Protein detail

CCR4

C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)

Entry name CCR4	UniProt ID P51679	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 7	Protein classification CD markersFDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)

Protein Class (4)

CD markersFDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins

Protein Function (4)

G-protein coupled receptors:Chemokines and chemotactic factors receptors
G-protein coupled receptors:GPCRs excl olfactory receptors
CD markers
FDA approved drug targets:Biotech drugs

Transmembrane

40..67; Helical; Name=1; 78..98; Helical; Name=2; 112..133; Helical; Name=3; 151..175; Helical; Name=4; 207..226; Helical; Name=5; 243..267; Helical; Name=6; 285..308; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000183813

Entrez Gene Symbol

CCR4

Gene Synonym (6)

CC-CKR-4CD194ChemR13CKR4CMKBR4k5-5

Gene Description

C-C motif chemokine receptor 4

Chromosome

Position

32951644-32956349

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificAdrenal cortex cells

Function & Pathway6

Protein Function (4)

G-protein coupled receptors:Chemokines and chemotactic factors receptors
G-protein coupled receptors:GPCRs excl olfactory receptors
CD markers
FDA approved drug targets:Biotech drugs

Cellular Component (3)

Molecular Function (4)

KEGG (5)

Reactome (6)

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence70

Ligand-Receptor Signaling (68)

68 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	Kirouac2010	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CCL2	P13500	CCR4	P51679	Yes	Yes	No	Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKKEGG-MEDICUStalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019WangLRdbCellCallHPMR_talklr	SIGNOR:17160712 Baccin2019:16421945 LRdb:16421945 CellTalkDB:16421945 connectomeDB2020:16421945

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	12645951

Sequence, Structure & Domains5

Sequences

Length

360

Mass

41,403

Sequence

MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance6

Disease Involvement

FDA approved drug targets

Related Diseases (10)

Asthma Diabetes mellitus Immune system disease Immunoproliferative disorder Lymphatic vessel/lymph nodes disorder Lymphoma Mature T-cell lymphoma Mycosis fungoides Sezary syndrome Solid tumour/cancer

Biomarker

Phase 2; Investigative; Phase 1; Approved; Phase 1/2

Drug Targets

FDA approved drug targets

Drugs (16)

[125I]CCL27 (HUMAN)MOGAMULIZUMAB FLX475 3-DEAZAADENOSINE AZD1678 AZD2098 VMIP-III GSK2239633A ZELNECIRNON COMPOUND 31 [PMID: 31259550]AUTOLOGOUS CCR4-CD30CAR-CD28-CD3ZETA-EXPRESSING T-LYMPHOCYTES [125I]CCL17 (HUMAN)GSK-2239633 COMPOUND 8IC [PMID: 19081254]CCL17 CCL22

Antibody

HPA031613

Supporting Publications2

PMID	Title	Abstract
36982991	Extracellular Vesicles of COVID-19 Patients Reflect Inflammation, Thrombogenicity, and Disease Severity.	Severe patients' EVs displayed higher percentages of small EVs (<150 nm) with increased expression of exosome marker CD63.
38922971	PLA2G2D promotes immune escape in non-small cell lung cancer by regulating T cell immune function through PD-L1-expressing extracellular vesicles.	No abstract available