Protein detail
CLCN5
H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)
Protein symbol CLCN5 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 10 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Urinary system diseases:Kidney diseases
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Transmembrane
125..162; Helical; 208..231; Helical; 256..275; Helical; 281..300; Helical; 348..366; Helical; 389..415; Helical; 422..442; Helical; 498..518; Helical; 523..542; Helical; 605..622; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
ClC-5CLC5DENTShCIC-K2hClC-K2NPHL1NPHL2XLRHXRN
Gene Description
Chloride voltage-gated channel 5
Chromosome
X
Position
49922596-50099235
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificCone photoreceptor cellsBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Human disease related genes:Urinary system diseases:Kidney diseases
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| ion_channel | ion_channel | Almen2009 | No | Yes | No | No | No |
| voltage_gated_chloride | ion_channel | Almen2009 | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NED4L | Q96PU5 | CLCN5 | P51795 | Yes | No | Yes | SIGNOR | SIGNOR:15489223 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster393 | CLCN3CLCN4CLCN5TMEM9TMEM9B | P51790P51793P51795Q9NQ34Q9P0T7 | 1:1:1:1:1 | Compleat | Compleat:HC2802 | 22036573 |
| CLCN5RUFY1RUFY2SERPINB7 | O75635P51795Q8WXA3Q96T51 | 0:0:0:0 | hu.MAP2 | |||
| ADGRG5CLCN3CLCN5TMEM9B | P51790P51795Q8IZF4Q9NQ34 | 0:0:0:0 | hu.MAP2 | |||
| CLCN5 | P51795 | 6 | PDB | PDB:2j9lPDB:2ja3 | ||
| CLCN5TMEM9B | P51795Q9NQ34 | 0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 27605433 |
Sequence, Structure & Domains
Sequences
Length
816
Mass
90,785
Sequence
MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYNGGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51795-2; Sequence=Displayed; Name=2; IsoId=P51795-1; Sequence=VSP_060654
Alternative Sequence
1..70; Missing (in isoform 2)
3D Structural Models
Turn
696..698
Helix
652..655; 675..684; 707..718; 750..752; 766..776; 795..805
Beta Strand
656..658; 668..671; 688..694; 700..706; 729..731; 733..735; 753..756; 759..761; 779..785; 788..794
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
12..25; Low complexity
Motif
237..241; Selectivity filter part_1; 279..283; Selectivity filter part_2; 523..527; Selectivity filter part_3
Domain (FT)
656..720; CBS 1; 752..812; CBS 2
Region
1..26; Disordered
Protein Families
- Chloride channel (TC 2.A.49) family
- ClC-5/CLCN5 subfamily
Sequence Similarities
Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.