Protein detail

APLP1

Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30]

Entry name APLP1	UniProt ID P51693	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count 1	Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30]

Protein Class (3)

Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

581..603; Helical

Transmembrane Count

Ensembl

ENSG00000105290

Entrez Gene Symbol

APLP1

Gene Synonym

APLP

Gene Description

Amyloid beta precursor like protein 1

Chromosome

Position

35867899-35879792

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (5)

Molecular Function (7)

Biological Process (3)

Canonical Pathways

M50 Pid ptp1b pathway

Mediation Categories

Receptor-signaling mediation

Relations & Evidence38

Ligand-Receptor Signaling (34)

34 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	LOCATE	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No

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Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
APLP1	P51693	2	PDB	PDB:3pmrPDB:3q7lPDB:4rdaPDB:4rd9PDB:3qmkPDB:3q7g
APBB2 APLP1 ATP7A SYDE2	P51693 Q04656 Q5VT97 Q92870	0:0:0:0	hu.MAP
APBB2 APLP1 OSBPL2 SYDE2	P51693 Q5VT97 Q92870 Q9H1P3	0:0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometryR Sequencing	1	32384937

Sequence, Structure & Domains16

Sequences

Length

650

Mass

72,176

Sequence

MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51693-1; Sequence=Displayed; Name=2; IsoId=P51693-2; Sequence=VSP_039100

Alternative Sequence

517; D -> DA (in isoform 2)

3D Structural Models

Turn

338..341; 443..445

Helix

293..298; 306..337; 344..399; 406..437; 439..442; 446..467; 471..485

Beta Strand

302..304; 401..403

3D Structure

X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

504..519; Basic and acidic residues; 534..546; Basic and acidic residues

Motif

604..615; Basolateral sorting signal; 640..643; Clathrin-binding; 640..643; NPXY motif; contains endocytosis signal

Domain (CC)

The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis.

Domain (FT)

50..212; E1; 293..484; E2

Region

50..146; GFLD subdomain; 154..212; CuBD subdomain; 214..287; Disordered; 285..305; O-glycosylated at three sites; 310..342; Heparin-binding; 410..441; Heparin-binding; 442..459; Collagen-binding; 492..546; Disordered; 632..649; Interaction with DAB1; 636..650; Interaction with DAB2

Protein Families

APP family

Sequence Similarities

Belongs to the APP family.

Clinical Relevance6

Disease Involvement

Neurodegeneration

Drugs (9)

LV-2172 QRFP26 (26RFA)QRFP43 (43RFA)QRFP43 [125I]QRFP43 (HUMAN)COMPOUND 25E [PMID: 25875054][125I]26RFA (HUMAN)LV-2211 LV-2186

Antibody (2)

HPA028970 HPA028971

Interaction Protein (3)

ENSG00000102804ENSG00000167900ENSG00000172466

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
37867176	Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease.	No abstract available