Protein detail
CLCN6
H(+)/Cl(-) exchange transporter 6 (Chloride channel protein 6) (ClC-6) (Chloride transport protein 6)
Protein symbol CLCN6 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 10 | Protein classification Disease related genesPlasma proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
H(+)/Cl(-) exchange transporter 6 (Chloride channel protein 6) (ClC-6) (Chloride transport protein 6)
Protein Class
Disease related genesPlasma proteinsPredicted membrane proteins
Protein Function
Disease related genes
Transmembrane
81..113; Helical; 128..150; Helical; 176..194; Helical; 200..217; Helical; 277..294; Helical; 335..364; Helical; 371..392; Helical; 462..481; Helical; 487..511; Helical; 553..571; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
CLC-6KIAA0046
Gene Description
Chloride voltage-gated channel 6
Chromosome
1
Position
11806096-11848079
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificthyroid glandCell SpecificColonocytesSingle-Nuclei Brain Specificlower rhombic lipBlood Cell Specificneutrophil
Function & Pathway
Protein Function
Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| peripheral | peripheral | UniProt_topology | No | No | No | No | No |
| peripheral | peripheral | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometryWestern blotting | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
869
Mass
97,289
Sequence
MAGCRGSLCCCCRWCCCCGERETRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVEKEGPMIHSGSVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRSQSMKSYPSSELRNMCDEHIASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTYEFLQARLRQHYQTI
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=A, Clc-6a; IsoId=P51797-1; Sequence=Displayed; Name=2; Synonyms=B, ClC-6b, D2-A1; IsoId=P51797-2; Sequence=VSP_001043, VSP_001044; Name=3; Synonyms=C, ClC-6c, D1-A1; IsoId=P51797-3; Sequence=VSP_001045, VSP_001046; Name=4; Synonyms=D, ClC-6d, D1-A2; IsoId=P51797-4; Sequence=VSP_001047, VSP_001048; Name=5; IsoId=P51797-5; Sequence=VSP_017188; Name=6; IsoId=P51797-6; Sequence=VSP_047169
Alternative Sequence
50..71; Missing (in isoform 6); 237..320; DKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCS -> YGKRQERLCISRSGCWSCCSFRGANRGYLVQSRGGFVLLEPRAHVESALLFHVCHLHPQLLPFWDSVWKLGFLPAPWIAELWRV (in isoform 2); 237..308; DKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQL -> SGCWSCCSFRGANRGYLVQSRGGFVLLEPRAHVESALLFHVCHLHPQLLPFWDSVWKLGFLPAPWIAELWRV (in isoform 4); 309..869; Missing (in isoform 4); 319..353; CSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNC -> SLREPPCVSGNHRGGVCGLDGVRRMPTDVLFESNR (in isoform 3); 321..869; Missing (in isoform 2); 354..869; Missing (in isoform 3); 844..869; IVGIITRHNLTYEFLQARLRQHYQTI -> VSEAPALPPPLREDPLARCCLCTQASHQKRRHPTRRGECGPTLALNPARLPCTRDPFPCLPADGTSVPLAVLSSQSRASTRLCLPPEMLLFTPYHWCSLVLHLRRDLRIR (in isoform 5)
3D Structural Models
Turn
166..168; 274..276; 371..375; 569..571; 582..584; 787..789; 804..806
Helix
59..67; 70..122; 128..150; 152..154; 159..161; 162..165; 177..190; 191..193; 202..213; 230..232; 235..254; 257..265; 277..298; 333..365; 376..394; 437..442; 446..455; 462..479; 489..510; 519..533; 539..548; 551..553; 554..568; 575..581; 594..597; 601..604; 618..627; 650..663; 667..676; 732..735; 747..755; 774..778; 820..829; 850..852; 855..868
Beta Strand
174..176; 199..201; 266..268; 299..301; 367..369; 399..401; 434..436; 457..460; 482..484; 614..617; 631..638; 739..746; 762..764; 793..795; 807..810; 833..838; 842..848
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Motif
156..160; Selectivity filter part_1; 198..202; Selectivity filter part_2; 487..491; Selectivity filter part_3
Domain (FT)
605..662; CBS 1; 807..868; CBS 2
Protein Families
- Chloride channel (TC 2.A.49) family
- ClC-6/CLCN6 subfamily
Sequence Similarities
Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily.
Clinical Relevance
Disease Involvement
Disease variantNeurodegenerationNeuronal ceroid lipofuscinosis
Antibody