Protein detail

TUB

Tubby protein homolog

Entry name TUB	UniProt ID P50607	EVMP confidence score 0.50
Supporting publications (n) 6	Transmembrane count	Protein classification Disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Tubby protein homolog

Protein Class (2)

Disease related genesPredicted intracellular proteins

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000166402

Entrez Gene Symbol

TUB

Gene Synonym

rd5

Gene Description

TUB bipartite transcription factor

Chromosome

Position

8019244-8106243

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Cell SpecificMicrogliaSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway5

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

Mediation Categories (3)

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence188

Ligand-Receptor Signaling (17)

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No
ligand	ligand	CellChatDB	Yes	No	Yes	No	No
ligand	ligand	OmniPath	Yes	No	Yes	No	No
receptor	receptor	CellCellInteractions	No	Yes	Yes	No	No

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Protein Complex Composition (170)

170 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
2A-DUB	EEF1A1 HNRNPH1 HSPA1B KAT2B KIF11 MYSM1 RBM10 TUBB	P07437 P0DMV9 P31943 P52732 P68104 P98175 Q5VVJ2 Q92831	1:1:1:1:1:1:1:1	Compleat	Compleat:HC1776	17707232
BAG3-HSC70-HSPB8-CHIP complex	BAG3 HSPA8 HSPB8 STUB1	O95817 P11142 Q9UJY1 Q9UNE7	0:0:0:0	CORUM	CORUM:6052	20060297
Gamma tubulin ring complex	ACTB MZT1 MZT2A MZT2B TUBG1 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6	P23258 P60709 Q08AG7 Q6NZ67 Q6P582 Q96CW5 Q96RT7 Q96RT8 Q9BSJ2 Q9UGJ1	14:1:2:2:3:5:1:1:5:2	ComplexPortal	PDB:7QJ0PDB:8VRKPDB:7QJEintact:EBI-61258233PDB:7QJ8PDB:6M33PDB:7QJ9PDB:8VT7PDB:7QJ6PDB:7QJBPDB:8VRJPDB:7QJAPDB:8VRDPDB:8VA2PDB:6X0UPDB:7QJ3PDB:7QJCPDB:7QJ5PDB:7QJ1PDB:7QJDPDB:7QJ2PDB:7QJ7PDB:7QJ4PDB:6V69	32610146 39321809 38609662 38609661 38956170 14755292 31862189 35078983
Gamma-tubulin complex	TUBG1 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6	P23258 Q96CW5 Q96RT7 Q96RT8 Q9BSJ2 Q9UGJ1	14:5:1:1:5:2	CORUMPDB	CORUM:6893PDB:6v6sPDB:8q62	11694571
HT_DM_Cluster27	CHKB CLXN CPT1A CPT1B CPT1C HARS1 HARS2 HES2 HES3 HES5 HES6 HES7 HPGD IDH1 PAX3 PAX7 PAX9 PDE8A PDE8B RAB14 TUBB TUBB2A TUBB2B TUBB4A TUBB4B	O60658 O75874 O95263 P04350 P07437 P12081 P15428 P23759 P23760 P49590 P50416 P55771 P61106 P68371 Q13885 Q5TA89 Q5TGS1 Q8TCG5 Q92523 Q96HZ4 Q9BVA1 Q9BYE0 Q9HAE3 Q9Y259 Q9Y543	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC1281	22036573
HT_SC_Cluster182	RANGAP1 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBE1 XPO1	O14980 P04350 P07437 P46060 P68371 Q13509 Q13885 Q3ZCM7 Q9BUF5 Q9BVA1 Q9H4B7 Q9UJT0	1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC3582
HT_SC_Cluster384	GBF1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBAL3	A6NHL2 P0DPH7 P0DPH8 P68363 P68366 Q6PEY2 Q71U36 Q92538 Q9BQE3 Q9NY65	1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2773
OTUB1-UBC13-MMS2 complex	OTUB1 UBE2N UBE2V2	P61088 Q15819 Q96FW1	18:18:6	CORUMPDB	CORUM:7051PDB:3von	22679021
PBAF	ACTB ACTL6A ARID2 PBRM1 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD3 SMARCE1 TUBB	O96019 P07437 P51532 P60709 Q12824 Q68CP9 Q6STE5 Q86U86 Q8TAQ2 Q92922 Q969G3 Q96GM5	1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC1852	11078522 14701856 8804307 15985610 11780067
Pericentrin-GCP complex	PCNT TUBGCP2 TUBGCP3	O95613 Q96CW5 Q9BSJ2	1:1:1	CompleatCORUM	CORUM:3714Compleat:HC751	15146056

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	3	38343172 40222457 40595564

Sequence, Structure & Domains13

Sequences

Length

506

Mass

55,651

Sequence

MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50607-1; Sequence=Displayed; Name=2; IsoId=P50607-2; Sequence=VSP_023030

Alternative Sequence

1..13; MTSKPHSDWIPYS -> MGARTPLPSFWVSFFAETGILFPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIAR (in isoform 2)

3D Structural Models

Turn

355..357; 434..437

Helix

251..255; 276..278; 318..322; 406..408; 410..415; 488..500

Beta Strand

265..272; 283..289; 295..303; 311..316; 329..334; 338..348; 358..363; 366..372; 385..390; 421..427; 431..433; 438..440; 455..459; 467..474; 477..482

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

70..87; Low complexity; 101..116; Low complexity; 196..206; Acidic residues; 207..221; Low complexity; 230..243; Low complexity

Region

36..244; Disordered

Protein Families

TUB family

Sequence Similarities

Belongs to the TUB family.

Clinical Relevance5

Disease Involvement

Obesity

Related Diseases (11)

Bladder cancer Brain cancer Breast cancer Central nervous system disease Epidermal dysplasias Gout Immune system disease Ovarian cancer Pancreatic cancer Sarcoma Solid tumour/cancer

Biomarker

Discontinued in Phase 3; Phase 1; Approved; Investigative; Discontinued in Phase 1; Phase 3; Phase 2

Drugs (17)

VINORELBINE COLCHICINE LISAVANBULIN NULL CRYPTOPHYCIN 52 INDIBULIN SOBLIDOTIN ERIBULIN MESYLATE E-7974 DOLASTATIN-10 BMS-184476 IXABEPILONE BMS-275183 BMS-188797 CABAZITAXEL MILATAXEL DOCETAXEL ANHYDROUS

Antibody (2)

HPA017997 HPA049019

Supporting Publications6

PMID	Title	Abstract
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
35111156	Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response.	No abstract available
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
39290459	Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.	No abstract available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No abstract available