Protein detail

CLCN5

H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)

Entry name CLCN5	UniProt ID P51795	EVMP confidence score 0.50
Supporting publications (n) 3	Transmembrane count 10	Protein classification Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)

Protein Class (7)

Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (6)

Human disease related genes:Urinary system diseases:Kidney diseases
Predicted intracellular proteins
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Disease related genes

Transmembrane

125..162; Helical; 208..231; Helical; 256..275; Helical; 281..300; Helical; 348..366; Helical; 389..415; Helical; 422..442; Helical; 498..518; Helical; 523..542; Helical; 605..622; Helical

Transmembrane Count

Ensembl

ENSG00000171365

Entrez Gene Symbol

CLCN5

Gene Synonym (9)

ClC-5CLC5DENTShCIC-K2hClC-K2NPHL1NPHL2XLRHXRN

Gene Description

Chloride voltage-gated channel 5

Chromosome

Position

49922596-50099235

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue Specificheart muscleCell SpecificCone photoreceptor cellsBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells

Function & Pathway7

Protein Function (6)

Human disease related genes:Urinary system diseases:Kidney diseases
Predicted intracellular proteins
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Disease related genes

Cellular Component (10)

Molecular Function (5)

Biological Process (3)

KEGG

hsa04613 Neutrophil extracellular trap formation

Reactome (3)

Mediation Categories (2)

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence31

Ligand-Receptor Signaling (24)

24 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NED4L	Q96PU5	CLCN5	P51795	Yes	No	Yes	SIGNOR	SIGNOR:15489223

Protein Complex Composition (5)

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster393	CLCN3 CLCN4 CLCN5 TMEM9 TMEM9B	P51790 P51793 P51795 Q9NQ34 Q9P0T7	1:1:1:1:1	Compleat	Compleat:HC2802	22036573
	CLCN5 RUFY1 RUFY2 SERPINB7	O75635 P51795 Q8WXA3 Q96T51	0:0:0:0	hu.MAP2
	ADGRG5 CLCN3 CLCN5 TMEM9B	P51790 P51795 Q8IZF4 Q9NQ34	0:0:0:0	hu.MAP2
	CLCN5	P51795	6	PDB	PDB:2j9lPDB:2ja3
	CLCN5 TMEM9B	P51795 Q9NQ34	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27605433

Sequence, Structure & Domains15

Sequences

Length

816

Mass

90,785

Sequence

MAMWQGAMDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGEDKSYNGGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51795-2; Sequence=Displayed; Name=2; IsoId=P51795-1; Sequence=VSP_060654

Alternative Sequence

1..70; Missing (in isoform 2)

3D Structural Models

Turn

696..698

Helix

652..655; 675..684; 707..718; 750..752; 766..776; 795..805

Beta Strand

656..658; 668..671; 688..694; 700..706; 729..731; 733..735; 753..756; 759..761; 779..785; 788..794

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

12..25; Low complexity

Motif

237..241; Selectivity filter part_1; 279..283; Selectivity filter part_2; 523..527; Selectivity filter part_3

Domain (FT)

656..720; CBS 1; 752..812; CBS 2

Region

1..26; Disordered

Protein Families (2)

Chloride channel (TC 2.A.49) family
ClC-5/CLCN5 subfamily

Sequence Similarities

Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.

Clinical Relevance6

Disease Involvement

Disease variant

Drug Targets (2)

Literature-reported targetSuccessful target

Antibody (2)

HPA000401 HPA003213

Interaction Protein (2)

ENSG00000116857ENSG00000175348

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications3

PMID	Title	Abstract
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available