9Q8N300 | 1:1:1 | PDB | PDB:6j8f | ||
| TEDC1TEDC2TUBD1TUBE1 | Q7L2K0Q86SX3Q9UJT0Q9UJT1 | 0:0:0:0 | hu.MAP2 | |||
| TEDC2TUBD1TUBE1 | Q7L2K0Q9UJT0Q9UJT1 | 0:0:0 | hu.MAPhu.MAP2 | |||
| OTUB1OTUD6B | Q8N6M0Q96FW1 | 0:0 | Havugimana2012hu.MAP | Havugimana2012:C_7 | ||
| TUBGCP2TUBGCP3 | Q96CW5Q9BSJ2 | 1:1 | PDB | PDB:6v6b | ||
| TUBGCP4TUBGCP5 | Q96RT8Q9UGJ1 | 1:1 | PDB | PDB:6v69 | ||
| TUBA1CTUBB6 | Q9BQE3Q9BUF5 | 0:0 | hu.MAP2 | |||
| STUB1 | Q9UNE7 | 2 | PDB | PDB:8f15PDB:9dryPDB:8f16PDB:8f17PDB:6nsvPDB:8ehzPDB:6efkPDB:7tb1 |
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Sequence, Structure & Domains
Sequences
Length
506
Mass
55,651
Sequence
MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50607-1; Sequence=Displayed; Name=2; IsoId=P50607-2; Sequence=VSP_023030
Alternative Sequence
1..13; MTSKPHSDWIPYS -> MGARTPLPSFWVSFFAETGILFPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIAR (in isoform 2)
3D Structural Models
Turn
355..357; 434..437
Helix
251..255; 276..278; 318..322; 406..408; 410..415; 488..500
Beta Strand
265..272; 283..289; 295..303; 311..316; 329..334; 338..348; 358..363; 366..372; 385..390; 421..427; 431..433; 438..440; 455..459; 467..474; 477..482
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
70..87; Low complexity; 101..116; Low complexity; 196..206; Acidic residues; 207..221; Low complexity; 230..243; Low complexity
Region
36..244; Disordered
Protein Families
TUB family
Sequence Similarities
Belongs to the TUB family.
Clinical Relevance
Disease Involvement
Obesity
Related Diseases (12)
Biomarker
Discontinued in Phase 3; Phase 1; Approved; Investigative; Discontinued in Phase 1; Phase 3; Phase 2
Drugs (17)
Supporting Publications6
| PMID | Title | Related sentences |
|---|---|---|
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No related sentences available |
| 35111156 | Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response. | No related sentences available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No related sentences available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No related sentences available |
| 39290459 | Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease. | No related sentences available |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No related sentences available |