Protein detail

SCNND

Epithelial sodium channel subunit delta (Delta-ENaC) (ENaCD) (Epithelial Na(+) channel subunit delta) (Amiloride-sensitive sodium channel subunit delta) (Delta-NaCH) (Nonvoltage-gated sodium channel 1 subunit delta) (SCNED)

Entry name SCNND	UniProt ID P51172	EVMP score 0.50
Frequency 1	Transmembrane count 2	Protein classification FDA approved drug targetsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Class

FDA approved drug targetsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Transporter channels and pores
FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins

Transmembrane

251..271; Helical; Name=1; 695..715; Helical; Name=2

Transmembrane Count

Ensembl

ENSG00000162572

Entrez Gene Symbol

SCNN1D

Gene Synonym

dNaChENaCdelta

Gene Description

Sodium channel epithelial 1 subunit delta

Chromosome

Position

1280436-1292029

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificretinaCell SpecificColonocytes

Function & Pathway

Protein Function

Transporters:Transporter channels and pores
FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

26 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ion_channel	ion_channel	OmniPath	No	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
apical_cell_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

7 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
ABHD16A SCNN1D STX11 STX3 STXBP2	O75558 O95870 P51172 Q13277 Q15833	0:0:0:0:0	hu.MAP2
ABHD16A ANKHD1 SCNN1D STX11 STXBP2	O75558 O95870 P51172 Q15833 Q8IWZ3	0:0:0:0:0	hu.MAP2
ABHD16A GJA1 HTR3C SCNN1D TMEM186 TMTC3 WLS	O95870 P17302 P51172 Q5T9L3 Q6ZXV5 Q8WXA8 Q96B77	0:0:0:0:0:0:0	hu.MAP2
ABHD16A GJA1 HTR3C SCNN1D TMEM186 TMTC3	O95870 P17302 P51172 Q6ZXV5 Q8WXA8 Q96B77	0:0:0:0:0:0	hu.MAP2
ABHD16A SCNN1D	O95870 P51172	0:0	hu.MAP2
ABHD16A HTR3C SCNN1D TMTC3 WLS	O95870 P51172 Q5T9L3 Q6ZXV5 Q8WXA8	0:0:0:0:0	hu.MAP2
ABHD16A MTFR2 SCNN1D	O95870 P51172 Q6P444	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation；Ultrafiltration / Tangential Flow Filtration	Mass spectrometry	1	39025337

Sequence, Structure & Domains

Sequences

Length

802

Mass

87,850

Sequence

MRAVLSQKTTPLPRYLWPGHLSGPRRLTWSWCSDHRTPTCRELGSPHPTPCTGPARGWPRRGGGPCGFTSAGHVLCGYPLCLLSGPIQGCGTGLGDSSMAFLSRTSPVAAASFQSRQEARGSILLQSCQLPPQWLSTEAWTGEWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPTQHNAACKQGQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=P51172-3; Sequence=Displayed; Name=1; Synonyms=delta1; IsoId=P51172-1; Sequence=VSP_060000, VSP_060002; Name=2; Synonyms=delta2; IsoId=P51172-2; Sequence=VSP_060001

Alternative Sequence

1..164; Missing (in isoform 1); 1..98; Missing (in isoform 2); 165..185; PCHLKGWQHRPTQHNAACKQG -> MAEHRSMDGRMEAATRGGSHL (in isoform 1)

3D Structural Models

Turn

445..447; 481..483; 500..503; 587..589; 636..638

Helix

306..308; 309..326; 389..405; 436..438; 464..466; 553..569; 593..605; 611..614; 639..648

Beta Strand

294..298; 357..359; 369..375; 378..388; 408..411; 423..429; 432..434; 439..444; 448..452; 461..463; 467..473; 477..479; 487..494; 507..509; 513..525; 539..541; 546..549; 570..572; 618..632; 662..669

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Compositional Bias

166..176; Basic residues; 192..205; Pro residues

Region

145..211; Disordered; 738..777; Disordered

Protein Families

Amiloride-sensitive sodium channel (TC 1.A.6) family
SCNN1D subfamily

Sequence Similarities

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1D subfamily.

Clinical Relevance

Disease Involvement

FDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs

TRIAMTERENE AMILORIDE NULL 552-02

Antibody

HPA026884

Interaction Protein

ENSG00000173163

Interaction Count

Interaction Dataset

intact_biogrid