Protein detail
SCNNG
Epithelial sodium channel subunit gamma (ENaC subunit gamma) (ENaCG) (Epithelial Na(+) channel subunit gamma) (Gamma-ENaC) (Amiloride-sensitive sodium channel subunit gamma) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG) (Sodium channel epithelial 1 subunit gamma)
Entry name SCNNG | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 4 | Transmembrane count 2 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Epithelial sodium channel subunit gamma (ENaC subunit gamma) (ENaCG) (Epithelial Na(+) channel subunit gamma) (Gamma-ENaC) (Amiloride-sensitive sodium channel subunit gamma) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG) (Sodium channel epithelial 1 subunit gamma)
Protein Function (6)
- Human disease related genes:Urinary system diseases:Kidney diseases
- Human disease related genes:Cardiovascular diseases:Hypertensive diseases
- Transporters:Transporter channels and pores
- Disease related genes
- Human disease related genes:Respiratory diseases:Tracheobronchial diseases
- FDA approved drug targets:Small molecule drugs
Transmembrane
56..76; Helical; Name=1; 542..562; Helical; Name=2
Transmembrane Count
2
Ensembl
Entrez Gene Symbol
Supporting publications (n)
4
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function (6)
- Human disease related genes:Urinary system diseases:Kidney diseases
- Human disease related genes:Cardiovascular diseases:Hypertensive diseases
- Transporters:Transporter channels and pores
- Disease related genes
- Human disease related genes:Respiratory diseases:Tracheobronchial diseases
- FDA approved drug targets:Small molecule drugs
Cellular Component (6)
Molecular Function (5)
Biological Process (3)
Reactome (6)
Canonical Pathways
M7 Pid fcer1 pathway
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence43
Enzyme-Mediated Modification (8)
8 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SCNN1G | MAPK3 | P27361 | T | 622 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:11805112ProtMapper:11805112 |
| SCNN1G | MAPK1 | P28482 | T | 622 | phosphorylation | MIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:11805112ProtMapper:11805112KEA:11805112 |
| SCNN1G | NEDD4 | P46934 | K | 10 | ubiquitination | HPRD | HPRD:9351815 |
| SCNN1G | NEDD4 | P46934 | K | 12 | ubiquitination | HPRD | HPRD:9351815 |
| SCNN1G | NEDD4 | P46934 | K | 13 | ubiquitination | HPRD | HPRD:9351815 |
| SCNN1G | NEDD4 | P46934 | K | 26 | ubiquitination | HPRD | HPRD:9351815 |
| SCNN1G | NEDD4 | P46934 | K | 6 | ubiquitination | HPRD | HPRD:9351815 |
| SCNN1G | NEDD4 | P46934 | K | 8 | ubiquitination | HPRD | HPRD:9351815 |
Ligand-Receptor Signaling (28)
28 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transporter | transporter | OmniPath | Yes | ||||
| ion_channel | ion_channel | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane | transmembrane | TopDB | |||||
| transmembrane | transmembrane | LOCATE | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location |
Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SCNNG | P51170 | CAC1H | O95180 | Yes | Yes | SIGNOR | SIGNOR:30736831 | |
| MK03 | P27361 | SCNNG | P51170 | Yes | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | SIGNOR:11805112ProtMapper:11805112 | |
| MK01 | P28482 | SCNNG | P51170 | Yes | Yes | MIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | SIGNOR:11805112ProtMapper:11805112HPRD:11805112KEA:11805112 |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| SCNN1A-SCNN1B-SCNN1G complex | SCNN1ASCNN1BSCNN1G | P37088P51168P51170 | 1:1:1 | CORUMComplexPortalPDB | PDB:6bqnintact:EBI-9008990CORUM:6438PDB:6wth | 2404377615821171164238241213627574991952177543614755292 |
| CTSDNAPSASCNN1G | O96009P07339P51170 | 0:0:0 | hu.MAP | |||
| SCNN1BSCNN1G | P51168P51170 | 2:1 | PDB | PDB:9btgPDB:9btu |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
649
Mass
74,270
Sequence
MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSNQLTDTQMLDEL
3D Structural Models
Turn
107..109; 111..113; 278..280; 319..321; 375..378; 425..427; 450..452; 474..476; 488..491; 498..500
Helix
115..128; 153..157; 222..237; 238..240; 243..249; 253..256; 269..271; 314..316; 340..343; 366..370; 391..406; 432..443; 477..487
Beta Strand
81..90; 96..102; 161..163; 201..207; 214..221; 257..259; 265..267; 272..277; 281..287; 290..292; 301..311; 324..329; 334..336; 345..357; 359..363; 407..410; 412..414; 459..462; 465..469; 501..509; 512..520
3D Structure
Electron microscopy (5)
Domain & Motif Annotations
Motif
623..627; PY motif; recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L
Region
135..221; Gating release of inhibition by proteolysis (GRIP); protease-sensitive region that is responsible for the proteolytic activation of the channel
Protein Families (2)
- Amiloride-sensitive sodium channel (TC 1.A.6) family
- SCNN1G subfamily
Sequence Similarities
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.
Clinical Relevance
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
| 36064647 | Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |