Protein detail

CLCN5

H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)

Entry name
CLCN5
UniProt ID
P51795
EVMP confidence score
0.53
Supporting publications (n)
3
Transmembrane count
10
Protein classification
Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Basic Information
Protein Names
H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)
Protein Class (7)
Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (6)
  • Human disease related genes:Urinary system diseases:Kidney diseases
  • Predicted intracellular proteins
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
  • Potential drug targets
  • Transporters:Electrochemical Potential-driven transporters
  • Disease related genes
Transmembrane
125..162; Helical; 208..231; Helical; 256..275; Helical; 281..300; Helical; 348..366; Helical; 389..415; Helical; 422..442; Helical; 498..518; Helical; 523..542; Helical; 605..622; Helical
Transmembrane Count
10
Ensembl
ENSG00000171365
Entrez Gene Symbol
CLCN5
Gene Synonym (9)
ClC-5CLC5DENTShCIC-K2hClC-K2NPHL1NPHL2XLRHXRN
Gene Description
Chloride voltage-gated channel 5
Chromosome
X
Position
49922596-50099235
Supporting publications (n)
3
EVMP confidence score
0.53
Fluorescence & Localization
CLCN5 fluorescence
Tissue Specificheart muscleCell SpecificCone photoreceptor cellsBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function (6)
  • Human disease related genes:Urinary system diseases:Kidney diseases
  • Predicted intracellular proteins
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
  • Potential drug targets
  • Transporters:Electrochemical Potential-driven transporters
  • Disease related genes
Cellular Component (10)
Molecular Function (5)
Biological Process (3)
KEGG
hsa04613 Neutrophil extracellular trap formation
Reactome (3)
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence31

Ligand-Receptor Signaling (24)

24 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathYes
intracellularintracellularLOCATE
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
ion_channelion_channelDGIdbYes
ion_channelion_channelAlmen2009Yes
voltage_gated_chlorideion_channelAlmen2009Yes
transportertransporterOmniPathYes
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Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
NED4LQ96PU5CLCN5P51795YesYesSIGNORSIGNOR:15489223

Protein Complex Composition (5)

5 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
HT_DM_Cluster393CLCN3CLCN4CLCN5TMEM9TMEM9BP51790P51793P51795Q9NQ34Q9P0T71:1:1:1:1CompleatCompleat:HC280222036573
CLCN5RUFY1RUFY2SERPINB7O75635P51795Q8WXA3Q96T510:0:0:0hu.MAP2
ADGRG5CLCN3CLCN5TMEM9BP51790P51795Q8IZF4Q9NQ340:0:0:0hu.MAP2
CLCN5P517956PDBPDB:2j9lPDB:2ja3
CLCN5TMEM9BP51795Q9NQ340:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry127605433
Sequence, Structure & Domains

Sequences

Length
816
Mass
90,785
Sequence
MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYNGGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51795-2; Sequence=Displayed; Name=2; IsoId=P51795-1; Sequence=VSP_060654
Alternative Sequence
1..70; Missing (in isoform 2)

3D Structural Models

Turn
696..698
Helix
652..655; 675..684; 707..718; 750..752; 766..776; 795..805
Beta Strand
656..658; 668..671; 688..694; 700..706; 729..731; 733..735; 753..756; 759..761; 779..785; 788..794
3D Structure
X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias
12..25; Low complexity
Motif
237..241; Selectivity filter part_1; 279..283; Selectivity filter part_2; 523..527; Selectivity filter part_3
Domain (FT)
656..720; CBS 1; 752..812; CBS 2
Region
1..26; Disordered
Protein Families (2)
  • Chloride channel (TC 2.A.49) family
  • ClC-5/CLCN5 subfamily
Sequence Similarities
Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
Clinical Relevance
Disease Involvement
Disease variant
Drug Targets (2)
Literature-reported targetSuccessful target
Antibody (2)
HPA000401HPA003213
Interaction Protein (2)
ENSG00000116857ENSG00000175348
Interaction Count
2
Interaction Dataset
biogrid_bioplex
Supporting Publications3
PMIDTitleRelated sentences
37322475Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.No related sentences available
38113368In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.No related sentences available
38207106Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.No related sentences available