EV MemProt Atlas

Basic Information

Protein Names

C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)

Protein Function

Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
Human disease related genes:Endocrine and metabolic diseases:Diabetes
CD markers
G-protein coupled receptors:GPCRs excl olfactory receptors
G-protein coupled receptors:Chemokines and chemotactic factors receptors
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

31..58; Helical; Name=1; 69..89; Helical; Name=2; 103..124; Helical; Name=3; 142..166; Helical; Name=4; 199..218; Helical; Name=5; 236..260; Helical; Name=6; 278..301; Helical; Name=7

Transmembrane Count

7

Ensembl

ENSG00000160791

Entrez Gene Symbol

CCR5

EVMP Score

0.38

Fluorescence & Localization

Function & Pathway

Protein Function

Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
Human disease related genes:Endocrine and metabolic diseases:Diabetes
CD markers
G-protein coupled receptors:GPCRs excl olfactory receptors
G-protein coupled receptors:Chemokines and chemotactic factors receptors
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

33 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CCR5	GRK3	P35626	S	336	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:10085131 SIGNOR:10085131 KEA:12403770 ProtMapper:10085131 phosphoELM:10085131 phosphoELM:12403770
CCR5	GRK3	P35626	S	337	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:10085131 KEA:10085131 SIGNOR:10085131 phosphoELM:10085131
CCR5	GRK3	P35626	S	342	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:10085131 KEA:10085131 SIGNOR:10085131 phosphoELM:10085131
CCR5	GRK3	P35626	S	349	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:10085131 KEA:10085131
CCR5	GRK2	P25098	S	336	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPdbPTM	dbPTM:10085131
CCR5	GRK2	P25098	S	337	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPdbPTM	dbPTM:10085131
CCR5	GRK2	P25098	S	342	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPdbPTM	dbPTM:10085131
CCR5	GRK2	P25098	S	349	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
CCR5	GRK4	P32298	S	336	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
CCR5	GRK4	P32298	S	337	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP

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Ligand-Receptor Signaling

61 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	Kirouac2010	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No

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Regulatory Interaction Network

