Protein detail

CCR3

C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)

Protein symbol CCR3	UniProt ID P51677	EVMP score 0.50
Frequency 1	Transmembrane count 7	Protein classification CD markersG-protein coupled receptorsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)

Protein Class

CD markersG-protein coupled receptorsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins
CD markers
G-protein coupled receptors:GPCRs excl olfactory receptors
G-protein coupled receptors:Chemokines and chemotactic factors receptors
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases

Transmembrane

35..62; Helical; Name=1; 73..93; Helical; Name=2; 108..129; Helical; Name=3; 147..171; Helical; Name=4; 204..223; Helical; Name=5; 240..264; Helical; Name=6; 282..305; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000183625

Entrez Gene Symbol

CCR3

Gene Synonym

CC-CKR-3CD193CKR3CMKBR3

Gene Description

C-C motif chemokine receptor 3

Chromosome

Position

46130890-46266706

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecifictestisCell SpecificEarly spermatids

Function & Pathway

Protein Function

Predicted intracellular proteins
CD markers
G-protein coupled receptors:GPCRs excl olfactory receptors
G-protein coupled receptors:Chemokines and chemotactic factors receptors
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

65 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
chemokine_interleukin_8_7tm_a	receptor	HPMR	No	Yes	No	Yes	No
rhodopsin	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	Surfaceome	No	Yes	No	Yes	No
class_a_rhodopsin	receptor	GPCRdb	No	Yes	No	Yes	No
class_a_rhodopsin_protein	receptor	GPCRdb	No	Yes	No	Yes	No
class_a_rhodopsin_protein_chemokine	receptor	GPCRdb	No	Yes	No	Yes	No
chemokine	receptor	ICELLNET	No	Yes	No	Yes	No
chemokine_cxc	receptor	ICELLNET	No	Yes	No	Yes	No
chemokine_cc	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CCL11	P51671	CCR3	P51677	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDCui2007Ramilowski2015_Baccin2019DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Guide2Pharma:10854442 Cellinker:10854442 Cellinker:8609214 HINT:25450766 scConnect:8642344 DIP:9169459 Baccin2019:8642344 HINT:23597562 CellTalkDB:10699158 Cellinker:9712872 HPRD:9712872 LRdb:10699158 connectomeDB2020:12761559 Cellinker:8642344 Cellinker:8676064 Guide2Pharma:12761559 DIP:10733106 connectomeDB2020:16339911 connectomeDB2020:9712872 Lit-BM-17:23597562 Baccin2019:10854442 scConnect:16339911 connectomeDB2020:8676064 scConnect:10488147 connectomeDB2020:8609214 scConnect:9276730 HINT:12218106 Cellinker:10488147 Baccin2019:12761559 Cellinker:9276730 HPRD:8609214 InnateDB:12218106 Lit-BM-17:10733106 Lit-BM-17:8642344 Baccin2019:8609214 scConnect:12761559 Guide2Pharma:9276730 Baccin2019:10488147 InnateDB:8642344 Lit-BM-17:9207005 Guide2Pharma:8642344 Baccin2019:16339911 Baccin2019:9276730 Guide2Pharma:16339911 HINT:8642344 Cellinker:12761559 Baccin2019:12149192 DIP:25450766 connectomeDB2020:9276730 Baccin2019:9005985 scConnect:10854442 Cellinker:16339911 HPRD:8642344 DIP:9207005 ICELLNET:22633458 Lit-BM-17:9169459 connectomeDB2020:8642344 connectomeDB2020:10854442 Baccin2019:8676064 Baccin2019:9712872 InnateDB:16102831 connectomeDB2020:10488147 SIGNOR:24702154 SIGNOR:10706854 Guide2Pharma:10488147 HPRD:8676064
CCL5	P13501	CCR3	P51677	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDCui2007DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDCellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	HPMR:8642344 DIP:10733106 HPRD:8642344 ICELLNET:22633458 SIGNOR:10734056 scConnect:8642344 HPRD:9289016 connectomeDB2020:8642344 connectomeDB2020:9289016 DIP:7622448 InnateDB:8642344 Guide2Pharma:8642344 HINT:11449371 HINT:8642344 BioGRID:8642344 Cellinker:9289016 LRdb:10699158 Cellinker:8642344

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	21630462

Sequence, Structure & Domains

Sequences

Length

355

Mass

41,044

Sequence

MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51677-1; Sequence=Displayed; Name=2; IsoId=P51677-2; Sequence=VSP_046704

Alternative Sequence

1; M -> MPFGIRMLLRAHKPGSSRRSEM (in isoform 2)

3D Structural Models

Turn

62..65; 206..208; 269..271

Helix

39..61; 68..95; 106..136; 138..144; 147..164; 166..169; 189..195; 196..200; 202..205; 209..226; 234..263; 265..268; 273..291; 293..302; 306..322

Beta Strand

176..181

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Related Diseases

Asthma Parkinsonism Vasomotor/allergic rhinitis

Biomarker

Discontinued in Phase 1; Phase 2

Drugs

DALUTRAFUSP ALFA QUEMLICLUSTAT YM-355179 MUPADOLIMAB COMPOUND 15 [PMID: 32045236]&ALPHA &BETA -METHYLENEADP RECOMBINANT CYTOKINE COMPOUND 49 [PMID: 36529947]NULL OLECLUMAB

Antibody

CAB003795 HPA069514