Protein detail
RAB13
Ras-related protein Rab-13 (EC 3.6.5.2) (Cell growth-inhibiting gene 4 protein)
Entry name RAB13 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ras-related protein Rab-13 (EC 3.6.5.2) (Cell growth-inhibiting gene 4 protein)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
RAB13, member RAS oncogene family
Chromosome
1
Position
153981617-153986358
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEarly spermatids
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
- GO:0005768 endosome
- GO:0005802 trans-Golgi network
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005923 bicellular tight junction
- GO:0008021 synaptic vesicle
- GO:0016328 lateral plasma membrane
- GO:0030027 lamellipodium
- GO:0030054 cell junction
- GO:0030139 endocytic vesicle
- GO:0030140 trans-Golgi network transport vesicle
- GO:0031410 cytoplasmic vesicle
- GO:0032593 insulin-responsive compartment
- GO:0043005 neuron projection
- GO:0055037 recycling endosome
- GO:0055038 recycling endosome membrane
- GO:0070062 extracellular exosome
Biological Process
Reactome
- R-hsa-199991 membrane trafficking
- R-hsa-597592 post translational protein modification
- R-hsa-8876198 rab gefs exchange gtp for gdp on rabs
- R-hsa-8873719 rab geranylgeranylation
- R-hsa-9007101 rab regulation of trafficking
- R-hsa-1445148 translocation of slc2a4 glut4 to the plasma membrane
- R-hsa-5653656 vesicle mediated transport
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| RAB13 | PINK1 | Q9BXM7 | S | 111 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:28017782 |
Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | No | No | No |
| tight_junction | tight_junction | Ramilowski_location | Yes | Yes | No | No | No |
| tight_junction | tight_junction | OmniPath | Yes | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
203
Mass
22,774
Sequence
MAKAYDHLFKLLLIGDSGVGKTCLIIRFAEDNFNNTYISTIGIDFKIRTVDIEGKKIKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSFENIQNWMKSIKENASAGVERLLLGNKCDMEAKRKVQKEQADKLAREHGIRFFETSAKSSMNVDEAFSSLARDILLKSGGRRSGNGNKPPSTDLKTCDKKNTNKCSLG
3D Structural Models
Domain & Motif Annotations
Compositional Bias
179..189; Polar residues
Motif
31..45; Switch 1; 63..80; Switch 2
Domain (CC)
Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.
Region
173..203; Disordered
Protein Families
- Small GTPase superfamily
- Rab family
Sequence Similarities
Belongs to the small GTPase superfamily. Rab family.
Clinical Relevance
Antibody
Interaction Protein
ENSG00000183155ENSG00000203879
Interaction Count
2
Interaction Dataset
biogrid_opencell_bioplex