Protein detail

PLXA3

Plexin-A3 (Plexin-4) (Semaphorin receptor SEX)

Entry name PLXA3	UniProt ID P51805	EVMP score 0.38
Frequency 2	Transmembrane count 1	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Plexin-A3 (Plexin-4) (Semaphorin receptor SEX)

Transmembrane

1221..1241; Helical

Transmembrane Count

Ensembl

ENSG00000130827

Entrez Gene Symbol

PLXNA3

Frequency

EVMP Score

0.38

Fluorescence & Localization

Function & Pathway

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M86 Pid arf6 pathway

Mediation Categories

Adhesion and uptake mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

52 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plexin	receptor	Almen2009	No	Yes	No	Yes	No
plexins	receptor	HPMR	No	Yes	No	Yes	No
plexin	receptor	Surfaceome	No	Yes	No	Yes	No
semaphorin	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PLXNA3-RANBPM complex	PLXNA3 RANBP9	P51805 Q96S59	1:1	CompleatCORUM	Compleat:HC1031CORUM:5759	16672672
	FAM234B GALNT13 MBTPS1 PLXNA3 PTPRU	A2RU67 P51805 Q14703 Q8IUC8 Q92729	0:0:0:0:0	hu.MAP
	CHST10 CNTNAP3 ENTPD6 GALNT13 LRIG1 PLXNA3 PTPRU	O43529 O75354 P51805 Q8IUC8 Q92729 Q96JA1 Q9BZ76	0:0:0:0:0:0:0	hu.MAP
	KNTC1 MLH1 PLXNA3 PMS1 PMS2	P40692 P50748 P51805 P54277 P54278	0:0:0:0:0	hu.MAP2
	GALNT13 LRIG1 PLXNA3	P51805 Q8IUC8 Q96JA1	0:0:0	hu.MAP

Isolation & Detection Technology

0 records.

Sequence, Structure & Domains

Sequences

Length

1,871

Mass

207,717

Sequence

MPSVCLLLLLFLAVGGALGNRPFRAFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPVEDNARCYPPPSMRVCAHRLAPVDNINKLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGQGPSKLFVGTAVDGKSEYFPTLSSRKLISDEDSADMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRASPPRQTILCLFTLSNINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYQSCAACLGSGDPHCGWCVLRHRCCREGACLGASAPHGFAEELSKCVQVRVRPNNVSVTSPGVQLTVTLHNVPDLSAGVSCAFEAAAENEAVLLPSGELLCPSPSLQELRALTRGHGATRTVRLQLLSKETGVRFAGADFVFYNCSVLQSCMSCVGSPYPCHWCKYRHTCTSRPHECSFQEGRVHSPEGCPEILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQQRVPAVRFNSSSVQCQNASYSYEGDEHGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRTHCPAPKTNWMHLSQKGTRCSHPRITQIHPLVGPKEGGTRVTIVGENLGLLSREVGLRVAGVRCNSIPAEYISAERIVCEMEESLVPSPPPGPVELCVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTRLTISGSSLDAGSRVTVTVRDSECQFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLIYTYTQDPTVTRLEPTWSIINGSTAITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLCKAPGIFLGRPQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCSLTVSDTQLLCDSPSQTGRQPVMVLVGGLEFWLGTLHISAERALTLPAMMGLAAGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQMDNLESRVALECKEAFAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTPPNVEKALRLFGQLLHSRAFVLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPENEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMTRIILQDEDVTTKIECDWKRLNSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRTASSPDSLRSRAPMITPDQETGTKLWHLVKNHDHADHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHASDFSVLSALNELYFYVTKYRQEILTALDRDASCRKHKLRQKLEQIISLVSSDS

3D Structural Models

Domain & Motif Annotations

Domain (FT)

20..488; Sema; 840..933; IPT/TIG 1; 935..1020; IPT/TIG 2; 1023..1122; IPT/TIG 3; 1125..1211; IPT/TIG 4

Protein Families

Plexin family

Sequence Similarities

Belongs to the plexin family.

Clinical Relevance