Protein detail

TUB

Tubby protein homolog

Entry name TUB	UniProt ID P50607	EVMP confidence score 0.50
Supporting publications (n) 6	Transmembrane count	Protein classification Disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Tubby protein homolog

Protein Class (2)

Disease related genesPredicted intracellular proteins

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000166402

Entrez Gene Symbol

TUB

Gene Synonym

rd5

Gene Description

TUB bipartite transcription factor

Chromosome

Position

8019244-8106243

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Cell SpecificMicrogliaSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway5

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

Mediation Categories (3)

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence188

Ligand-Receptor Signaling (17)

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No
ligand	ligand	CellChatDB	Yes	No	Yes	No	No
ligand	ligand	OmniPath	Yes	No	Yes	No	No
receptor	receptor	CellCellInteractions	No	Yes	Yes	No	No

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Protein Complex Composition (170)

170 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
ubiquitin conjugating enzyme complex	STUB1 UBE2V1	Q13404 Q9UNE7	1:1	Compleat	Compleat:HC2857	16307917 16129784
	A0A0A0MRG9 ACTB MZT1 MZT2B NEDD1 TUBG1 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6	A0A0A0MRG9 P23258 P60709 Q08AG7 Q6NZ67 Q8NHV4 Q96CW5 Q96RT7 Q96RT8 Q9BSJ2 Q9UGJ1	2:14:1:7:1:4:10:1:1:5:2	PDB	PDB:9qvm
	HERC5 RBM47 RBM4B RPL13 TUBA8	A0AV96 P26373 Q9BQ04 Q9NY65 Q9UII4	0:0:0:0:0	hu.MAP2
	A1CF RBM46 RBM47 RBM4B TUBA8	A0AV96 Q8TBY0 Q9BQ04 Q9NQ94 Q9NY65	0:0:0:0:0	hu.MAP2
	A1CF RBM47 TUBA8	A0AV96 Q9NQ94 Q9NY65	0:0:0	hu.MAP2
	TUBAL3 TXNDC9	A6NHL2 O14530	0:0	hu.MAP2
	CCT6B CYP27A1 TUBAL3 TXNDC9	A6NHL2 O14530 Q02318 Q92526	0:0:0:0	hu.MAP2
	EML1 EML2 TUBB2A	O00423 O95834 Q13885	0:0:0	hu.MAP
	AHSA1 DNM1L PMM2 SUMO2 TUBA1B TUBB6 UBC	O00429 O15305 O95433 P0CG48 P61956 P68363 Q9BUF5	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9252
	ECH1 PEX14 PEX5 PEX7 RPS15A TUBB2A	O00628 O75381 P50542 P62244 Q13011 Q13885	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6184

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	3	38343172 40222457 40595564

Sequence, Structure & Domains13

Sequences

Length

506

Mass

55,651

Sequence

MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50607-1; Sequence=Displayed; Name=2; IsoId=P50607-2; Sequence=VSP_023030

Alternative Sequence

1..13; MTSKPHSDWIPYS -> MGARTPLPSFWVSFFAETGILFPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIAR (in isoform 2)

3D Structural Models

Turn

355..357; 434..437

Helix

251..255; 276..278; 318..322; 406..408; 410..415; 488..500

Beta Strand

265..272; 283..289; 295..303; 311..316; 329..334; 338..348; 358..363; 366..372; 385..390; 421..427; 431..433; 438..440; 455..459; 467..474; 477..482

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

70..87; Low complexity; 101..116; Low complexity; 196..206; Acidic residues; 207..221; Low complexity; 230..243; Low complexity

Region

36..244; Disordered

Protein Families

TUB family

Sequence Similarities

Belongs to the TUB family.

Clinical Relevance5

Disease Involvement

Obesity

Related Diseases (11)

Bladder cancer Brain cancer Breast cancer Central nervous system disease Epidermal dysplasias Gout Immune system disease Ovarian cancer Pancreatic cancer Sarcoma Solid tumour/cancer

Biomarker

Discontinued in Phase 3; Phase 1; Approved; Investigative; Discontinued in Phase 1; Phase 3; Phase 2

Drugs (17)

VINORELBINE COLCHICINE LISAVANBULIN NULL CRYPTOPHYCIN 52 INDIBULIN SOBLIDOTIN ERIBULIN MESYLATE E-7974 DOLASTATIN-10 BMS-184476 IXABEPILONE BMS-275183 BMS-188797 CABAZITAXEL MILATAXEL DOCETAXEL ANHYDROUS

Antibody (2)

HPA017997 HPA049019

Supporting Publications6

PMID	Title	Abstract
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
35111156	Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response.	No abstract available
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
39290459	Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.	No abstract available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No abstract available