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CCL5	P13501	CCR5	P51681	Yes	Yes	No	iTALKKEGG-MEDICUSGuide2Pharma_LRdbICELLNETProtMapperSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDIntActDLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDCellinkerREACH_ProtMapperSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE	connectomeDB2020:11116158 Cellinker:14637022 DIP:9334377 Guide2Pharma:10318947 HPRD:9289016 Cellinker:11116158 scConnect:10318947 HINT:14637022 Lit-BM-17:23480650 SPIKE:10477718 Guide2Pharma:16298345 HPRD:10477718 connectomeDB2020:8663314 HPRD:14637022 LRdb:10699158 Lit-BM-17:9334377 Guide2Pharma:9790730 IntAct:28381538 connectomeDB2020:10318947 connectomeDB2020:16298345 InnateDB:12213786 connectomeDB2020:9790730 DIP:10477718 Lit-BM-17:11116158 Cellinker:9289016 HINT:23480650 connectomeDB2020:10477718 Cellinker:10477718 SPIKE_LC:10477718 HPRD:8663314 Lit-BM-17:14637022 Cellinker:12964882 Cellinker:8663314 HINT:11116158 Cellinker:10318947 connectomeDB2020:9289016 Lit-BM-17:9207005 connectomeDB2020:12964882 HINT:29619777 HPRD:11116158 HINT:10477718 Lit-BM-17:11449371 Cellinker:9790730 scConnect:16298345 Lit-BM-17:10477718 ProtMapper:25923671 SIGNOR:38339310 connectomeDB2020:14637022 scConnect:9790730 ICELLNET:22633458 DIP:9207005 Lit-BM-17:10488147 DIP:10488147 HINT:9289016 HINT:11449371 Cellinker:16298345 InnateDB:10477718 HINT:34134983 BioGRID:14637022 IntAct:23480650 HINT:8663314
CCL4	P13236	CCR5	P51681	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORHINTInnateDBDIPLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDRamilowski2015_Baccin2019DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE	DIP:9334377 Lit-BM-17:10498628 InnateDB:16467191 CellTalkDB:10699158 Guide2Pharma:16298345 connectomeDB2020:8663314 LRdb:10699158 Lit-BM-17:9334377 Cellinker:12427015 Lit-BM-17:9468473 Guide2Pharma:9790730 HINT:12427015 connectomeDB2020:16298345 SPIKE_LC:12427015 connectomeDB2020:9790730 Lit-BM-17:23597562 DIP:10477718 SPIKE_LC:8663314 Baccin2019:12964882 connectomeDB2020:12427015 HPRD:8663314 Cellinker:12964882 Cellinker:8663314 connectomeDB2020:12964882 DIP:10498628 HINT:10477718 Cellinker:9790730 scConnect:16298345 Lit-BM-17:10477718 scConnect:9790730 ICELLNET:22633458 SIGNOR:20219869 HPRD:12427015 InnateDB:12427015 DIP:9468473 Baccin2019:12427015 Cellinker:16298345 SPIKE:8663314 Baccin2019:8663314 InnateDB:10477718 Baccin2019:16298345 Baccin2019:9790730 SPIKE:12427015 HINT:8663314
CCR5	P51681	JAK3	P52333	Yes	Yes	No	WangSignaLink3TCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:12495636 SignaLink3:11406370 SignaLink3:17169327
CCR5	P51681	GNAI1	P63096	Yes	Yes	No	KEGG-MEDICUSHPRDHINTSignaLink3WangTCRcuration_SignaLink3	SignaLink3:16183910 SignaLink3:10508237 HINT:34230484 SignaLink3:18538863 SignaLink3:23109003 HPRD:15251452 SignaLink3:15337520 SignaLink3:17084806 HINT:34134983 SignaLink3:10644702
CCR5	P51681	GNAI2	P04899	Yes	Yes	No	KEGG-MEDICUSHPRDSignaLink3WangTCRcuration_SignaLink3	SignaLink3:16183910 SignaLink3:10508237 SignaLink3:18538863 SignaLink3:23109003 HPRD:15251452 SignaLink3:15337520 SignaLink3:17084806 SignaLink3:10644702
CCR5	P51681	GNAI3	P08754	Yes	Yes	No	KEGG-MEDICUSHPRDSignaLink3WangTCRcuration_SignaLink3	SignaLink3:16183910 SignaLink3:10508237 SignaLink3:18538863 SignaLink3:23109003 HPRD:15251452 SignaLink3:15337520 SignaLink3:17084806 SignaLink3:10644702
CCL3	P10147	CCR5	P51681	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerInnateDBDIPHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDRamilowski2015_Baccin2019DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	DIP:9334377 Baccin2019:11700073 DIP:9169459 scConnect:11170631 Cellinker:11700073 Guide2Pharma:16298345 HPRD:10477718 Baccin2019:11734558 LRdb:10699158 Guide2Pharma:9790730 connectomeDB2020:16298345 HINT:11700073 connectomeDB2020:9790730 DIP:10477718 Guide2Pharma:11170631 InnateDB:23765404 Baccin2019:12964882 connectomeDB2020:11170631 connectomeDB2020:10477718 Cellinker:10477718 HPMR:12964882 Cellinker:12964882 HPRD:11700073 SIGNOR:15075201 connectomeDB2020:12964882 HINT:10477718 Cellinker:9790730 scConnect:16298345 Baccin2019:10364178 scConnect:9790730 Baccin2019:10477718 Cellinker:11170631 ICELLNET:22633458 connectomeDB2020:11700073 SIGNOR:20219869 Baccin2019:11170631 DIP:9468473 Cellinker:16298345 InnateDB:10477718 Baccin2019:16298345 Baccin2019:9790730
ARBK2	P35626	CCR5	P51681	Yes	Yes	Yes	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite	HPRD:10085131 PhosphoSite:10085131 PhosphoSite:18753410 KEA:10085131 PhosphoSite:11782464 SIGNOR:10085131 KEA:12403770 PhosphoSite:25923671 ProtMapper:10085131 phosphoELM:10085131 PhosphoSite:21148810 phosphoELM:12403770 PhosphoSite:12065593 PhosphoSite:12403770

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CCL5 CCR5	P13501 P51681	1:1	PDB	PDB:5uiwPDB:6fgp
ARRB1 CCR5	P49407 P51681	1:1	PDB	PDB:8as3PDB:8as2
CCR5	P51681	2	PDB	PDB:4mbsPDB:6akx

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryMass spectrometry\|FACSMass spectrometry [LTQ-FT Ultra]\|Western blottingR Sequencing	5	12645951 36359760 36587540 36612172 37115163

Sequence, Structure & Domains

Sequences

Length

352

Mass

40,524

Sequence

MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL

3D Structural Models

Turn

20..22; 58..61; 133..135; 260..265

Helix

10..13; 14..17; 23..57; 64..91; 97..131; 136..139; 142..165; 184..186; 187..202; 204..221; 227..259; 269..288; 289..291; 292..299; 302..313

Beta Strand

167..172; 175..180; 341..344

3D Structure

Electron microscopy (6); NMR spectroscopy (5); X-ray crystallography (10)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Related Diseases

Chronic kidney disease Chronic obstructive pulmonary disease Diabetes mellitus Human immunodeficiency virus disease Postoperative inflammation Rheumatoid arthritis Solid tumour/cancer Transplant rejection COVID-19

Biomarker

Phase 2; Phase 3; Investigative; Approved; Phase 2a; Discontinued in Phase 1; Phase 1; Terminated

Interaction Protein

ENSG00000271503

Interaction Count

1

Interaction Dataset

intact_biogrid

Protein symbol CCR5	UniProt ID P51681	EVMP score 0.38
Frequency	Transmembrane count 7	Protein classification