Protein detail
CCR4
C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)
Protein symbol CCR4 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 7 | Protein classification CD markersFDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins |
Basic Information
Protein Names
C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)
Protein Class
CD markersFDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins
Protein Function
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
- CD markers
- FDA approved drug targets:Biotech drugs
Transmembrane
40..67; Helical; Name=1; 78..98; Helical; Name=2; 112..133; Helical; Name=3; 151..175; Helical; Name=4; 207..226; Helical; Name=5; 243..267; Helical; Name=6; 285..308; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
CC-CKR-4CD194ChemR13CKR4CMKBR4k5-5
Gene Description
C-C motif chemokine receptor 4
Chromosome
3
Position
32951644-32956349
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAdrenal cortex cells
Function & Pathway
Protein Function
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
- CD markers
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
68 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | Kirouac2010 | No | Yes | No | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | No | Yes | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CCL2 | P13500 | CCR4 | P51679 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKKEGG-MEDICUStalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019WangLRdbCellCallHPMR_talklr | SIGNOR:17160712Baccin2019:16421945LRdb:16421945CellTalkDB:16421945connectomeDB2020:16421945 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 12645951 |
Sequence, Structure & Domains
Sequences
Length
360
Mass
41,403
Sequence
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
3D Structural Models
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Phase 2; Investigative; Phase 1; Approved; Phase 1/2
Drug Targets
FDA approved drug targets
Drugs
Antibody