Protein detail

TUB

Tubby protein homolog

Entry name TUB	UniProt ID P50607	EVMP confidence score 0.38
Supporting publications (n) 6	Transmembrane count	Protein classification Disease related genesPredicted intracellular proteins

Basic Information

Protein Names

Tubby protein homolog

Protein Class (2)

Disease related genesPredicted intracellular proteins

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000166402

Entrez Gene Symbol

TUB

Gene Synonym

rd5

Gene Description

TUB bipartite transcription factor

Chromosome

Position

8019244-8106243

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization

Cell SpecificMicrogliaSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

Mediation Categories (3)

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence188

Ligand-Receptor Signaling (17)

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted
receptor	receptor	OmniPath		Yes	Yes
ecm	ecm	MatrixDB	Yes		Yes
ecm	ecm	OmniPath	Yes		Yes
extracellular	extracellular	OmniPath			Yes
intracellular	intracellular	LOCATE			Yes
intracellular	intracellular	ComPPI			Yes
intracellular	intracellular	GO_Intercell			Yes
intracellular	intracellular	UniProt_location			Yes
intracellular	intracellular	OmniPath			Yes
plasma_membrane	plasma_membrane	UniProt_location			Yes

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Protein Complex Composition (170)

170 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ATAD3A TUBA1C TUBB4A TUBB6	P04350 Q9BQE3 Q9BUF5 Q9NVI7	0:0:0:0	hu.MAP
ANP32B NOP10 RBM4B RPLP0 TUBA8	P05388 Q92688 Q9BQ04 Q9NPE3 Q9NY65	0:0:0:0:0	hu.MAP2
CSNK1A1 HSP90AA1 SYT11 SYT9 TUBB	P07437 P07900 P48729 Q86SS6 Q9BT88	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6200
CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 TCP1 TUBB	P07437 P17987 P40227 P48643 P49368 P50990 P50991 P78371 Q99832	1:2:2:2:2:2:2:2:2	PDB	PDB:7tubPDB:7ttnPDB:7tttPDB:7trgPDB:7x0s
CAD Q99867 TUBA1A TUBA1B TUBA1C TUBA4A TUBB TUBB2A TUBB3 TUBB4B TUBB6	P07437 P27708 P68363 P68366 P68371 Q13509 Q13885 Q71U36 Q99867 Q9BQE3 Q9BUF5	0:0:0:0:0:0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_596
CLIP1 DNAH8 HCFC1 PAFAH1B1 TUBA1A TUBB	P07437 P30622 P43034 P51610 Q71U36 Q96JB1	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9767
POLR2B TUBB TUBB2A TUBB4B	P07437 P30876 P68371 Q13885	0:0:0:0	hu.MAP
TUBA1B TUBB	P07437 P68363	6:6	PDB	PDB:9bp6PDB:5n5nPDB:6i2iPDB:8v2j
CAMSAP1 TUBA1B TUBB	P07437 P68363 Q5T5Y3	2:2:1	PDB	PDB:6qusPDB:6qvj
TUBB TUBB4B	P07437 P68371	0:0	hu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	3	38343172 40222457 40595564

Sequence, Structure & Domains

Sequences

Length

506

Mass

55,651

Sequence

MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50607-1; Sequence=Displayed; Name=2; IsoId=P50607-2; Sequence=VSP_023030

Alternative Sequence

1..13; MTSKPHSDWIPYS -> MGARTPLPSFWVSFFAETGILFPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIAR (in isoform 2)

3D Structural Models

Turn

355..357; 434..437

Helix

251..255; 276..278; 318..322; 406..408; 410..415; 488..500

Beta Strand

265..272; 283..289; 295..303; 311..316; 329..334; 338..348; 358..363; 366..372; 385..390; 421..427; 431..433; 438..440; 455..459; 467..474; 477..482

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

70..87; Low complexity; 101..116; Low complexity; 196..206; Acidic residues; 207..221; Low complexity; 230..243; Low complexity

Region

36..244; Disordered

Protein Families

TUB family

Sequence Similarities

Belongs to the TUB family.

Clinical Relevance

Disease Involvement

Obesity

Related Diseases (12)

Obesity Bladder cancer Brain cancer Breast cancer Central nervous system disease Epidermal dysplasias Gout Immune system disease Ovarian cancer Pancreatic cancer Sarcoma Solid tumour/cancer

Biomarker

Discontinued in Phase 3; Phase 1; Approved; Investigative; Discontinued in Phase 1; Phase 3; Phase 2

Drugs (17)

VINORELBINE COLCHICINE LISAVANBULIN NULL CRYPTOPHYCIN 52 INDIBULIN SOBLIDOTIN ERIBULIN MESYLATE E-7974 DOLASTATIN-10 BMS-184476 IXABEPILONE BMS-275183 BMS-188797 CABAZITAXEL MILATAXEL DOCETAXEL ANHYDROUS

Antibody (2)

HPA017997 HPA049019

Supporting Publications6

PMID	Title	Related sentences
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No related sentences available
35111156	Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response.	No related sentences available
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No related sentences available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No related sentences available
39290459	Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.	No related sentences available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No related sentences available