Protein detail

CCR3

C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)

Entry name CCR3	UniProt ID P51677	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification CD markersG-protein coupled receptorsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)

Protein Class (5)

CD markersG-protein coupled receptorsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

Protein Function (5)

Predicted intracellular proteins
CD markers
G-protein coupled receptors:GPCRs excl olfactory receptors
G-protein coupled receptors:Chemokines and chemotactic factors receptors
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases

Transmembrane

35..62; Helical; Name=1; 73..93; Helical; Name=2; 108..129; Helical; Name=3; 147..171; Helical; Name=4; 204..223; Helical; Name=5; 240..264; Helical; Name=6; 282..305; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000183625

Entrez Gene Symbol

CCR3

Gene Synonym (4)

CC-CKR-3CD193CKR3CMKBR3

Gene Description

C-C motif chemokine receptor 3

Chromosome

Position

46130890-46266706

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecifictestisCell SpecificEarly spermatids

Function & Pathway7

Protein Function (5)

Predicted intracellular proteins
CD markers
G-protein coupled receptors:GPCRs excl olfactory receptors
G-protein coupled receptors:Chemokines and chemotactic factors receptors
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases

Cellular Component (3)

Molecular Function (4)

Biological Process (3)

KEGG (6)

Reactome (6)

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence68

Ligand-Receptor Signaling (65)

65 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
gpcr	receptor	GPCRdb	No	Yes	No	Yes	No
cc_chemokine	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	HGNC	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CCL11	P51671	CCR3	P51677	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDCui2007Ramilowski2015_Baccin2019DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Guide2Pharma:10854442 Cellinker:10854442 Cellinker:8609214 HINT:25450766 scConnect:8642344 DIP:9169459 Baccin2019:8642344 HINT:23597562 CellTalkDB:10699158 Cellinker:9712872 HPRD:9712872 LRdb:10699158 connectomeDB2020:12761559 Cellinker:8642344 Cellinker:8676064 Guide2Pharma:12761559 DIP:10733106 connectomeDB2020:16339911 connectomeDB2020:9712872 Lit-BM-17:23597562 Baccin2019:10854442 scConnect:16339911 connectomeDB2020:8676064 scConnect:10488147 connectomeDB2020:8609214 scConnect:9276730 HINT:12218106 Cellinker:10488147 Baccin2019:12761559 Cellinker:9276730 HPRD:8609214 InnateDB:12218106 Lit-BM-17:10733106 Lit-BM-17:8642344 Baccin2019:8609214 scConnect:12761559 Guide2Pharma:9276730 Baccin2019:10488147 InnateDB:8642344 Lit-BM-17:9207005 Guide2Pharma:8642344 Baccin2019:16339911 Baccin2019:9276730 Guide2Pharma:16339911 HINT:8642344 Cellinker:12761559 Baccin2019:12149192 DIP:25450766 connectomeDB2020:9276730 Baccin2019:9005985 scConnect:10854442 Cellinker:16339911 HPRD:8642344 DIP:9207005 ICELLNET:22633458 Lit-BM-17:9169459 connectomeDB2020:8642344 connectomeDB2020:10854442 Baccin2019:8676064 Baccin2019:9712872 InnateDB:16102831 connectomeDB2020:10488147 SIGNOR:24702154 SIGNOR:10706854 Guide2Pharma:10488147 HPRD:8676064
CCL5	P13501	CCR3	P51677	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDCui2007DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDCellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	HPMR:8642344 DIP:10733106 HPRD:8642344 ICELLNET:22633458 SIGNOR:10734056 scConnect:8642344 HPRD:9289016 connectomeDB2020:8642344 connectomeDB2020:9289016 DIP:7622448 InnateDB:8642344 Guide2Pharma:8642344 HINT:11449371 HINT:8642344 BioGRID:8642344 Cellinker:9289016 LRdb:10699158 Cellinker:8642344

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	21630462

Sequence, Structure & Domains11

Sequences

Length

355

Mass

41,044

Sequence

MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51677-1; Sequence=Displayed; Name=2; IsoId=P51677-2; Sequence=VSP_046704

Alternative Sequence

1; M -> MPFGIRMLLRAHKPGSSRRSEM (in isoform 2)

3D Structural Models

Turn

62..65; 206..208; 269..271

Helix

39..61; 68..95; 106..136; 138..144; 147..164; 166..169; 189..195; 196..200; 202..205; 209..226; 234..263; 265..268; 273..291; 293..302; 306..322

Beta Strand

176..181

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance4

Related Diseases (3)

Asthma Parkinsonism Vasomotor/allergic rhinitis

Biomarker

Discontinued in Phase 1; Phase 2

Drugs (12)

DALUTRAFUSP ALFA QUEMLICLUSTAT YM-355179 MUPADOLIMAB COMPOUND 15 [PMID: 32045236]&ALPHA &BETA -METHYLENEADP RECOMBINANT CYTOKINE COMPOUND 49 [PMID: 36529947]NULL OLECLUMAB

Antibody (2)

CAB003795 HPA069514

Supporting Publications1

PMID	Title	Abstract
40545963	Extracellular Vesicle Proteome Analysis Improves Diagnosis of Recurrence in Triple-Negative Breast Cancer.	No abstract available